Galactic Scale Feedback Observed in the 3C 298 Quasar Host Galaxy

We present high angular resolution multi-wavelength data of the 3C 298 radio-loud quasar host galaxy (z=1.439) taken using the W.M. Keck Observatory OSIRIS integral field spectrograph with adaptive optics, Atacama Large Millimeter/submillimeter Array (ALMA), Hubble Space Telescope (HST) WFC3, and the Very Large Array (VLA). Extended emission is detected in the rest-frame optical nebular emission lines H$\beta$, [OIII], H$\alpha$, [NII], and [SII], as well as molecular lines CO (J=3-2) and (J=5-4). Along the path of 3C 298's relativistic jets we detect conical outflows of ionized gas with velocities up to 1700 km s$^{-1}$ and outflow rate of 450-1500 M$_\odot$yr$^{-1}$. Near the spatial center of the conical outflow, CO (J=3-2) emission shows a molecular gas disc with a total molecular mass ($\rm M_{H_{2}}$) of 6.6$\pm0.36\times10^{9}$M$_{\odot}$. On the molecular disc's blueshifted side we observe a molecular outflow with a rate of 2300 M$_\odot$yr$^{-1}$ and depletion time scale of 3 Myr. We detect no narrow H$\alpha$ emission in the outflow regions, suggesting a limit on star formation of 0.3 M$_\odot$yr$^{-1}$kpc$^{-2}$. Quasar driven winds are evacuating the molecular gas reservoir thereby directly impacting star formation in the host galaxy. The observed mass of the supermassive black hole is $10^{9.37-9.56}$M$_{\odot}$ and we determine a dynamical bulge mass of 1-1.7$\rm\times10^{10}\frac{R}{1.6 kpc}$ M$_{\odot}$. The bulge mass of 3C 298 resides 2-2.5 orders of magnitude below the expected value from the local M$\rm_{bulge}-M_{BH}$ relationship. A second galactic disc observed in nebular emission is offset from the quasar by 9 kpc suggesting the system is an intermediate stage merger. These results show that galactic scale negative feedback is occurring early in the merger phase of 3C 298, well before the coalescence of the galactic nuclei and assembly on the local relationship.Comment: 23 pages, 11 figures, 4 tables, Accepted for publication in the Astrophysical Journa

Direct estimation of cause-specific mortality fractions from verbal autopsies: multisite validation study using clinical diagnostic gold standards

<p>Abstract</p> <p>Background</p> <p>Verbal autopsy (VA) is used to estimate the causes of death in areas with incomplete vital registration systems. The King and Lu method (KL) for direct estimation of cause-specific mortality fractions (CSMFs) from VA studies is an analysis technique that estimates CSMFs in a population without predicting individual-level cause of death as an intermediate step. In previous studies, KL has shown promise as an alternative to physician-certified verbal autopsy (PCVA). However, it has previously been impossible to validate KL with a large dataset of VAs for which the underlying cause of death is known to meet rigorous clinical diagnostic criteria.</p> <p>Methods</p> <p>We applied the KL method to adult, child, and neonatal VA datasets from the Population Health Metrics Research Consortium gold standard verbal autopsy validation study, a multisite sample of 12,542 VAs where gold standard cause of death was established using strict clinical diagnostic criteria. To emulate real-world populations with varying CSMFs, we evaluated the KL estimations for 500 different test datasets of varying cause distribution. We assessed the quality of these estimates in terms of CSMF accuracy as well as linear regression and compared this with the results of PCVA.</p> <p>Results</p> <p>KL performance is similar to PCVA in terms of CSMF accuracy, attaining values of 0.669, 0.698, and 0.795 for adult, child, and neonatal age groups, respectively, when health care experience (HCE) items were included. We found that the length of the cause list has a dramatic effect on KL estimation quality, with CSMF accuracy decreasing substantially as the length of the cause list increases. We found that KL is not reliant on HCE the way PCVA is, and without HCE, KL outperforms PCVA for all age groups.</p> <p>Conclusions</p> <p>Like all computer methods for VA analysis, KL is faster and cheaper than PCVA. Since it is a direct estimation technique, though, it does not produce individual-level predictions. KL estimates are of similar quality to PCVA and slightly better in most cases. Compared to other recently developed methods, however, KL would only be the preferred technique when the cause list is short and individual-level predictions are not needed.</p

