Lymphocytic 5'-ectonucleotidase : a marker of psychological stress-induced immune suppression / Jane Blake-Mortimer.

Addendum inserted (leaf 170 verso)Some illustrations are on unnumbered leaves.Bibliography: leaves 151-170.xiv, 170, [25] leaves : ill. (some col.) ; 30 cm.Lymphocyte 5'-ectonucleotidase (NT) was selected as a mechanism to explain the phenomenon of stress-induced immunosuppression. The findings indicates that NT is a good marker of stress induced immune suppression and correlates negatively with depression scores such as the Beck Depression Inventory, and psychological distress as measured by the TMD scores, and STAI-trait. The suppression of NT appears to be mediated by reactive oxygen species (ROS), and is consistent with the finding of normal NT levels in melancholic patients with high antioxidant intake, the heightened inflammatory responses, the low levels of zinc, the low ascorbate stores, and the down regulation of glucocorticoid receptors reported to occur in stress/depressed patients.Thesis (Ph.D.)--University of Adelaide, Dept. of Psychology, 199

THE CREATIVE PSYCHOSOCIAL GENOMIC HEALING EXPERIENCE ©: ADMINISTRATION, RATIONALE, & RESEARCH. An Open Invitation to Mind-Body Psychotherapy Clinical & Experimental Research

Si tratta di un articolo pubblicato on line sul sito del Milton Erickson Institute of Californian Central Coast in cui si descrivono i fondamenti dell'espressione genica correlati al processo creativo a quattro stadi. Inoltre viene presentata una scala di valutazione dell'intervento clinico elaborata dal team internazionale di ricerca

Changes in clinically relevant metabolites with psychological stress parameters

Psychological stress is associated with increased oxidative stress, a pro-inflammatory state, increased rate of infection, and cardiovascular disease. Cardiovascular disease also is associated with increased stress, homocysteine, and C-reactive protein (CRP) levels. In this study, the authors measured various markers of psychological stress and correlated with homocysteine, CRP, salivary IgA, and oxidative stress. The results of the study showed that psychological stress is associated with pro-oxidant and pro-inflammatory states as evidenced by either decreased NT levels and/or increased CRP concentrations. Conversely, positive or low stress parameters, indicating good life skill mechanisms were associated with increased NT and decreased CRP--indications of a low pro-oxidant state. Homocysteine was associated with increased anger (anger-suppression and anger-experience), psychological parameters associated with cardiovascular disease and also mildly elevated CRP and homocysteine levels. Psychological well-being and stress are correlated with biochemical parameters both positively and negatively in relation to immunity and cardiovascular disease processes. The cross-sectional design and correlational approach used in this study preclude any inferences of causality but suggest several potentially useful avenues for future research