The Flynn effect in Korea: large gains

Secular gains in IQ test scores have been reported for many Western countries. This is the first study of secular IQ gains in South Korea, using various datasets. The first question is what the size of the Flynn effect in South Korea is. The gains per decade are 7.7 points for persons born between 1970 and 1990. These gains on broad intelligence batteries are much larger than the gains in Western countries of about 3 IQ points per decade. The second question is whether the Korean IQ gains are comparable to the Japanese IQ gains with a lag of a few decades. The gains in Japan of 7.7 IQ points per decade for those born approximately 1940 1965 are identical to the gains per decade for Koreans born 1970 1990. The third question is whether the Korean gains in height and education lag a few decades behind the Japanese gains. The Koreans reach the educational levels the Japanese reached 25 30 years before, and the gains in height for Koreans born 1970 1990 are very similar to gains in height for Japanese born 1940 1960, so three decades earlier. These findings combined strongly support the hypothesis of similar developmental patterns in the two countries

Does cultural background influence the intellectual performance of children from immigrant groups?

This paper addresses both the construct validity and the criterion-related validity of the "Revisie Amsterdamse Kinder Intelligentie Test" (RAKIT), which is a cognitive ability test developed for primary school children. The present study compared immigrant primary school children (N = 559) and Dutch children (N = 604). The mean scores of Surinamese/Netherlands Antillean, Moroccan, and Turkish children differed from each other and were lower than those of the Dutch children. Comparison of the test dimensions showed that group differences with respect to the construct validity were small. We found some item bias, but the combined effects on the sum score were not large. The estimate of general intelligence (g) as computed with the RAKIT showed strong predictive validity for most school subjects and standardized achievement tests. Although some criteria revealed significant prediction bias, the effects were very small. Most of the analyses we performed on differences in test scores and differences in criterion scores supported Spearman's hypothesis that g is the predominant factor determining the size of the differences between two groups. The conclusion that the RAKIT can be used for the assessment of groups from various backgrounds seems warranted

Increased serum interferon activity in sarcoidosis compared to that in tuberculosis:Implication for diagnosis?

Objectives: In this study, we measured serum interferon (IFN) levels and activity in patients with sarcoidosis and tuberculosis (TB) with and without uveitis. We aimed to understand the role of IFN in the pathophysiology of both conditions and explore its potential as a discriminating marker for these clinically similar diseases. Methods: Sera from an Indonesian TB and a Dutch sarcoidosis cohort were used in the analysis. IFNα2 and IFNγ concentrations were measured using Simoa® and Luminex assays, respectively. Serum IFN activity was assessed by incubating THP-1 cells with patient serum and measuring IFN-stimulated gene transcription using qPCR. Anti-IFNα2 and IFNγ autoantibodies were detected via Luminex assay and tested for neutralizing capacity using a flow cytometry-based signal transducer and activator of transcription (STAT) 1 phosphorylation inhibition assay. Results: IFNα2 was detected in 74 % and 64 % of patients with sarcoidosis and pulmonary TB, respectively, while IFNγ was found in 78 % and 23 % of patients with sarcoidosis and TB, respectively. For uveitis cases specifically, IFNα2 was detected in 85 % of sarcoid uveitis (SU) and 33 % of tubercular uveitis (TBU) cases. Similarly, IFNγ was detected in 69 % of SU and 17 % of TBU cases. IFNγ serum concentrations were higher in sarcoidosis than that in TB patients (p &lt; 0.0001). Focusing on patients with uveitis, SU showed increased IFNα2 (p = 0.004) and IFNγ (p &lt; 0.002) serum concentrations compared to that in TBU. Notably, TBU displayed significantly reduced IFNα2 concentrations compared to that in healthy controls (p = 0.006). These results align with the increased interferon stimulated gene (ISG) transcriptional upregulation observed in THP-1 cells stimulated with serum from patients with sarcoidosis. Elevated levels of non-neutralizing anti-IFN autoantibodies were observed in patients with TB; however, these levels were similar to those observed in geographically matched healthy Indonesian controls. Conclusion: Our results suggest decreased serum levels and activity of type I and II IFN in TB compared to those in sarcoidosis. This is indicative of distinct pathophysiological processes in these highly clinically similar diseases. We propose that the assessment of serum IFN levels and IFN activity has the potential to distinguish between sarcoidosis/SU and TB/TBU.</p

