Kaplan-Meier analysis of survival in a cohort of IPF patients.

<p>(A) Carriers of the <i>TP53</i> rs12951053 C or rs12602273 G alleles had significantly worse 4-year survival rate (p = 0.006). (B) There was no significant difference in survival between carriers and non-carriers of the <i>CDKN1A</i> rs2395655 G allele (p = 0.2).</p

<i>TP53</i> genotype frequency in patients and controls.

<p>The values in parentheses are the number of individuals the frequency is based on.</p><p>There were no significant differences between patients and controls.</p

Linkage disequilibrium plot.

<p>Showing pairwise r² for SNPs in <i>TP53</i> (A) and <i>CDKN1A</i> (B).</p

<i>CDKN1A</i> mRNA expression in healthy controls.

<p><i>CDKN1A</i> mRNA levels were significantly different between rs733590 genotypes, p = 0.03 (TT+CT vs. CC). A similar trend was observed for rs2395655 genotypes (p = 0.06, AA+AG vs. GG).</p

Genotype and lung function decline.

<p>Number of IPF patients with non-rapid or rapid decline in %predicted vital capacity (>10% in one year) or %predicted diffusion capacity (>15% in one year).</p><p>*Fisher's exact test with carriers of p21 rs2395655G vs. non-carriers resulted in p = 0.04.</p

<i>CDKN1A</i> genotype and carriership frequency in patients and controls.

<p>The values in parentheses are the number of individuals. P values are based on the number of individuals with and without the specified genotype and are calculated using a Pearson's goodness-of-fit chi-square test. Odds ratio (OR) is shown with the 95% confidence interval in brackets.</p><p>*After correction for multiple testing rs733590 and rs2395655 remained significant.</p

Predictive value of YKL-40 and CCL18 for pneumonia caused by intracellular bacteria using univariate and multivariate logistic regression analysis.

<p>Predictive value of YKL-40 and CCL18 for pneumonia caused by intracellular bacteria using univariate and multivariate logistic regression analysis.</p

Serial levels of the four pulmonary markers in 291 patients hospitalised with community-acquired pneumonia and in 20 healthy controls.

<p>Serial levels of the four pulmonary markers in 291 patients hospitalised with community-acquired pneumonia and in 20 healthy controls.</p

Change in log normally-transformed pulmonary marker levels over time for each aetiological group.

<p>Data are shown as estimated marginal means with 95% confidence intervals.</p

Change in log normally-transformed pulmonary marker levels over time for pneumonia severity index score.

<p>Data are shown as estimated marginal means with 95% confidence intervals.</p