Traumatic Axonal Injury in Patients with Mild Traumatic Brain Injury

Mild traumatic brain injury (TBI) is a subtype of TBI that is classified by the severity of head trauma, whereas traumatic axonal injury (TAI) is a diagnostic term with a pathological meaning. In this chapter, TAI in patients with mild TBI is described in terms of definition, history, and diagnostic approach. The presence of TAI in patients with mild TBI has been demonstrated by autopsy studies since the 1960s. However, because conventional brain CT or MRI are not powered with contrast resolution to determine TAI in mild TBI, diagnosis of TAI in live patients with mild TBI was impossible. Since the introduction of diffusion tensor imaging, hundreds of studies have demonstrated TAI in live patients with mild TBI in the 2000s. The precise diagnosis of TAI in patients with mild TBI is clinically important for proper management and prognosis prediction following mild TBI. Several requirements are necessary for diagnosis of TAI in mild TBI: first, head trauma history; second, development of new clinical symptoms and signs after head trauma; third, evidence of TAI of the neural tracts on diffusion tensor imaging or diffusion tensor tractography; and fourth, coincidence of the newly developed clinical features and the function of injured neural tracts

Detection of Intracluster Globular Clusters in the First JWST Images of the Gravitational Lens Cluster SMACS J0723.3-7327 at z = 0.39

We present a survey of globular clusters (GCs) in the massive gravitational lens cluster SMACS J0723.3-7327 at $z=0.39$ based on the early released JWST/NIRCam images. In the color-magnitude diagrams of the point sources we find clearly a rich population of intracluster GCs that spread in a wide area of the cluster. Their ages, considering the cluster redshift, are younger than 9.5 Gyr. The F200W (AB) magnitudes of these GCs, $26.5<{F200W_0} <29.5$ mag, correspond to $-15.2<{M_{F200W}} <-12.2$ mag, showing that they belong to the brightest GCs (including ultracompact dwarfs). The spatial distributions of these GCs show a megaparsec-scale structure elongated along the major axis of the brightest cluster galaxy. In addition, they show a large number of substructures, some of which are consistent with the substructures seen in the map of diffuse intracluster light. The GC number density map is, in general, consistent with the dark matter mass density map based on the strong lensing analysis in the literature. The radial number density profile of the GCs in the outer region is steeper than the dark matter mass profile obtained from lensing models. These results are consistent with those for the GCs found in the deep HST images of Abell 2744, another massive cluster at $z=0.308$, and in simulated galaxy clusters. This shows that the intracluster GCs are an excellent independent tool to probe the dark matter distribution in galaxy clusters as well as to reveal the cluster assembly history in the JWST era.Comment: 25 pages, 12 figures, Accepted for publication in ApJ

Gene Expression Profiles are Altered in Human Papillomavirus-16 E6 D25E-Expressing Cell Lines

Previously, we have reported that the human papillomavirus (HPV) type 16 E6 D25E is the most prevalent variant in Korean women at high risk for cervical cancers. Several studies have identified an association between the increased frequency of this variant and the elevated risk of cervical intraepithelial neoplasia and invasive cervical carcinoma. To investigate whether the HPV-16 E6 D25E variant might influence cervical cancer progression, we used an oligonucleotide microarray approach to identify transcriptionally altered gene expression patterns in recombinant wild-type E6 or E6 D25E variant-expressing HPV-negative cancer cells. We found that 211 genes were significantly up- or down-regulated (at least 1.5-fold, p < 0.05). We identified 14 genes, nine down-regulated and five up-regulated upon E6 D25E expression, compared with wild-type E6 expression. These results further emphasize the unique biological activity of the HPV-16 E6 D25E variant

Diffusion Tensor Tractography Studies on Injured Anterior Cingulum Recovery Mechanisms: A Mini-Review

The cingulum, a major structure in the limbic system, contains the medial cholinergic pathway, which originates from the basalis nucleus of Meynert (Ch 4) in the basal forebrain. The cingulum is involved in various cognitive functions, including memory, attention, learning, motivation, emotion, and pain perception. In this mini-review, 10 studies reporting on recovery mechanisms of injured cinguli in patients with brain injury were reviewed. The recovery mechanisms of the injured anterior cinguli reported in those 10 studies are classified as follows: Mechanism 1, recovery via the normal pathway of the cingulum between the injured cingulum and Ch 4; mechanism 2, recovery through the neural tract between the injured cingulum and the brainstem cholinergic nuclei; mechanism 3, recovery via the lateral cholinergic pathway between the injured cingulum and the white matter of the temporo-occipital lobes; mechanism 4, recovery through the neural tract between the contralesional basal forebrain and the ipsilesional basal forebrain via the genu of the corpus callosum; and mechanism 5, recovery through the neural tract between the injured cingulum and Ch 4 via an aberrant pathway. Elucidation of the recovery mechanisms of injured anterior cinguli might be useful for neurorehabilitation of patients with anterior cingulum injuries. Diffusion tensor tractography appears to be useful in the detection of recovery mechanisms of injured anterior cinguli in patients with brain injury. However, studies on cingulum injury recovery mechanisms are still in the early stages because most of the above studies are case reports confined to a few brain pathologies. Therefore, further studies involving large numbers of subjects with various brain pathologies should be encouraged. In addition, studies on the influencing factors and clinical outcomes associated with each recovery mechanism are warranted

