Effect of pre-treatment with AMPH on DAT and DRD1 binding (autoradiography).

<p>Effect of pre-treatment with AMPH on DAT and DRD1 binding (autoradiography).</p

ROI analyses of phMRI data.

<p>phMRI time courses in the CPu (a) and NAcc (b). MPH or saline challenge was administered after 12 volumes (indicated by the arrow) followed by 38 volumes post-administration. The AMPH-MPH group differed significantly from the SAL-MPH and SAL groups. Difference between pre-injection (1–12) and post-injection (15–35) displayed for the CPU and Nacc (c) for each group (mean ±SEM)* p<0.05.</p

Effect of pre-treatment with AMPH on brain monoamines and metabolites.

<p>Effect of pre-treatment with AMPH on brain monoamines and metabolites.</p

Whole brain analyses of phMRI data.

<p>The three rows show 1 mm-thick coronal slices for different group comparisons: a) MPH challenge in saline-treated rats increased BOLD response compared to groups that received a saline challenge b) MPH challenge in AMPH-pre-treated rats increased the BOLD response extensively c) AMPH-pre-treated rats show increased BOLD response compared to the SALMPH group. Images are thresholded at Z = 1.6.</p

Immunocytochemistry.

<p>a) GFAP b) DRD1 c) DAT and d) DRD2 expression following AMPH or saline pre-treatment in the NAcc and CPu (mean ±SEM) * p<0.05.</p