Sheep Updates 2014

This session covers nine papers from different authors: Genetic Research: A brave new world of opportunities 1. China\u27s Appetite - The implications for WA, James Kynge, Chairman, FT Confidential Research, Emerging Markets Editor, Financial Times, London. 2. The genetics warm-up - the secret language of genetic research and its impacts on WA\u27s sheep flock, Professor David Lindsay, University of Western Australia, Perth WA The strength of genetic data: is it really valuable? 3. Genetic research in Western Australia - What have the compromises in production been? Johan Greeff, Senior Geneticist, Department of Agriculture and Food Western Australia 4. Show me the money - the case for genetic selection, John Young, Farming Systems Analysis Service, Kojonup WA 5. Using ASBVs and Indexes, Luke Stephen, Project Officer MERINOSELECT, Sheep Genetics, Armidale NSW Concurrent 6. New traits for the sheep industry, Dr Graham Gardner, Associate Professor in Biochemistry, Toxicology and Nutrition at Murdoch University, WA 7. Genomics and DNA testing: new tools for ram breeders to accelerate gain Dr Stephen Lee, School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy Campus, SA 8. Producer case study: using genetic data and tools to make a better product, Bindi Murray, Livestock Manager, Kunmallup Pastoral Co, Woodanilling WA. 9. New Sheep CRC - vision for future genetic progress, James Rowe, CEO, Sheep CRC, UNE, Armidale NS

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons.

Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications. Prominent uses include as intracellular antibodies or intrabodies to bind and deliver cargo to specific proteins and/or subcellular sites within cells, and as nanoscale immunolabels for enhanced tissue penetration and improved spatial imaging resolution. Here, we report the generation and validation of nAbs against a set of proteins prominently expressed at specific subcellular sites in mammalian brain neurons. We describe a novel hierarchical validation pipeline to systematically evaluate nAbs isolated by phage display for effective and specific use as intrabodies and immunolabels in mammalian cells including brain neurons. These nAbs form part of a robust toolbox for targeting proteins with distinct and highly spatially-restricted subcellular localization in mammalian brain neurons, allowing for visualization and/or modulation of structure and function at those sites

IROCKS: Spatially Resolved Kinematics of z ~ 1 Star-forming Galaxies

We present results from the Intermediate Redshift OSIRIS Chemo-Kinematic Survey (IROCKS) for sixteen z ~ 1 and one z ~ 1.4 star-forming galaxies. All galaxies were observed with OSIRIS with the laser guide star adaptive optics system at Keck Observatory. We use rest-frame nebular Hα emission lines to trace morphologies and kinematics of ionized gas in star-forming galaxies on sub-kiloparsec physical scales. We observe elevated velocity dispersions (σ ≳ 50 km s^(−1)) seen in z > 1.5 galaxies persist at z ~ 1 in the integrated galaxies. Using an inclined disk model and the ratio of v/σ, we find that 1/3 of the z ~ 1 sample are disk candidates while the other 2/3 of the sample are dominated by merger-like and irregular sources. We find that including extra attenuation toward H ii regions derived from stellar population synthesis modeling brings star formation rates (SFRs) using Hα and stellar population fit into a better agreement. We explore the properties of the compact Hα sub-component, or "clump," at z ~ 1 and find that they follow a similar size–luminosity relation as local H ii regions but are scaled-up by an order of magnitude with higher luminosities and sizes. Comparing the z ~ 1 clumps to other high-redshift clump studies, we determine that the clump SFR surface density evolves as a function of redshift. This suggests clump formation is directly related to the gas fraction in these systems and may support disk fragmentation as their formation mechanism since gas fraction scales with redshift

Bleaching of lignocellulosic material with in-situ-generated dioxirane

A chemical pulp which contains reactants capable of generating dioxirane within the pulp is produced in a process which comprises mixing a pulp with reactants comprising a carbonyl compound, preferably acetone, and an oxygen donor, preferably monoperoxysulfate, in proportions which produce a water-soluble dioxirane having a molecular diameter of less than 140 angstrom units. Such a pulp bleaching process which employs dioxirane as a bleaching agent is rendered environmentally and economically acceptable by recycling the reactants employed to produce the dioxirane. For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office\u27s free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.htmlhttps://irl.umsl.edu/patents/1005/thumbnail.jp