Radar-based nowcasting by combining centroid tracking and motion vector of convective storm

Póster presentado en: 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019

Origin of Difference in the Reactivity of Aliphatic and Aromatic Guanidine-containing Pharmaceuticals Toward [18F]Fluorination: Coulombic Forces and Hydrogen Bonding

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151351/1/bkcs11842.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151351/2/bkcs11842_am.pd

Characteristics of injury of the corticospinal tract and corticoreticular pathway in hemiparetic patients with putaminal hemorrhage

BACKGROUND: No study on the characteristics of injury of the corticospinal tract (CST) or corticoreticular pathway (CRP) in patients with putaminal hemorrhage has been reported. In this study, using diffusion tensor tractography, we attempted to investigate the characteristics of injury of the CST and CRP in hemiparetic patients with putaminal hemorrhage. METHOD: Fifty seven consecutive patients with putaminal hemorrhage and 57 healthy control subjects were recruited for this study. Diffusion tensor imaging was performed during the early period (8 ~ 30 days) after onset. We defined injury of the CST or CRP in terms of the configuration (discontinuation of a neural tract) or abnormal DTT parameters (the fractional anisotrophy value or fiber number was more than two standard deviations lower than that of normal control subjects). The Motricity Index, the modified Brunnstrom Classification, and the Functional Ambulation Categories were used for evaluation of motor function. RESULTS: Among 57 patients, injury of the CST was found in 41 patients (71.9%) and injury of the CRP was found in 50 patients (87.8%), respectively, and 37 patients (64.9%) had injury of both the CST and CRP. All three motor functions of patients with injury of both the CST and CRP were significantly lower than those of patients with injury of either the CST or CRP (p < 0.05). CONCLUSION: Our results indicate that the putaminal hemorrhage frequently accompanies injury of both the CST and CRP, and the CRP appears to be more vulnerable to putaminal hemorrhage than the CST. These findings suggest the necessity for evaluation of both the CRP and the CST in patients with putaminal hemorrhage

To the Edge of M87 and Beyond: Spectroscopy of Intracluster Globular Clusters and Ultra Compact Dwarfs in the Virgo Cluster

We present the results from a wide-field spectroscopic survey of globular clusters (GCs) in the Virgo Cluster. We obtain spectra for 201 GCs and 55 ultracompact dwarfs (UCDs) using the Hectospec on the Multiple Mirror Telescope, and derive their radial velocities. We identify 46 genuine intracluster GCs (IGCs), not associated with any Virgo galaxies, using the 3D GMM test on the spatial and radial velocity distribution.They are located at the projected distance 200 kpc $\lesssim$ R $\lesssim$ 500 kpc from the center of M87. The radial velocity distribution of these IGCs shows two peaks, one at $v_{\rm r}$ = 1023 km s$^{-1}$ associated with the Virgo main body, and another at $v_{\rm r}$ = 36 km s$^{-1}$ associated with the infalling structure. The velocity dispersion of the IGCs in the Virgo main body is $\sigma_{\rm{GC}} \sim$ 314 km s$^{-1}$, which is smoothly connected to the velocity dispersion profile of M87 GCs, but much lower than that of dwarf galaxies in the same survey field, $\sigma_{\rm{dwarf}} \sim$ 608 km s$^{-1}$. The UCDs are more centrally concentrated on massive galaxies, M87, M86, and M84. The radial velocity dispersion of the UCD system is much smaller than that of dwarf galaxies. Our results confirm the large-scale distribution of Virgo IGCs indicated by previous photometric surveys. The color distribution of the confirmed IGCs shows a bimodality similar to that of M87 GCs. This indicates that most IGCs are stripped off from dwarf galaxies and some from massive galaxies in the Virgo.Comment: 19 pages, 20 figures, 8 tables, accepted for publication in Ap