Row Width Effects on Corn Yield at Varying Plant Densities

The majority of corn acres in Iowa are planted in “conventional” 30-inch row widths, with some farmers choosing to stay with the 38-inch row system. Questions often arise on the magnitude of yield penalty, whether there really is a yield penalty, or if there is actually a benefit to wider row corn in specific situations with today’s elite hybrids. Recommendations are difficult because current data do not exist. There also is growing interest in narrower row corn (20-inch) and any economical or environmental benefits associated with this practice. These two questions have created a need for more research involving modern hybrids and management practices. The objectives of this study were to (1) identify any row width benefits and (2) determine the optimum planting population for each row width. In addition to this site in 2000, this research was conducted at two other university research farms

A cautionary note on the appropriateness of using a linkage resource for an association study

BACKGROUND: Utilizing a linkage resource for association analysis requires consideration both of the marker data used and correlations among relatives in pedigrees. We previously developed a method for association testing in pedigrees. We applied our method to 50 replicates of microsatellite data surrounding five genes involved in high-density lipoprotein (HDL) in the Genetic Analysis Workshop 13 (GAW13) simulated data and examined association with HDL as well as linkage disequilibrium (LD) between markers. RESULTS: Although no association was intentionally simulated, we found significant evidence of weak LD between microsatellite markers (flanking/~5 cM from the genes), in some but not all replicates. This level of LD compared well to that observed in the real GAW13 Framingham data. Only one region had sufficient replicates to assess power, and this was low (12.5–20.8%). More power was attained using all individuals and accounting for relationships, compared with one independent individual/pedigree, although this was not significant due to small sample sizes. Not accounting for relatedness inflated statistical significance (p < 0.0001). CONCLUSION: A correction for dependence is necessary in association studies to avoid an inflation of significance probabilities. Our results further illustrate that use of microsatellite marker data is not an effective approach for association testing

Increased risk for other cancers in individuals with Ewing sarcoma and their relatives.

BackgroundThere are few reports of the association of other cancers with Ewing sarcoma in patients and their relatives. We use a resource combining statewide genealogy and cancer reporting to provide unbiased risks.MethodsUsing a combined genealogy of 2.3 million Utah individuals and the Utah Cancer Registry (UCR), relative risks (RRs) for cancers of other sites were estimated in 143 Ewing sarcoma patients using a Cox proportional hazards model with matched controls; however, risks in relatives were estimated using internal cohort-specific cancer rates in first-, second-, and third-degree relatives.ResultsCancers of three sites (breast, brain, complex genotype/karyotype sarcoma) were observed in excess in Ewing sarcoma patients. No Ewing sarcoma patients were identified among first-, second-, or third-degree relatives of Ewing sarcoma patients. Significantly increased risk for brain, lung/bronchus, female genital, and prostate cancer was observed in first-degree relatives. Significantly increased risks were observed in second-degree relatives for breast cancer, nonmelanoma eye cancer, malignant peripheral nerve sheath cancer, non-Hodgkin lymphoma, and translocation sarcomas. Significantly increased risks for stomach cancer, prostate cancer, and acute lymphocytic leukemia were observed in third-degree relatives.ConclusionsThis analysis of risk for cancer among Ewing sarcoma patients and their relatives indicates evidence for some increased cancer predisposition in this population which can be used to individualize consideration of potential treatment of patients and screening of patients and relatives

Effects of Grazing Crop Residues of bt-Corn Hybrids on Performance of Pregnant Beef Cows

To determine the effects of grazing crop residues from bt-corn hybrids on performance of pregnant beef cows, one non bt-corn hybrid (Pioneer 3489) and three bt-corn hybrids (Pioneer 34RO7 and Novartis NX6236 with the Yieldgard event and Novartis N64Z4 with the Knockout event) were planted in duplicate 7.1-acre fields in 1998 and 1999. Thirty Angus x Charolais x Simmental cows in midgestation were allotted amongst two drylots or the eight crop residue fields to strip-graze for 126 days. Cow body condition scores were visually estimated biweekly and alfalfa-grass hay was supplemented to maintain a mean body condition score of 5 on a 9-point scale. Corn stalks and ear shanks from Pioneer 3489 corn had a higher (P\u3c.05) infestation of corn borers than did any of the bt-corn hybrids. Mean yields of harvested grain, dropped ears or grain, or crop residue dry matter (DM) or organic matter (OM) over the two years were not significantly affected by corn hybrid, but values for bt-corn hybrids were not equivalent to the non bt-corn hybrid. At grazing initiation, crop residues from Novartis NX6236 and N64Z4 had higher (P\u3c.05) concentrations of in vitro digestible organic matter (IVOMD) and lower (P\u3c.05) concentrations of acid detergent fiber (ADF) and acid detergent lignin (ADL) than Pioneer 3489 or Pioneer 34RO7. Rates of change in the concentrations of IVOMD, neutral detergent fiber (NDF), ADF, ADL and crude protein (CP) over winter were not significantly affected by corn hybrid, but rates for bt-corn hybrids were not equivalent to non bt-corn hybrids. Forage selected during feeding by fistulated steers did not differ in IVOMD concentrations between winter feeding systems or NDF, ADF, CP or acid detergent insoluble nitrogen (ADIN) concentrations between corn hybrids. Intakes of forage digestible DM, NDF and ADF did not differ between winter feeding systems, but were not equivalent to the non bt-corn hybrid. Mean amounts of hay required to maintain body condition score of cows maintained in a drylot were greater than cows grazing crop residues (3199 vs 825 lb DM/cow), but did not differ between corn hybrids

