1 research outputs found
Concise Copper-Catalyzed Synthesis of Tricyclic Biaryl Ether-Linked Aza-Heterocyclic Ring Systems
A new method for the synthesis of tricyclic biaryl ether-linked
ring systems incorporating seven-, eight-, and nine-membered ring
amines is presented. In the presence of catalytic quantities of copper(I),
readily accessible acyclic precursors undergo an intramolecular carbon–oxygen
bond-forming reaction facilitated by a “templating”
chelating nitrogen atom. The methodology displays a broad substrate
scope, is practical, and generates rare and biologically interesting
tricyclic heteroaromatic products that are difficult to access by
other means