Distribution of SNP344 genotypes in cancer patients and healthy controls.

<p>Distribution of SNP344 genotypes in cancer patients and healthy controls.</p

Distribution of SNP344 genotypes in cancer patients and healthy controls, restricted to individuals carrying the SNP309T-allele.

<p>Distribution of SNP344 genotypes in cancer patients and healthy controls, restricted to individuals carrying the SNP309T-allele.</p

SNP344 and mdm2 expression.

<p>Box-plots representing log transformed relative levels of total MDM2 mRNA (<b>A</b>) and promoter P2 specific mRNA (<b>B</b>) in individuals harbouring the SNP344TT genotype versus the TA and AA genotypes.</p

Effect of SNP344 status on transcription factor binding to MDM2 promoter P2.

<p>Effect of SNP344 status on transcription factor binding to MDM2 promoter P2.</p

Impact of SNP344A on cancer risk.

<p>Forrest plot showing the effect of SNP344A on risk of ovarian, breast, endometrial and prostatic cancer, as compared to healthy controls, among individuals harbouring the SNP309TG genotype (A), the SNP309TT genotype (B) and the TG and TT genotypes combined (C).</p