Copeptin levels and characteristics of study patients.

<p>IQR: interquartile range; WFNS: World Federation of Neurological Surgeons; ICH: intracerebral hemorrhage; IVH: intraventricular hemorrhage.</p>a<p>WFNS grade: Good-grade WFNS 1–3; Poor-grade: WFNS 4–5.</p>b<p>modified Rankin Scale (mRS) score 0–3: Good outcome; mRS 4–6: Poor outcome.</p

Copeptin Level by WFNS Grade.

<p>The figure represents a boxplot of copeptin values per WFNS grade. Displayed are lowest, highest and median copeptin values (pmol/L), with upper (75%) and lower (25%) quartiles.</p

SWI Serial images of a patient with PSE.

<p>Globally diminished corticals veins due to global hyperperfusion in patients with NCSE or PSE is a new finding of this study. This is an example of a 78 y old female with NCSE (patient no. 11). Cortical veins are not visible in the minimum intensity projection SW images.</p

Detailed patient data.

<p>Detailed information on patients including underlying seizure pathology, findings in SWI, perfusion imaging and DWI. Division of patients according to the findings in SWI and perfusion imaging: patients 1–8, group 1; patients 9–15, group 2; patients 16–23, group 3; patients 24–26, group 4.</p

Scatter plot of quantified CBF.

<p>Each patient group is represented in an oval: group 1, blue oval; group 2, green oval; group 3, grey oval; group 4, purple oval. x-axis (CBF1): CBF value in ml/100 g/min of ill-perfused parenchyma y-axis (CBF2): CBF value in ml/100 g/min of the contralateral side. Group 1 shows a global hyperperfusion with mostly high CBF values in both hemispheres (x- and y-axis: >75 ml/100 g/min). Groups 2 and 3 show mainly unilateral higher CBF values (x-axis: >75 ml/100 g/min) and mostly normal CBF values on the opposite side (y-axis: around 50 ml/100 g/min). For group 4, CBF values are low in the ill-perfused area (x-axis: <50 ml/100 g/min), while the CBF values on the contralateral side are mostly in the normal range (y-axis: around 50 ml/100 g/min).</p

Overview of group findings.

<p>Division of patients into groups according to the findings in SWI and perfusion imaging.</p

Outcomes in smoking vs. non-smoking stroke patients after endovascular treatment.

<p>Results are expressed in n/N (%). CI confidence interval, mRS modified Rankin Scale, OR odds ratio, sICH symptomatic intracranial hemorrhage. ¹ adjusted for age, sex, NIHSS on admission, systolic blood pressure on admission, stroke etiology, localization of occluded vessel, hypercholesterolemia and use of antithrombotic pretreatment.</p

Modified Rankin Scale at 3 months.

<p>Modified Rankin Scale at 3 months.</p

Comparison between antiplatelet naïve patients and patients with prior and/or acute antiplatelet therapy^†.

<p>Comparison between antiplatelet naïve patients and patients with prior and/or acute antiplatelet therapy<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0170045#t004fn002" target="_blank">^†</a>.</p

Baseline characteristics and vascular risk factors.

<p>Baseline characteristics and vascular risk factors.</p