99 research outputs found
Developing sensor technology innovations with business potential together with students: let's return to the master-apprentice approach
Presentation of connected pape
Quantified Self: Groningen zet stappen
Of het nu gaat om het kwantitatief in kaart brengen van het beweeggedrag van een groep kinderen, het overbrengen van kennis over lichaamsbeweging of het creëren van bewustwording over gezond beweeggedrag, er liggen tal van kansen om met nieuwe technologie het vak bewegingsonderwijs te verrijken. In dit artikel is beschreven op welke wijze het project 'Groningen zet stappen' dit in de praktijk heeft toegepast
Single and multigland disease in primary hyperparathyroidism: Clinical follow-up, histopathology, and flow cytometric DNA analysis
Two-hundred seventy-four patients with primary hyperparathyroidism had selective removal of enlarged parathyroid glands. Biopsies were taken from all parathyroid glands. Normal-size glands were not resected irrespective of their histological appearance. After a mean follow-up of 13.5 years the rates of persistent and recurrent hyperparathyroidism were, respectively, 3.6% and 0.7%. Transient and permanent hypoparathyroidism occurred in 24% and 2.5% of the patients. The microscopic appearance of enlarged glands and of biopsies taken from normal-size glands were reviewed by two pathologists. Normal parathyroid glands were distinguished from abnormal glands fairly accurately (sensitivity 93%, specificity 80%). Microscopic classification of abnormal parathyroid glands as adenomas or hyperplastic glands correlated poorly with the gross classification as single or multigland disease. Flow cytometric DNA analysis of paraffin embedded parathyroid tissue showed significant differences for DNA index, % S-phase and % G2M (p<0.001). Differentiating single from multigland disease by means of DNA analysis was not possible. In conclusion, removal of only enlarged parathyroid glands results in acceptable rates of persistent and recurrent hyperparathyroidism. Biopsies should only be taken sparingly to prevent transient and permanent hypoparathyroidism. Microscopic examination and flow cytometric DNA analysis can differentiate normal from abnormal parathyroid glands but are unable to differentiate abnormal glands into single or multigland disease
Fertility and body composition after laparoscopic bilateral adrenalectomy in a 30-year-old female with congenital adrenal hyperplasia
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is caused
by an inborn defect in the 21-hydroxylase gene (CYP21), leading to
virilization of female patients and causing ambiguous genitals in the
majority of female infants. Adult women may suffer from loss of libido,
irregular or absent cycles, and reduced fertility, despite intensive
medical treatment. These problems have stimulated the search for
alternative treatment modalities. We present an adult female patient, who
was difficult to treat medically and whose clinical situation markedly
improved after laparoscopic bilateral adrenalectomy. The procedure was
well tolerated and without side effects. Postoperatively the elevated
serum progesterone and 17-hydroxyprogesterone levels, as well as the
undetectable LH levels, normalized. The procedure resulted in marked
clinical improvement. Within 12 months after surgery she lost 11 kg in
weight. This weight loss consisted mainly of adipose tissue. Acne
disappeared, and she had a regular 4-week menstrual cycle, with
progesterone levels that are compatible with a luteal phase. The
introduction of laparoscopic techniques may give an impulse to the
application of surgical therapy at a larger scale in patients with
21-hydroxylase deficiency who are difficult to treat with adrenal
suppression therapy
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