Trabecular bone chemical composition using FTIRI.

<p>A) Level of mineralization as a proportion of the inorganic to organic matrix, in the trabecular bone of irradiated mice compared to control at 2d, 10d, and 8w following irradiation. *p<0.05 compared to age-matched control. B) A typical FTIRI heat map of the level of mineralization in a control (left) and an irradiated (right) trabecular strut at 2d. Increased intensity corresponds to increased degree of mineralization.</p

Mechanical properties of trabecular bone at 2d, 10d, and 8w following irradiation.

<p>As early as 2d following irradiation, alterations in the trabecular bone led to an increase in hardness and elastic modulus which was no longer present at 10d. *p<0.05 compared to control.</p

Light microscope image of mouse tibiae stained with Modified Wright Giemsa at 10d following irradiation.

<p>Image on the left is a control, and on the right is an irradiated mouse. The empty spaces in the marrow of the irradiated bone correspond to the rapid infiltration of fat cells, a consequence of which is that there is less space for immune cells to occupy the bone marrow space. Scale bar represents 1 mm.</p

Trabecular and cortical bone parameters in the tibiae of irradiated mice compared to the age-matched control at 2d, 10d, and 8w.

<p>By 10d following irradiation, although there was a deficit to the trabecular bone architecture compared to non-irradiated control, no significant differences were apparent in the cortical bone between the irradiated mice and the age-matched control.</p