The presence of MIAC (a), histological chorioamnionitis (b), both MIAC and histological chorioamnionitis (c), and IAI (d) in PPROM with respect to cervical bacteria CSTs.

<p>Abbreviations: MIAC—microbial invasion of the amniotic cavity; IAI—intraamniotic infection;—preterm prelabor rupture of membranes; CST—community state type.</p

Heatmap of percentage abundance of selected species and remaining orders of the cervical microbiome of sixty-one women with PPROM.

<p>Ward linkage hierarchical clustering of Jensen-Shannon metrics identified four community state types (CST I, III, IV-A, and IV-B). The upper color bar shows the four community state types.</p

The cervical fluid IL-6 concentration levels in PPROM pregnancies according to cervical bacteria CSTs.

<p>Abbreviations: IL-6—interleukin-6; PPROM—preterm prelabor rupture of membranes; CST—community state type.</p

Bar chart of percentage abundance of selected species and remaining orders of bacteria in the cervical microbiota of sixty-one women with PPROM.

<p>Bar chart of percentage abundance of selected species and remaining orders of bacteria in the cervical microbiota of sixty-one women with PPROM.</p

Bacteria identified in the amniotic fluid of pregnancies complicated by PPROM.

<p>Abbreviations:</p><p>PPROM: Preterm prelabor rupture of membranes</p><p>CST: Community state type</p><p>Bacteria identified in the amniotic fluid of pregnancies complicated by PPROM.</p

Amniotic fluid IL-6 concentrations in women with PPROM complicated by MIAC with respect to cervical bacteria CST.

<p>Abbreviations: IL-6—interleukin-6; MIAC—microbial invasion of the amniotic cavity; PPROM—preterm prelabor rupture of membranes; CST—community state type.</p

Maternal and neonatal characteristics of PPROM pregnancies according to community state type of cervical microbiota.

<p>Abbreviations:</p><p>PPROM: Preterm prelabor rupture of membranes</p><p>IL-6: Interleukin-6</p><p>CRP: C-reactive protein</p><p>WBC: White blood cells</p><p>Continuous variables were compared using a nonparametric Jonckheere-Terpstra test. Categorical variables were compared using either Cochran-Armitage test for trend test. Statistically significant results are marked in bold.</p><p>Maternal and neonatal characteristics of PPROM pregnancies according to community state type of cervical microbiota.</p

Baseline characteristics of patients used in test and validation cohorts.

<p>ND = not defined, NA = not available</p><p>Baseline characteristics of healthy donors (HD), newly diagnosed multiple myeloma (MM) patients and patients with extramedullary myeloma (EM) used in a test and validation phase of the study. P values show differences in clinical parameters between studied groups, significant differences are marked in bold.</p

Correlation of serum miR-130a levels with clinically important biochemical parameters.

<p>Data are presented as coefficients of correlation. Statistically significant correlations are marked in bold and italics.</p

MiRNA levels in a validation cohort of patients.

<p>Data are presented as median of normalized miRNA expression and interquartile range. Mann-Whitney U test was used to compare the values. Fold change (FC) between extramedullary myeloma disease (EM) patients <i>versus</i> multiple myeloma (MM) patients and p values are presented. Significant values <i>p</i><0.05 are marked with bold and italics.</p