Synthesis rifaximin with copper (Rif-Cu) and copper oxide (Rif-CuO) nanoparticles Considerable dye decolorization: An application of aerobic oxidation of eco-friendly sustainable approach

In this study, rifaximin with copper (Cu) and copper oxide (CuO) nanoparticles (NPs) were synthesised. The resultant CuO nanoparticles were used to degrade Rhodamine B (RhB) and Coomassie Brilliant Blue (G250). Rifaximin copper and copper oxide nanoparticles were characterised using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet–visible spectroscopy (UV), X-ray Photoelectron Spectroscopy (XPS), Transmission Electron Microscopy (TEM), and gas chromatography-electrochemical mass spectrometry (GC-EI-MS). An FT-IR study confirmed the formation of Cu in the 562 cm-1 peak range. Rifaximin Cu and CuO Nanoparticles displayed UV absorption peaks at 253 nm and 230 nm, respectively. Coomassie Brilliant Blue G250 was completely decolourised in Cu nanoparticles at 100 %, and Rhodamine B was also decolourised in Rifaximin CuO nanoparticles at 73 %, although Coomassie Brilliant Blue G250 Rifaximin Cu nanoparticles absorbed a high percentage of dye decolorization. The aerobic oxidation of isopropanol conversion was confirmed by GC-MS analysis. Retention time of 27.35 and 30.32 was confirmed using Cu and CuO nanoparticles as the final products of 2-propanone. It is used in the textile and pharmaceutical industries for aerobic alcohol oxidation. Rifaximin CuO nanoparticles highly active in aerobic oxidation. The novelty of this study is that, for the first time, rifaximin was used for the synthesis of copper and copper oxide nanoparticles, and it successfully achieved decolorization and aerobic oxidation

Synthesis and antibacterial activity of pyrano[3,2-g]chromene-4,6-dione derivatives and their molecular docking and DFT calculation studies

Pyran-4-one and chromenone are well known bioactive compounds, particularly antimicrobial activity. Present study investigation antibacterial activity of pyranone connected chromenone derivatives. New synthesis of pyrano[3,2-g]chromene-4,6-dione derivatives were synthesized via catalysis free eco-friendly method. Synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR, and mass spectral analysis. An entirely new synthesis of pyrano[3,2-g]chromene-4,6-dione derivatives (1a–o) were studied for their in vitro antibacterial properties. The gram-positive bacterium B. cereus was thought to be the most sensitive of the studied microorganisms, and compounds 1f, 1 g, 1 k, 1 l, and 1o demonstrated the best antibacterial action. The results of the antibacterial activities would suggest that 1 g was more effective against B. cereus (MIC: 0.5 μg/mL) than other compounds and Ciprofloxacin (MIC: 2 μg/mL). Against B. cereus bacterial pathogens, compound 1 g demonstrated exceptional antibacterial activity. The compound 1 g and Ciprofloxacin docked with 5V8E protein action of compound 1 g (-7.2 kcal/mol) and ciprofloxacin (-3.2 kcal/mol) is quite potent, and it also showed greater binding affinity. DFT calculation was well support the performance of energy gap between low and highly active compounds for 1 k (ΔE gap = 0.15 eV) and 1 g (ΔE gap = 0.16 eV), respectively. The lead molecules were used for antibacterial agent

Aerobic oxidation of aliphatic alcohol in cotton surface using epigallocatechin-3-gallate-iron (II, III) oxide (EGCG-Fe₃O₄) nanocatalyst from green tea extract

This study involved the synthesis of epigallocatechin-3-gallate-Iron (II, III) oxide (EGCG- Fe3O4) nanocatalysts by reacting Fe2O3 with EGCG extracted from green tea (Camellia sinensis) aqueous extract. This environmentally friendly method was used as an alternative to traditional synthesis routes. The EGCG- Fe3O4 nanocatalysts were characterised using various techniques, including fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), BET Surface area analysis, analysis and vibrating sample magnetometer (VSM). The results showed that the Fe3O4 nanocatalyst absorption peak at 363 nm indicated the formation of the Fe3O4 nanocatalyst, while the EGCG absorption peak shifted slightly to 274 nm, indicating the formation of the EGCG nanocatalyst. The conversion of final product aliphatic aldehyde from aliphatic alcohol in cotton surface via a solvent free aerobic oxidation using EGCG-Fe3O4 nanocatalyst. The final product of aliphatic aldehyde was confirmed by 1H and 13C NMR. The molecular weight of the product was determined by mass spectral characterisation (EI-MS), which showed a molecular ion m/z of 72.06 (M+, 100%), which was confirmed by the molecular weight of isobutyraldehyde conforming to the molecular mass using EI-MS mass spectral analysis. This method has been used for aerobic oxidation of aliphatic alcohols in the textile and pharmaceutical industries and offers several advantages, including the use of environmentally friendly reaction conditions, reduced catalyst concentrations, high product yields, affordability, absence of solvents, and recovery and reuse of the EGCG-Fe3O4 nanocatalyst.</p

DataSheet1_Mushroom tyrosinase enzyme catalysis: synthesis of larvicidal active geranylacetone derivatives against Culex quinquesfasciatus and molecular docking studies.pdf

The grindstone process, which uses tyrosinase as a catalyst, was used to create analogues of geranylacetone. Tyrosinase was used to prepare the Mannich base under favourable reaction conditions, resulting in a high yield. All synthesized compounds were characterized using FTIR, Nuclear magnetic resonance, and mass spectral analyses. The active geranylacetone derivatives (1a-l) were investigated for larvicidal activity against Culex quinquefasciatus; compound 1b (LD50:20.7 μg/mL) was noticeably more effective than geranylacetone (LD50: >100 μg/mL) and permethrin (LD50: 24.4 μg/mL) lead compounds because of their ability to kill larvae and use them as pesticides. All compounds (1a-1l) were found to be low toxic, whereas compounds 1b, 1d, and 1k were screened for antifeedant screening of non -aquatic target for the toxicity measurement against marine fish Oreochromis mossambicus at 100 μg/mL caused 0% mortality in within 24 h. Molecular docking studies of synthesised compound 1b and permethrin docked with 3OGN, compound 1b demonstrated a greater binding affinity (−9.6 kcal/mol) compared to permethrin (−10.5 kcal/mol). According to these results, the newly synthesised geranylacetone derivatives can serve as lead molecules of larvicides agents.</p