Interior MRI reconstruction of a cardiac image phantom.

<p>The top row (a)–(c) is from fully sampled data (100%), and the bottom row (d)–(f) is from randomly under-sampled data (25%) along the phase-encoding direction. The first column (a) and (d) is by the inverse fast Fourier transform (IFFT), the second column (b) and (e) by the TV minimization from global MR data, and the third column (c) and (f) by the TV minimization from interior MRI data.</p

State-of-the-art tri-modality fusion systems.

<p>(a) The AnyScan system for clinical PET-SPECT-CT, and (b) the Albira system for preclinical PET-SPECT-CT ((a) and (b) from <a href="http://www.mediso.de/anyscan-sc.html" target="_blank">http://www.mediso.de/anyscan-sc.html</a> and <a href="http://www.cmi-marketing.com/7modalities" target="_blank">http://www.cmi-marketing.com/7modalities</a> respectively, with the legends added by the authors of this article).</p

Generation of a locally homogeneous magnetic field.

<p>(a) The magnetic flux from four permanent blocks. The square area (20×20 cm²) represents a region of interest (ROI) where the magnetic flux ranges from 0.208 to 0.211Tesla; (b) and (c) the magnetic flux plots along the x- and y-axes respectively. Each magnetic block is of 40×40×20 cm³, with a gap of 2 cm between two parts of each magnetic pole.</p

Interior SPECT reconstruction of a cardiac phantom.

<p>(a) An original SPECT ROI image of 128×128 pixels covering an area of 12.8×12.8 cm², (b) an interior reconstruction using the HOT minimization algorithm with the attenuation background µ₀ = 0.15 after 40 iterations, (c) and (d) the pseudo-color counterparts of (a) and (b) respectively. (e) and (f) The profiles along the horizontal and vertical white lines respectively in (a) and (b), where the thick lines on the horizontal axes indicate the ROI. The display window for (a) and (b) is [0, 1.0] in a normalized unit.</p

Unified CT-MRI reconstruction using inter-modality coherence.

<p>An MRI-CT head scan consisted of MR T1 (the 1^st column), T2 (the 2^nd column), proton density images (the 3^rd column), and a CT image (the 4^th column). The top row shows the phantom images, the middle row the images separately reconstructed using the conventional FFT or FBP method, and the bottom row the images simultaneously reconstructed in the unified rank-sparsity decomposition framework.</p

Advanced Multimodality Image Guided Operating (AMIGO) Suite unveiled on May 4, 2011.

<p>It is an integrated surgical and interventional environment as the translational test bed of the National Center for Image-Guided Therapy (NCIGT) at the Brigham and Women’s Hospital (BWH) and Harvard Medical School (from <a href="http://www.ncigt.org/pages/AMIGO" target="_blank">http://www.ncigt.org/pages/AMIGO</a>, with the legends added by the authors of this paper).</p

Ring-shaped design for omni-tomography.

<p>(a) A 3D rendering of the top-level design, (b) a partial rendering, (c) an in-plane view, and (d) a through-plane view. There are two static rings and one rotating ring for omni-tomography. While the red C-arm is a permanent magnet and the yellow outer ring contains PET crystals, the blue ring supports a CT tube, a CT detector and a pair of SPECT camera. The blue CT-SPECT ring is on a green slip ring (like a large ball bearing) as the interface for power and data. The CT-SPECT ring, the slip-ring, and the PET ring all go through the magnetic poles.</p

Interior CT reconstruction of a cardiac region from a clinical patient dataset collected on a GE Discovery CT750 HD scanner.

<p>(a) The reference image reconstructed from global projections using the conventional filtered backprojection (FBP) method, (b) a magnified interior cardiac region, (c) and (d) the interior reconstructions from truncated local projections after 10 and 20 iterations, respectively. (e) and (f) The profiles along the horizontal and vertical white lines respectively in (b)–(d), where the thick lines on the horizontal axes indicate the ROI. The display window for (a)–(d) is [−1000, 1000] HU.</p

Double-magnetic-donut-based design for omni-tomography.

<p>The pair of green magnetic rings is arranged similar to that in the Fonar UPRIGHT Multi-Position MRI (<a href="http://www.fonar.com/standup.htm" target="_blank">http://www.fonar.com/standup.htm</a>) but with a decreased spatial extent of a homogeneous magnetic background field and thus an increased gantry room for interior CT, interior SPECT, and other modalities. This design is scalable according to preferred sizes of animals or humans.</p

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in diverse tumors, and high expression levels have been linked to poor prognosis in breast cancer patients. TRIM24 contains a PHD/bromodomain offering the opportunity to develop protein interaction inhibitors that target this protein interaction module. Here we identified potent acetyl-lysine mimetic benzimidazolones TRIM24 bromodomain inhibitors. The best compound of this series is a selective BRPF1B/TRIM24 dual inhibitor that bound with a <i>K</i>_D of 137 and 222 nM, respectively, but exerted good selectivity over other bromodomains. Cellular activity of the inhibitor was demonstrated using FRAP assays as well as cell viability data