2 research outputs found
Observing the Nucleation Phase of Atomic Layer Deposition In Situ
We present in situ topographical observations of film
growth during
the initial cycles of atomic layer deposition (ALD) using scanning
tunneling microscopy (STM). We present cycle-by-cycle STM topographs
of zinc sulfide films during ALD on Au(111) surfaces, tracking individual
grains, 5 nm in diameter, as they grow over tens of cycles. We find
that grain morphology is temperature-dependent and grain size increases
with deposition temperature from 100 to 160 °C
Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors
A novel thiazolopyrimidinone series of PI3K-beta selective inhibitors
has been identified. This chemotype has provided an excellent tool
compound, <b>18</b>, that showed potent growth inhibition in
the PTEN-deficient breast cancer cell line MDA-MB-468 under anchorage-independent
conditions, and it also demonstrated pharmacodynamic effects and efficacy
in a PTEN-deficient prostate cancer PC-3 xenograft mouse model