Impact of Design Interventions in Nursing Home on Residents with Dementia, Their Families, and the Staff

The purpose of this study was to determine whether certain design interventions in a nursing home affected resident with dementia outcomes, family involvement and interaction, and staff perceptions of care delivery. The study was conducted in a nursing home. The study site included dining and bathing facilities that serve smaller groups of residents. The new design promised to contrast the medical orientation of the existing nursing home with a more residential environment. The study design involved a two-group pretest-posttest comparison in which a sample of residents who eventually were relocated to the newly designed wing of the facility (Treatment Group) was compared with a sample that remained in the existing setting (Control Group). Findings and implication of this study provide new knowledge integrating the diverse professional aspects that contribute to a responsive long-term care setting.https://dc.uwm.edu/caupr_mono/1011/thumbnail.jp

Progress of the PRINCIPLE project: promoting MT for Croatian, Icelandic, Irish and Norwegian

This paper updates the progress made on the PRINCIPLE project, a 2-year action funded by the European Commission un-der the Connecting Europe Facility (CEF) programme. PRINCIPLE focuses on col-lecting high-quality language resources for Croatian, Icelandic, Irish and Norwe-gian, which have been identified as low-resource languages, especially for build-ing effective machine translation (MT) systems. We report initial achievements of the project and ongoing activities aimed at promoting the uptake of neural MT for the low-resource languages of the project

Introducing the Digital Language Equality Metric: Technological Factors

This paper introduces the concept of Digital Language Equality (DLE) developed by the EU-funded European Language Equality (ELE) project, and describes the associated DLE Metric with a focus on its technological factors (TFs), which are complemented by situational contextual factors. This work aims at objectively describing the level of technological support of all European languages and lays the foundation to implement a large-scale EU-wide programme to ensure that these languages can continue to exist and prosper in the digital age, to serve the present and future needs of their speakers. The paper situates this ongoing work with a strong European focus in the broader context of related efforts, and explains how the DLE Metric can help track the progress towards DLE for all languages of Europe, focusing in particular on the role played by the TFs. These are derived from the European Language Grid (ELG) Catalogue, that provides the empirical basis to measure the level of digital readiness of all European languages. The DLE Metric scores can be consulted through an online interactive dashboard to show the level of technological support of each European language and track the overall progress toward DLE

Development of a High Throughput (HT) Raman Spectroscopy Method for Rapid Screening of Liquid Blood Plasma From Prostate Cancer Patients

Extensive research has been undertaken on the examination of tissue biopsies using vibrational spectroscopic techniques. However, fewer studies have focused on less invasive and commonly acquired blood samples. Recent studies have shown the ability of Raman and Fourier transform infrared (FTIR) spectroscopy to discriminate between non-cancer controls and cancer cases using blood serum or plasma. Even though many studies have proposed Raman spectroscopy as a potential diagnostic tool in various cancers, the Raman spectroscopic technique has not been introduced as a routine clinical technology. This is due to multiple drawbacks with the application of the technique, including sample preparation, the requirement for expensive substrates and long acquisition times. The current study aims to overcome these limitations and focuses on the translation of Raman spectroscopy into a high throughput clinical diagnostic tool for prostate cancer. In this study, the effect of different instrumental and sample preparation parameters were investigated, with the aim of identifying a combination that would reduce the overall acquisition time for spectra from peripheral blood plasma, reduce the complexity of sample preparation and retain the classification accuracy from Raman spectroscopic diagnostics. A high throughput (HT) system was developed and Raman spectroscopic measurements were performed on plasma samples from 10 prostate cancer patients and 10 healthy volunteers. The spectra were pre-processed and classified by principal component analysis – linear discriminant analysis (PCA-LDA) in the R environment. Statistically significant differences were observed between Raman spectra of prostate cancer patients and non-cancer controls. The (HT) classification resulted in a sensitivity and specificity of 96.5% and 95% respectively. Overall, this study has overcome some of the limitations associated with clinical translation of Raman spectroscopy. The HT-Raman spectroscopy method developed in this study can be used for rapid and accurate diagnosis of prostate cancer using liquid plasma samples

Development of a High Throughput (HT) Raman Spectroscopy Method for Rapid Screening of Liquid Blood Plasma From Prostate Cancer Patients

Extensive research has been undertaken on the examination of tissue biopsies using vibrational spectroscopic techniques. However, fewer studies have focused on less invasive and commonly acquired blood samples. Recent studies have shown the ability of Raman and Fourier transform infrared (FTIR) spectroscopy to discriminate between non-cancer controls and cancer cases using blood serum or plasma. Even though many studies have proposed Raman spectroscopy as a potential diagnostic tool in various cancers, the Raman spectroscopic technique has not been introduced as a routine clinical technology. This is due to multiple drawbacks with the application of the technique, including sample preparation, the requirement for expensive substrates and long acquisition times. The current study aims to overcome these limitations and focuses on the translation of Raman spectroscopy into a high throughput clinical diagnostic tool for prostate cancer. In this study, the effect of different instrumental and sample preparation parameters were investigated, with the aim of identifying a combination that would reduce the overall acquisition time for spectra from peripheral blood plasma, reduce the complexity of sample preparation and retain the classification accuracy from Raman spectroscopic diagnostics. A high throughput (HT) system was developed and Raman spectroscopic measurements were performed on plasma samples from 10 prostate cancer patients and 10 healthy volunteers. The spectra were pre-processed and classified by principal component analysis – linear discriminant analysis (PCA-LDA) in the R environment. Statistically significant differences were observed between Raman spectra of prostate cancer patients and non-cancer controls. The (HT) classification resulted in a sensitivity and specificity of 96.5% and 95% respectively. Overall, this study has overcome some of the limitations associated with clinical translation of Raman spectroscopy. The HT-Raman spectroscopy method developed in this study can be used for rapid and accurate diagnosis of prostate cancer using liquid plasma samples