A data-driven classification of outcome behaviors in those who cause concern to British public figures

Fixated individuals pose a significant threat to public figures. Previous research compares individuals labeled ‘approachers’ to those labeled ‘communicators.’ Typically, such studies compare a number of risk factors among the two groups to identify significant differences. This has impactful implications for the threat assessment and management of the pathologically fixated. The present study builds upon this established body of work by considering if more nuance can be disaggregated from a universe of cases referred to the Fixated Threat Assessment Center (FTAC). FTAC is a joint police and mental health unit in the U.K. which applies a public health approach to managing the pathologically fixated. The present study takes a deductive approach to detect profiles of cases from the data. First, we use cluster analysis to detect unmeasured subgroups of concerning behavior in the case files of 2,118 referrals to FTAC. We identify 5 patterns of concerning behavior: incoherent offline communicators, incoherent online communicators, angry/abusive communicators, concerning approachers, and problematic approachers. Second, we examine the rate of diagnosed mental disorder, the nature of concerns evoked, and case management actions taken among each of the five profiles identified. We conclude by highlighting how our results could inform triaging large volumes of cases, the allocation of limited resources, and more generally, how the success of the FTAC model has relevance across the management of grievance-fueled violence in general. (PsycInfo Database Record (c) 2021 APA, all rights reserved

Predictors of varying levels of risks posed by fixated individuals to British public figures

Concerning approaches and communications to the Royal Family and other British public figures are relatively numerous. This paper examines over 2000 such cases logged over a three-year period in the United Kingdom. Using police and health data, the paper conducts a series of bivariate and multivariate analyses to demonstrate the predictors of what types of risk are posed by an individual case (e.g., communicate only, approach, security breach). The results showed that (a) the rates of serious mental disorders are higher among this sample than the general population base rate, (b) approachers were significantly more likely than communicators to suffer from serious mental disorders, (c) approachers were significantly more likely than communicators to have a history of substance use and abuse problems, (d) approachers were significantly more likely than communicators to have a history of violent behavior against property and persons, and (e) the motivations of approachers and communicators significantly differ. The paper concludes with a consideration of the implications for threat assessment and management

No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees

<p>Abstract</p> <p>Background</p> <p>Germline mutations in the <it>BRCA2 </it>gene have been suggested to account for about 5% of familial prostate cancer; mutations have been reported in 2% of early onset (i.e., ≤ 55 years) prostate cancer cases and a segregating founder mutation has been identified in Iceland (999del5). However, the role of <it>BRCA2 </it>in high risk prostate cancer pedigrees remains unclear.</p> <p>Findings</p> <p>We examined the potential involvement of <it>BRCA2 </it>in a set offive high-risk prostate cancer pedigrees in which all prostate cases were no more distantly related than two meioses from another case, and the resulting cluster contained at least four prostate cancer cases. We selected these five pedigrees from a larger dataset of 59 high-risk prostate cancer pedigrees analyzed in a genome-wide linkage screen. Selected pedigrees showed at least nominal linkage evidence to the <it>BRCA2 </it>region on chromosome 13q. We mutation screened all coding regions and intron/exon boundaries of the <it>BRCA2 </it>gene in the youngest prostate cancer case who carried the linked 13q segregating haplotype, as well as in a distantly related haplotype carrier to confirm any segregation. We observed no known protein truncating <it>BRCA2 </it>deleterious mutations. We identified one non-segregating <it>BRCA2 </it>variant of uncertain significance, one non-segregating intronic variant not previously reported, and a number of polymorphisms.</p> <p>Conclusion</p> <p>In this set of high-risk prostate cancer pedigrees with at least nominal linkage evidence to <it>BRCA2</it>, we saw no evidence for segregating <it>BRCA2 </it>protein truncating mutations in heritable prostate cancer.</p