Top criteria which impact trial eligibility.

<p>Top criteria which impact trial eligibility.</p

Safety in real world patients who would be eligible and ineligible for registration trials.

<p>The bars represent the proportion of patients who experienced a serious adverse event or adverse event in patients eligible or ineligible for registration trials.</p

Set of general eligibility criteria.

<p>Set of general eligibility criteria.</p

Baseline characteristics.

<p>Baseline characteristics.</p

Effectiveness in real world treatment naive and relapse patients who would be eligible and ineligible for registration trials.

<p>Primary and sensitivity analyses on effectiveness of therapy in eligible vs. ineligible naive and relapse patients (n = 348). The bars represent the proportion of patients who reached a sustained virological response (SVR) within the groups. For sensitivity analyses different criteria sets are used to determine eligibility of patients, hence different numbers of patients in both groups.</p

Incidence of specific (serious) adverse events in eligible and ineligible patients.

<p>The bars represent the incidence of various categories of (serious) adverse events between patients eligible and ineligible for registration trials. The asterix (*) marks significant differences between eligible and ineligible patients.</p