Avalia??o da associa??o entre n?veis de omentina s?rica e doen?a arterial coronariana em pacientes com s?ndrome metab?lica

Made available in DSpace on 2015-04-14T13:35:39Z (GMT). No. of bitstreams: 1 447907.pdf: 1330104 bytes, checksum: aa19b9b9e07f197ddc88c5cc8fef09c7 (MD5) Previous issue date: 2013-03-22Background: Visceral obesity is associated with increased risk of cardiovascular disease when compared to peripheral obesity. Omentin, an adipokine produced in the visceral adipose tissue, is related to components of metabolic syndrome (MetS) and may be related to coronary artery disease (CAD) Objective: To evaluate the association between serum levels of omentin and CAD in patients with MetS. Design and Methods: Serum levels of omentin were measured in 75 patients with MetS in a case-control study nested in a cross-sectional study. Thirty-six patients had CAD, whereas 39 patients did not have this disorder. Results: Serum levels of omentin were lower in patients with CAD than in those without the disease, 293.03 ng/mL ( } 121.44) and 224.56 ng/mL ( } 97.75), respectively (P = 0009). Serum levels of omentin were divided into 4 percentile groups. The highest percentile of omentin (Q4) had a lower proportion of CAD when compared to the lowest percentile (Q1). Such proportion did not change after adjusting for age, sex, HDL, type 2 diabetes, and diastolic blood pressure (OR: 0.13, CI: 0.02-0.84, P = 0.032).Introdu??o: Obesidade visceral esta associada a maior risco de doen?a cardiovascular, quando comparada a obesidade periferica. A omentina e uma adipocina produzida no tecido adiposo visceral e esta relacionada a fatores da Sindrome Metabolica (SM); e pode tambem estar relacionada a doenca arterial coronariana (DAC). Objetivo: Avaliar a associacao entre os niveis de omentina serica e doenca arterial coronariana em pacientes com Sindrome Metabolica. M?todos: A omentina serica foi avaliada em 75 pacientes com SM em estudo caso controle aninhado em um estudo transversal. Trinta e seis pacientes com doen?a arterial coronariana estabelecida e 39 pacientes sem doenca. Resultados: Os niveis sericos de omentina foram menores em pacientes com doenca arterial coronariana do que naqueles sem doenca, 293,03 ng/mL ( }121,44) e 224,56 ng/mL ( }97,75), respectivamente (P= 0.009). Niveis de omentina foram divididos em 4 grupos de percentis, e o maior percentil de omentina (Q4) teve menor proporcao de DAC do que o menor percentil (Q1), mesmo quando ajustados para idade e sexo, HDL, DM2 e PAD (OR:0,13, IC:0,02 a 0,84 ;P:0,032). Conclus?o: Em pacientes com SM, a omentina esta diminuida no grupo com DAC, e essa relacao parece estar inversamente proporcional aos niveis de omentina