Five-year overall survival among laryngeal patients by serum selenium levels.

<p>Five-year overall survival among laryngeal patients by serum selenium levels.</p

Hazard ratios and 95% confidence intervals for various factors on survival from laryngeal cancer.

<p>Hazard ratios and 95% confidence intervals for various factors on survival from laryngeal cancer.</p

Characteristics of the study population (n = 296).

<p>Characteristics of the study population (n = 296).</p

Age- and sex-adjusted hazard ratios and 95% confidence intervals for low (quartile 1) versus high (quartile 4) serum selenium levels on survival from laryngeal cancer.

<p>Age- and sex-adjusted hazard ratios and 95% confidence intervals for low (quartile 1) versus high (quartile 4) serum selenium levels on survival from laryngeal cancer.</p

Serum folate concentration and the incidence of lung cancer

<div><p>Background</p><p>Lung cancer is a leading cause of cancer-related mortality globally. Folate helps to maintain DNA integrity and to regulate gene expression. Serum folate levels may affect the risk of several cancers, including lung cancer. In this study we evaluated the association between serum folate concentration and variations in genes involved in folate metabolism with lung cancer incidence in Poland.</p><p>Methods</p><p>The study included 366 lung cancer patients and 366 control subjects. We measured serum folate concentration and genotyped six variants in <i>MTHFR</i>, <i>MTR</i> and <i>MTRR</i> genes. The odds ratios of being diagnosed with lung cancer were calculated using conditional univariable and multivariable logistic regression with respect to folate level and genotypes.</p><p>Results</p><p>The mean serum folate level was lower in lung cancer cases than in control group (20.07 nmol/l vs. 22.52 nmol/l, p = 0.002). The odds ratio for lung cancer declined with increasing serum content of the folate. The folate concentration of >25.71 nmol/l (IVth quartile) in comparison to <15.92 nmol/l (Ist quartile) was associated with an odds ratio of 0.61 (95%CI 0.40–0.95, p = 0.03). The analysis of variations in <i>MTHFR</i>, <i>MTR</i> and <i>MTRR</i> genes did not reveal any significant difference between lung cancer cases and controls in univariable and multivariable analyses.</p><p>Conclusion</p><p>In this case-control study, lower serum folate concentrations were associated with a higher risk of lung cancer diagnosis. Although previous findings have been somewhat mixed, our results add to the evidence that circulating folate levels may be an indicator of lung cancer risk.</p></div

Characteristic of lung cancer cases and controls.

<p>Characteristic of lung cancer cases and controls.</p

Serum folate concentration and odds ratio curve of developing lung cancer.

<p>Odds ratio curve of developing lung cancer for folate concentration (nmol/l) shown for a sliding approach (window size: 30 observations). Values above the line indicate an increased probability, values below indicate a decreased probability of developing lung cancer. The reference proportions is 1:1 for the entire series. A Lowest-regression was applied to those calculated data point to estimate the underlying probability curve.</p

Folate concentration and lung cancer incidence.

<p>Folate concentration and lung cancer incidence.</p

Characteristics of Cases and Controls for Laryngeal Cancer Study.

<p>Characteristics of Cases and Controls for Laryngeal Cancer Study.</p

Serum selenium levels and the risk of laryngeal cancer.

<p>Serum selenium levels and the risk of laryngeal cancer.</p