Measuring violence against children:A COSMIN systematic review of the psychometric properties of child and adolescent self-report measures

Research on violence against children (VAC) requires meaningful, valid, and reliable self-report by children. Many instruments have been used globally and decisions to select suitable measures are complex. This review identifies child and adolescent self-report measures that are most likely to yield valid, reliable, and comparable data in this field. A systematic review (PROSPERO: CRD4201706) was conducted using the 2018 Consensus-based Standards for the selection of health Measurement Instrument (COSMIN) criteria. Six electronic databases and gray literature were searched. Manuscripts published in English and describing the development and psychometric qualities of child/adolescent self-report instruments were included. Thirty-nine original instruments and 13 adaptations were identified in 124 studies. The quality of evidence ranged from “very low” to “high” depending on the measure and the psychometric properties assessed. Most measures were not widely used, and some have been applied in many settings despite limited evidence of their psychometric rigor. Few studies assessed content validity, particularly with children. The ACE, CTQ, CTS-PC, CECA, ICAST, and JVQ have the best psychometric properties. An overview of items measuring frequency, onset, duration, perpetrators, and locations is provided as well as an assessment of the practicalities for administration to help researchers select the instrument best suited for their research questions. This comprehensive review shows the strengths and weaknesses of VAC research instruments. Six measures that have sufficient psychometric properties are recommended for use in research, with the caveat that extensive piloting is carried out to ensure sufficient content validity for the local context and population.</p

Introducing the digital language equality metric: technological factors

This paper introduces the concept of Digital Language Equality (DLE) developed by the EU-funded European Language Equality (ELE) project, and describes the associated DLE Metric with a focus on its technological factors (TFs), which are complemented by situational contextual factors. This work aims at objectively describing the level of technological support of all European languages and lays the foundation to implement a large-scale EU-wide programme to ensure that these languages can continue to exist and prosper in the digital age, to serve the present and future needs of their speakers. The paper situates this ongoing work with a strong European focus in the broader context of related efforts, and explains how the DLE Metric can help track the progress towards DLE for all languages of Europe, focusing in particular on the role played by the TFs. These are derived from the European Language Grid (ELG) Catalogue, that provides the empirical basis to measure the level of digital readiness of all European languages. The DLE Metric scores can be consulted through an online interactive dashboard to show the level of technological support of each European language and track the overall progress toward DLE

Raman Spectroscopy of Lymphocytes for the Identification of Prostate Cancer Patients with Late Radiation Toxicity Following Radiotherapy

The success of radiotherapy in tumour control depends on the total dose given. However, the tolerance of the normal tissues surrounding the tumour limits this dose. It is not known why some patients develop radiation toxicity and, currently, it is not possible to predict before treatment which patients will experience adverse effects. Thus, there is an unmet clinical need for a new test to identify patients at risk of radiation toxicity. Here, we report a new approach based on Raman spectroscopy.Blood samples were collected from 42 patients who had undergone radiotherapy for prostate cancer and had shown either severe or no/minimal late radiation toxicity in follow up. Radiation response was assessed following in vitro irradiation using Raman spectroscopy in addition to the G2 chromosomal radiosensitivity assay and the H2AX DNA damage assay.A Partial Least Squares Discriminant Analysis model was developed to classify patients using known radiation toxicity scores. A sensitivity of 95%, specificity of 92% and overall accuracy of 93% was achieved. In the future, this technology may have potential to lead to individualised patient radiotherapy by identifying which patients are at risk of radiation toxicity

Vibrational Spectroscopy of Liquid Biopsies for Prostate Cancer Diagnosis

Background: Screening for prostate cancer with prostate specific antigen and digital rectal examination allows early diagnosis of prostate malignancy but has been associated with poor sensitivity and specificity. There is also a considerable risk of over-diagnosis and overtreatment, which highlights the need for better tools for diagnosis of prostate cancer. This study investigates the potential of high throughput Raman and Fourier Transform Infrared (FTIR) spectroscopy of liquid biopsies for rapid and accurate diagnosis of prostate cancer. Methods: Blood samples (plasma and lymphocytes) were obtained from healthy control subjects and prostate cancer patients. FTIR and Raman spectra were recorded from plasma samples, while Raman spectra were recorded from the lymphocytes. The acquired spectral data was analysed with various multivariate statistical methods, principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) and classical least squares (CLS) fitting analysis. Results: Discrimination was observed between the infrared and Raman spectra of plasma and lymphocytes from healthy donors and prostate cancer patients using PCA. In addition, plasma and lymphocytes displayed differentiating signatures in patients exhibiting different Gleason scores. A PLS-DA model was able to discriminate these groups with sensitivity and specificity rates ranging from 90% to 99%. CLS fitting analysis identified key analytes that are involved in the development and progression of prostate cancer. Conclusions: This technology may have potential as an alternative first stage diagnostic triage for prostate cancer. This technology can be easily adaptable to many other bodily fluids and could be useful for translation of liquid biopsy-based diagnostics into the clinic