Lab Experiments are a Major Source of Knowledge in the Social Sciences

Laboratory experiments are a widely used methodology for advancing causal knowledge in the physical and life sciences. With the exception of psychology, the adoption of laboratory experiments has been much slower in the social sciences, although during the last two decades, the use of lab experiments has accelerated. Nonetheless, there remains considerable resistance among social scientists who argue that lab experiments lack ‘realism’ and ‘generalizability’. In this article we discuss the advantages and limitations of laboratory social science experiments by comparing them to research based on non-experimental data and to field experiments. We argue that many recent objections against lab experiments are misguided and that even more lab experiments should be conducted.laboratory experiments, field experiments, controlled variation

Lab Experiments are a Major Source of Knowledge in the Social Sciences

Laboratory experiments are a widely used methodology for advancing causal knowledge in the physical and life sciences. With the exception of psychology, the adoption of laboratory experiments has been much slower in the social sciences, although during the last two decades, the use of lab experiments has accelerated. Nonetheless, there remains considerable resistance among social scientists who argue that lab experiments lack “realism” and “generalizability”. In this article we discuss the advantages and limitations of laboratory social science experiments by comparing them to research based on non-experimental data and to field experiments. We argue that many recent objections against lab experiments are misguided and that even more lab experiments should be conducted.laboratory experiments, field experiments, controlled variation

Lab Experiments Are a Major Source of Knowledge in the Social Sciences

Laboratory experiments are a widely used methodology for advancing causal knowledge in the physical and life sciences. With the exception of psychology, the adoption of laboratory experiments has been much slower in the social sciences, although during the last two decades, the use of lab experiments has accelerated. Nonetheless, there remains considerable resistance among social scientists who argue that lab experiments lack "realism" and "generalizability". In this article we discuss the advantages and limitations of laboratory social science experiments by comparing them to research based on non-experimental data and to field experiments. We argue that many recent objections against lab experiments are misguided and that even more lab experiments should be conducted.laboratory experiments, field experiments, controlled variation

MESA and NuGrid Simulations of Classical Nova Outbursts and Nucleosynthesis

Classical novae are the results of surface thermonuclear explosions of hydrogen accreted by white dwarfs (WDs) from their low-mass main-sequence or red-giant binary companions. Chemical composition analysis of their ejecta shows that nova outbursts occur on both carbon-oxygen (CO) and more massive oxygen-neon (ONe) WDs, and that there is cross-boundary mixing between the accreted envelope and underlying WD. We demonstrate that the state-of-the-art stellar evolution code MESA and post-processing nucleosynthesis tools of NuGrid can successfully be used for modeling of CO and ONe nova outbursts and nucleosynthesis. The convective boundary mixing (CBM) in our 1D numerical simulations is implemented using a diffusion coefficient that is exponentially decreasing with a distance below the bottom of the convective envelope. We show that this prescription produces maximum temperature evolution profiles and nucleosynthesis yields in good agreement with those obtained using the commonly adopted 1D nova model in which the CBM is mimicked by assuming that the accreted envelope has been pre-mixed with WD's material. In a previous paper, we have found that 3He can be produced in situ in solar-composition envelopes accreted with slow rates (dM/dt < 1e-10 M_sun/yr) by cold (T_WD < 1d7 K) CO WDs, and that convection is triggered by 3He burning before the nova outburst in this case. Here, we confirm this result for ONe novae. Additionally, we find that the interplay between the 3He production and destruction in the solar-composition envelope accreted with an intermediate rate, e.g. dM/dt = 1e-10 M_sun/yr, by the 1.15 M_sun ONe WD with a relatively high initial central temperature, e.g. T_WD = 15e6 K, leads to the formation of a thick radiative buffer zone that separates the bottom of the convective envelope from the WD surface.Comment: 6 pages, 4 figures, STELLA NOVAE: FUTURE AND PAST DECADES Conference Proceedings, Submitted to ASP Conference Serie

The inspiratory capacity/total lung capacity ratio as a predictor of survival in an emphysematous phenotype of chronic obstructive pulmonary disease.

BackgroundForced expiratory volume in 1 second (FEV1) grades severity of COPD and predicts survival. We hypothesize that the inspiratory capacity/total lung capacity (IC/TLC) ratio, a sensitive measure of static lung hyperinflation, may have a significant association with survival in an emphysematous phenotype of COPD.ObjectivesTo access the association between IC/TLC and survival in an emphysematous phenotype of COPD.MethodsWe performed a retrospective analysis of a large pulmonary function (PF) database with 39,050 entries, from April 1978 to October 2009. Emphysematous COPD was defined as reduced FEV1/forced vital capacity (FVC), increased TLC, and reduced diffusing capacity of the lungs for carbon monoxide (DLCO; beyond 95% confidence intervals [CIs]). We evaluated the association between survival in emphysematous COPD patients and the IC/TLC ratio evaluated both as dichotomous (≤25% vs &gt;25%) and continuous predictors. Five hundred and ninety-six patients had reported death dates.ResultsUnivariate analysis revealed that IC/TLC ≤25% was a significant predictor of death (hazard ratio [HR]: 2.39, P&lt;0.0001). Median survivals were respectively 4.3 (95% CI: 3.8-4.9) and 11.9 years (95% CI: 10.3-13.2). Multivariable analysis revealed age (HR: 1.19, 95% CI: 1.14-1.24), female sex (HR: 0.69, 95% CI: 0.60-0.83), and IC/TLC ≤25% (HR: 1.69, 95% CI: 1.34-2.13) were related to the risk of death. Univariate analysis showed that continuous IC/TLC was associated with death, with an HR of 1.66 (95% CI: 1.52-1.81) for a 10% decrease in IC/TLC.ConclusionAdjusting for age and sex, IC/TLC ≤25% is related to increased risk of death, and IC/TLC as a continuum, is a significant predictor of mortality in emphysematous COPD patients