Chronic eccentric exercise and antioxidant supplementation: effects on lipid profile and insulin sensitivity

Eccentric exercise has been shown to exert beneficial effects in both lipid profile and insulin sensitivity. Antioxidant supplementation during chronic exercise is controversial as it may prevent the physiological training-induced adaptations. The aim of this study was to investigate: 1) the minimum duration of the eccentric exercise training required before changes on metabolic parameters are observed and 2) whether antioxidant supplementation during training would interfere with these adaptations. Sixteen young healthy men were randomized into the Vit group (1 g of vitamin C and 400 IU vitamin E daily) and the placebo (PL) group. Subjects received the supplementation for 9 weeks. During weeks 5-9 all participants went through an eccentric exercise training protocol consisting of two exercise sessions (5 sets of 15 eccentric maximal voluntary contractions) per week. Plasma triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoproteins (Apo A1, Apo B and Lpa) and insulin sensitivity (HOMA) were assessed before the supplementation (week 0), at weeks 5, 6, 7, 8 and 9. TG, TC and LDL were significantly lower compared to pre supplementation at both weeks 8 and 9 (P<0.05) in both groups. HDL was significantly elevated after 4 weeks of training (p < 0.005) in both groups. There was no effect of the antioxidant supplementation in any of the variables. There was no effect of either the training or the supplementation protocol in apolipoproteins levels and insulin sensitivity. A minimum duration of 3 weeks of eccentric exercise training is required before beneficial effects in lipid profile can be observed in healthy young men. Concomitant antioxidant supplementation does not interfere with the training-induced adaptations

Functional responses of uremic single skeletal muscle fibers to redox imbalances

BACKGROUND: The exact causes of skeletal muscle weakness in chronic kidney disease (CKD) remain unknown with uremic toxicity and redox imbalances being implicated. To understand whether uremic muscle has acquired any sensitivity to acute redox changes we examined the effects of redox disturbances on force generation capacity. METHODS: Permeabilized single psoas fibers (N =37) from surgically induced CKD (UREM) and sham-operated (CON) rabbits were exposed to an oxidizing (10 mM Hydrogen Peroxide, H2O2) and/or a reducing [10 mM Dithiothreitol (DTT)] agent, in a blind design, in two sets of experiments examining: A) the acute effect of the addition of H2O2 on maximal (pCa 4.4) isometric force of actively contracting fibers and the effect of incubation in DTT on subsequent re-activation and force recovery (N =9 CON; N =9 UREM fibers); B) the effect of incubation in H2O2 on both submaximal (pCa 6.2) and maximal (pCa 4.4) calcium activated isometric force generation (N =9 CON; N =10 UREM fibers). RESULTS: Based on cross-sectional area (CSA) calculations, a 14 % atrophy in UREM fibers was revealed; thus forces were evaluated in absolute values and corrected for CSA (specific force) values. A) Addition of H2O2 during activation did not significantly affect force generation in any group or the pool of fibers. Incubation in DTT did not affect the CON fibers but caused a 12 % maximal isometric force decrease in UREM fibers (both in absolute force p =0.024, and specific force, p =0.027). B) Incubation in H2O2 during relaxation lowered subsequent maximal (but not submaximal) isometric forces in the Pool of fibers by 3.5 % (for absolute force p =0.033, for specific force p =0.019) but not in the fiber groups separately. CONCLUSIONS: Force generation capacity of CON and UREM fibers is affected by oxidation similarly. However, DTT significantly lowered force in UREM muscle fibers. This may indicate that at baseline UREM muscle could have already been at a more reduced redox state than physiological. This observation warrants further investigation as it could be linked to disease-induced effects

Effects of acute exercise on liver function and blood redox status in heavy drinkers

