Baseline clinical and biochemical characteristics of patients and controls.

<p>The data are presented as mean ±SD, median (25^th, 75^th percentile), or numbers (%). SA =  stable angina; ACS =  acute coronary syndrome; MI =  myocardial infarction; LDL =  low density lipoprotein, HDL =  high density lipoprotein. NS =  non-significant (p≥0.05). For comparisons between groups, p-values indicating significant differences are denoted by ψ (controls vs SA), γ (controls vs NSTE-ACS) and <i>Φ</i> (SA vs NSTE-ACS), respectively.</p><p>Baseline clinical and biochemical characteristics of patients and controls.</p

Different plaque compositions as seen by CCTA.

<p>The different types of coronary plaque are shown in longitudinal views, with cross-sectional views at the level of the dotted line. A non-calcified plaque is shown on the left (A and B), with white arrowheads pointing at the non-calcified plaque component. A mixed plaque is shown in the middle (C and D), with a white arrowhead indicating the non-calcified plaque component and a black arrowhead indicating the calcified component. A large calcified plaque is shown on the right side (E and F), with black arrowhead indicating the calcifications.</p

Baseline leukocyte subsets and plasma cytokines of patients and controls.

<p>The data are presented as mean ±SD or median (25^th, 75^th percentile). SA =  stable angina; NSTE-ACS =  non-ST-elevation acute coronary syndrome; CD19+ cells, B cells; CD4+ cells, T helper cells; CD8+ cell, cytotoxic T cell; NK =  Natural killer; IL =  interleukin; CRP =  C-reactive protein. NS =  non-significant (p≥0.05). For comparisons between groups, p-values indicating significant differences are denoted by ψ (controls vs SA), γ (controls vs NSTE-ACS) and <i>Φ</i> (SA vs NSTE-ACS), respectively.</p><p>Baseline leukocyte subsets and plasma cytokines of patients and controls.</p

Correlation plots.

<p>A. Direct flow (DF) volume ratio (in relation to LVEDV) versus LVEDV index (LVEDVI). B. DF Kinetic energy (KE) ratio at ED versus LVEDVI. C. Non-ejecting (NE) volume ratio versus LVEDVI. D. NE KE ratio at ED versus LVEDVI.</p

Sub-analysis with patients stratified according to Late Gadolinium Enhancement test.

<p>Sub-analysis with patients stratified according to Late Gadolinium Enhancement test.</p

4D flow components.

<p>A. Schematic of the routes of the four LV flow components; direct flow (green), retained inflow (yellow), delayed ejection flow (blue), and residual volume (red). A semitransparent grayscale three-chamber image provides morphological orientation. Circles indicate the approximate location of the center of mass of each component at the time of end-diastole. B. Particle trace pathlines indicate routes of direct flow (green) and retained inflow (yellow). Red dots indicate the positions of the residual volume pathlines at end-diastole. Non-ejected flow comprises the retained inflow and the residual volume. Ao, aorta; LA, left atrium; LV, left ventricle.</p

The 4D flow components as proportions of total LV EDV (percent ± SD) in the three sub-groups stratified by LVEDVI.

<p>Non-ejecting volume is comprised of the Retained inflow (yellow) and Residual volume (red) flow components (yellow + red = orange). * P<0.05 vs Control group; † P<0.05 vs Lower LVEDVI group.</p

Correlation between 4D flow measures and LV volumes.

<p>Correlation between 4D flow measures and LV volumes.</p

Additional file 1 of Association between left ventricular systolic function parameters and myocardial injury, organ failure and mortality in patients with septic shock

Additional file 1: Table S1. Comparison of the Septic Heart cohort and the Sepsis in the ICU 2 cohort. Table S2. Patient characteristics at the time of echocardiography for all patients and stratified by myocardial injury. Table S3. Sensitivity analysis excluding patients with atrial fibrillation. Echocardiographic parameters for all patients and stratified by myocardial injury. Table S4. Sensitivity analysis excluding patients with atrial fibrillation. Independent relationship between echocardiographic variables and myocardial injury. Echocardiographic variables (either LVEF, s´, LVLS, MAPSE or LV-LWFS) were included in 5 separate multivariable models adjusted for age, previous cardiac disease, SOFA score, SAPS3 score, creatinine and RV systolic dysfunction. Table S5. PRICES checklist items