Status of approved protocols for Decullier 2006 study [22].

<p>Status of approved protocols for Decullier 2006 study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066844#pone.0066844-Decullier2" target="_blank">[22]</a>.</p

Comparisons of primary outcome stated in protocol and in publication.

<p>NA Not Applicable.</p>*<p>The study did not investigate this.</p>1<p>Gives results for trials with discrepancies for ≥1 primary outcome.</p>2<p>Results obtained from 248 of the completed studies.</p

Status of approved protocols for Turer 2007 study [28].

<p>Status of approved protocols for Turer 2007 study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066844#pone.0066844-Turer1" target="_blank">[28]</a>.</p

Status of approved protocols for Chan 2004a study [18].

<p>Status of approved protocols for Chan 2004a study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066844#pone.0066844-Chan2" target="_blank">[18]</a>.</p

Status of approved protocols for Ioannidis 1998 study [5].

<p>Status of approved protocols for Ioannidis 1998 study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066844#pone.0066844-Ioannidis1" target="_blank">[5]</a>.</p

Status of approved protocols for Ghersi 2006 study [25].

<p>Status of approved protocols for Ghersi 2006 study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066844#pone.0066844-Ghersi1" target="_blank">[25]</a>.</p

Status of approved protocols for Chan 2004b study [17].

<p>Status of approved protocols for Chan 2004b study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066844#pone.0066844-Chan1" target="_blank">[17]</a>.</p

PRISMA flow diagram.

<p>PRISMA flow diagram.</p