Excessive alcohol consumption can induce oxidative stress, resulting in the development of several diseases. Exercise has been reported to prevent and/or improve a number of health issues through several mechanisms, including an improvement in redox status. It has also been previously suggested that exercise can help individuals with alcohol use disorders reduce their alcohol intake; however, research in this field is limited. The aim of the present study was to investigage the effects of acute exercise of moderate intensity on the liver function and blood redox status in heavy drinkers. For this purpose, a total of 17 heavy drinkers [age, 31.6±3.2 years; body mass index (BMI), 27.4±0.8 kg/m2; experimental group (EG)] and 17 controls [age, 33.5±1.3 years; BMI, 26.1±1.4 kg/m2; control group (CG), who did not exceed moderate alcohol consumption], underwent one trial of acute exercise of moderate intensity (50-60% of the heart rate reserve) for 30 min on a cycle ergometer, following an overnight fast, and abstaining from smoking and alcohol consumption. Blood samples were obtained before and immediately after exercise for later determination of the indices of liver function and blood redox status. The subjects in the EG had significantly higher (p<0.05) baseline γ-glutamyl transferase (γ-GT) levels compared to the subjects in the CG. Exercise thus resulted in significantly higher γ-GT levels (p<0.005) only in the EG. No significant differences in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) baseline levels were observed between the 2 groups. Following exercise, the AST levels increased significantly (p<0.001) in both groups, whereas the ALT levels increased significantly (p<0.01) only in the EG. The baseline glutathione (GSH) levels were significantly lower (p<0.05) and remained low following exercise in the EG. In addition, we observed a trend for higher (p=0.07) baseline levels of thiobarbituric acid-reactive substances (TBARS), which remained elevated post-exercise in the EG compared to the CG. Significantly increased post-exercise total antioxidant capacity (TAC; p<0.01) and uric acid (UA; p<0.05) levels were noted in the CG, whereas the TAC (p=0.06) and UA (p=0.08) levels increased and approached significance post-exercise in the EG. No significant differences in the baseline levels of total bilirubin and protein carbonyl were observed between the 2 groups, even post-exercise. Thus, the findings of the present study indicate that even though heavy drinkers may be prone to oxidative stress, their exercise-induced antioxidant response is similar to that of individuals who do not drink heavily.Interna

Insights into the molecular etiology of exercise-induced inflammation: Opportunities for optimizing performance

The study of exercise-induced muscle damage (EIMD) is of paramount importance not only because it affects athletic performance but also because it is an excellent model to study the mechanisms governing muscle cachexia under various clinical conditions. Although, a large number of studies have investigated EIMD and its associated inflammatory response, several aspects of skeletal muscles responses remain unclear. In the first section of this article, the mechanisms of EIMD are reviewed in an attempt to follow the events that result in functional and structural alterations of skeletal muscle. In the second section, the inflammatory response associated with EIMD is presented with emphasis in leukocyte accumulation through mechanisms that are largely coordinated by pro- and anti-inflammatory cytokines released either by injured muscle itself or other cells. The practical applications of EIMD and the subsequent inflammatory response are discussed with respect to athletic performance. Specifically, the mechanisms leading to performance deterioration and development of muscle soreness are discussed. Emphasis is given to the factors affecting individual responses to EIMD and the resulting interindividual variability to this phenomenon. © 2016 Fatouros and Jamurtas

Exercise and Type II Diabetes Mellitus: A Brief Guide for Exercise Professionals

Exercise is an effective tool for managing and treating type II diabetes (T2DM) and may be a useful component of a diabetes management program. Both short- or long-term exercise interventions can improve physical fitness, metabolic health, and cardiovascular function in individuals with poor glycemic control. Incorporating aerobic and resistance exercise as part of a comprehensive diabetes management plan can play a vital role in the fight against this chronic metabolic disease. Progression and individualized exercise programming are critical for an effective and enjoyable exercise experience in a gym setting. With respect to safety, exercise professionals should be aware of special considerations and potential complications persons with T2DM can experience when exercising. © 2022 Lippincott Williams and Wilkins. All rights reserved

High-Intensity Interval Training in Metabolic Diseases: Physiological Adaptations

Apply It! From this article, the reader should understand the following concepts: • The impact of high-intensity interval training on physiological and psychological responses among individuals with metabolic diseases. • A strategy for prescribing high-intensity interval training protocols in adults with obesity, type 2 diabetes, dyslipidemia, and metabolic syndrome. © Lippincott Williams & Wilkins

Glycemic Index, Food Exchange Values, and Exercise Performance

This chapter examines how dietary glycemic index (GI) and glycemic load affect health and exercise performance. Current available evidence suggests that there is an association between GI and various types of cancer, cardiovascular, and metabolic diseases. GI has also gained interest in the field of sports nutrition over the last years. It seems that the intensity of the glycemic and insulinemic responses in the postprandial period and during exercise is considered as a main contributor to enhanced performance. It is argued that low-GI preexercise meals may enhance athletic performance with the results being contradictory. In addition, to that, the ingestion of carbohydrates during exercise after a preexercise meal with different GIs has not been adequately investigated. Food exchanges that can simplify meal planning and ensure a consistent, nutritionally balanced diet, are also discussed. © 2019 Elsevier Inc. All rights reserved