The Role of Thrombin in Proliferative Vitreoretinopathy

PURPOSE. To determine the role of thrombin in the development of proliferative vitreoretinopathy (PVR). METHODS. Vitreous was collected from patients undergoing a vitrectomy (macular holes and puckers, n ¼ 11 [controls]; retinal detachment without PVR development following vitrectomy, n ¼ 15 [RRD1]; retinal detachment with PVR development within 6 months after vitrectomy, n ¼ 11 [RRD2]; and established PVR, n ¼ 14 [PVR]). Thrombin activity in vitreous was determined using a thrombin-specific chromogenic substrate. ARPE-19 cells were stimulated with 83 diluted vitreous samples in the presence and absence of hirudin. The samples were analyzed at t ¼ 0 and t ¼ 24 hours for the presence of 27 cytokines/ chemokines and growth factors using a multiplex approach. In comparable studies, ARPE-19 cells were stimulated for 2 hours, and mRNA expression levels for CCL2, CXCL8, GMCSF, IL6, and PDGFB were determined by real-time quantitative (RQ)-PCR. RESULTS. Thrombin activity was significantly (P &lt; 0.05) higher in vitreous of the PVR group compared to the other groups. Proliferative vitreoretinopathy vitreous stimulated the production of chemokine (C-C motif) ligand (CCL)2, chemokine (C-X-C motif) ligand (CXCL)8, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, and plateletderived growth factor (PDGF)-BB by ARPE-19 to significantly (P &lt; 0.05) higher levels than vitreous from the RRD1 and RRD2 groups. These effects of PVR vitreous were significantly (P &lt; 0.05) reduced by hirudin. These data were confirmed by mRNA studies. CONCLUSIONS. Thrombin activity is increased in vitreous of patients with established PVR and is involved in the activation of proinflammatory and profibrotic pathways in RPE cells. Inhibition of thrombin activity may therefore represent a potential treatment option for proliferative vitreoretinopathy

Spearman’s Hypothesis Tested on Black Adults: A Meta-Analysis

Blacks generally score significantly lower on intelligence tests than Whites. Spearman’s hypothesis predicts that there will be large Black/White differences on subtests of high cognitive complexity, and smaller Black/White differences on subtests of lower cognitive complexity. Spearman’s hypothesis tested on samples of Blacks and Whites has consistently been confirmed in many studies on children and adolescents, but there are many fewer studies on adults. We carried out a meta-analysis where we collected the existing tests of Spearman’s hypothesis on adults and collected additional datasets on Black and White adults that could be used to test Spearman’s hypothesis. Our meta-analytical search resulted in a total of 10 studies with a total of 15 datapoints, with participants numbering 251,085 Whites and 22,326 Blacks in total. For all these data points, the correlation between the loadings of a general factor that is manifested in individual differences on all mental tests, regardless of content (g) and standardized group differences was computed. The analysis of all 15 data points yields a mean vector correlation of 0.57. Spearman’s hypothesis is confirmed comparing Black and White adults. The differences between Black and White adults are strongly in line with those previously found for children and adults; however, because of lack of access to the original data, we could not test for measurement invariance

Does Blindness Boost Working Memory?:A Natural Experiment and Cross-Cultural Study

Intelligence requires sufficient working-memory capacity. Traditionally, working memory was seen as a process and as a prerequisite for fluid intelligence. Working memory was assumed to be determined by maturation and health. There is a gap in the literature: It is still not fully understood to which extent and how working memory can be influenced. So this study tested how visual impairment and the extent of visual impairment are related to working memory capacity. In our study we compared N = 249 children (6–16 years) with and without visual impairment (blind, visually impaired, and sighted) in two countries (South Africa and Austria) at different development levels on their working-memory capacity and verbal comprehension. Using the WISC-IV, blind and visually impaired children showed higher working-memory capacity than sighted children (r = + 0.35, 14, and 3 IQ points, respectively). On the other hand, visually impaired children showed a weakness in verbal comprehension (r = −0.39, on average 13 IQ points lower). The pattern remained robust when SES and race-ethnicity were controlled. Our natural (quasi-)experiment shows a pattern, which is unlikely to be genetic, and so supports the view that working memory and intelligence scores can be modified

A Meta-Analysis of Spearman’s Hypothesis Tested on Latin-American Hispanics, Including a New Way to Correct for Imperfectly Measuring the Construct of g

Spearman’s hypothesis states that the difference in intelligence between groups is a function of the g loadings of the subtests, where larger differences are found on tests with higher g loadings. This finding has consistently been supported on various groups. In this study we look at samples of Latin-American Hispanics in comparison to Whites. We carried out a meta-analysis based on 14 data points and a total of 16,813 Latin-American Hispanics, including a new way to correct for imperfectly measuring the construct of g. Spearman’s hypothesis was strongly supported with a mean r of 0.63. After correction for various statistical artifacts this value became rho = 0.91. Therefore, we conclude that Spearman’s hypothesis also holds true for White/Latin-American Hispanic differences

Are adoption gains on the g factor? A meta-analysis

When children are adopted into prosperous families they generally show IQ gains. The meta-analytic orrelation between subtest g loadings and adoption gains is examined (K = 4, combined N = 3018). A number of meta-analytic corrections are applied to the estimate, yielding a correlation of -1. The results are discussed. (C) 2014 Elsevier Ltd. All rights reserve

Are Headstart gains on the g factor? A meta-analysis

Headstart studies of compensatory education tend to show impressive gains on IQ scores for children from low-quality environments. However, are these gains on the g factor of intelligence? We report a meta-analysis of the correlation between Headstart gains on the subtests of IQ batteries and the g loadings of these same subtests (K = 8 studies, total N = 602). A meta-analytic sample-weighed correlation of -.51 was found, which became -.80 after corrections for measurement error. We conclude that the pattern in Headstart gains on subtests of an IQ battery is highly similar to the pattern in test-retest gains and is hollow with respect to g. So, Headstart leads to gains in IQ scores, but not to gains in g. We discuss this finding in relation to the Flynn effect, training effects, and heritability. (C) 2014 Elsevier Inc. All rights reserve