National survey of fitness trends in Greece for 2021

The objective of this study was to identify the most important health/fitness trends while examining the impact of various demographics of respondents on the top trends for the first time in Greece. An online survey was sent to 3,487 professionals who worked in the health/fitness sector using the methodology of similar regional and worldwide studies extensively conducted by the American College of Sports Medicine (ACSM). A total of 542 responses were collected with a response rate of 15.5%. The ten most important trends were personal training, exercise is medicine, high-intensity interval training, small group training, and functional fitness, body weight training, exercise for weight loss, circuit training, strength training with free weights, and fitness programs for older adults. Health-related trends appear to be popular while technology-and mind/body-related trends seem not to be very attractive. Traditional exercise modes are still attractive and relevant, but specialized group training approaches are currently experiencing low popularity. Results also showed meaningful sex differences for 68% of the examined trends where female respondents reported higher scores. The main findings of this study are in line with those recently reported in the ACSM’s European survey even though similar research design and data analysis are limited internationally. © 2020 by authors, all rights reserved

Unilateral Plyometric Training is Superior to Volume-Matched Bilateral Training for Improving Strength, Speed and Power of Lower Limbs in Preadolescent Soccer Athletes

This study compared the effects of unilateral and bilateral plyometric training on strength, sprint performance and lower limb power. Sixty-eight preadolescent soccer athletes were randomly assigned to a unilateral plyometric training group (n=23), a bilateral plyometric training group (n=23) and a control group (n=22). Both plyometric training groups trained with equal volumes of unilateral or bilateral exercises for 15 minutes in each session, at which time the control group performed soccer-specific drills. Plyometric exercises were executed twice weekly for 10 weeks during the competitive season. The following tests were performed before and after the intervention: single-leg and double-leg countermovement jump, squat jump, horizontal jumps in different directions, maximal isometric strength of quadriceps and hamstrings, sprint performance, agility and balance. Unilateral plyometric training resulted in greater improvements compared to the control group in the following variables: hamstrings strength (ES: 0.91, p=0.037), 5m sprint time (ES: 0.93, p=0.004), single-leg countermovement jump (ES: 0.90, p=0.006), single- and double-leg squat jump (ES: 0.87, p=0.030 and ES: 0.73, p=0.067, respectively) and single-leg hop performance (ES: 1.01, p=0.004). The only tests where there was an improvement of BPT compared with the CG were the single-leg and double leg SJ (ES: 0.76, p=0.026; ES: 0.70, p=0.050). Quadriceps strength, side hop test, double-leg horizontal jump test, flamingo balance test and modified agility T-test were equally improved in all three groups (p<0.001). In conclusion, unilateral lower-limb plyometric training is more effective in increasing muscle strength and power in preadolescent soccer players when compared to bilateral training or soccer training alone. © 2020 Vasileios Drouzas, Christos Katsikas, Andreas Zafeiridis, Athanasios Z. Jamurtas, Gregory C. Bogdanis, published by Sciendo 2020

Improving hydration in elite male footballers during a national team training camp – an observational case study

[Purpose] The purpose of this study was to (i) assess hydration levels in elite male football players during a national team training camp before and during qualifying matches, (ii) evaluate the effect of coaching strategies for hydration based on feedback from hydration monitoring, and (iii) assess possible relationships between hydration status and training load or wellness markers. [Methods] Thirty-one male players (age 27±4 yrs; height 185±6 cm; weight 82.9±6.7 kg; body fat 10.4±2.3%) representing a national team from the Union of European Football Associations (UEFA) participated. The players were studied during three different national team training camps related to the UEFA Nations League tournament. Urine specific gravity (USG) was measured to assess hydration status. During all camps, the players were actively coached on improving strategies for hydration and given individual feedback on their test results. The training load was measured using GPS technology, and wellness questionnaires were completed. [Results] USG decreased progressively and significantly (p&lt;0.005) during camp 1 and hydration status improved over the three camps, with fewer dehydrated and more well-hydrated players identified during the last part of camp 3. Significantly (p&lt;0.05) higher USG values were observed 2 days prior to a match (MD-2) than on match day (MD); consequently, 52% of the players were dehydrated on MD-2 and only 6% on MD. No correlations were observed between hydration status and training load or wellness markers. [Conclusion] Dehydration is a challenge in elite male football, but continuous monitoring of hydration status and coaching on hydration strategies can lead to major improvements and reduce the degree of dehydration. ©2021 Magni Mohr et al. ©2021 The Korean Society for Exercise Nutrition