Aspects of management options for pasture-based dairy production stocked at two cows per hectare

End of project reportWhite clover in association with Rhizobium bacteria have the capacity to fix or convent atmospheric N into plant available N. This can make a considerable contribution to sward productivity. One of the objectives of this experiment was to determine the upper carrying capacity of grass-white clover swards receiving 90 kg fertilizer N/ha. A second objective was to examine the impact of grass-clover swards on mineral-N in the soil and losses of nitrate-N from soil to drainage water during the winter. This experiment was conducted at Solohead Research Farm. There were three treatments: (i) A grass-only treatment (FN) stocked at 2.0 cows per ha in 2003 and 2.2 cows per ha during 2004, 2005 and 2006. This treatment received an average of 226 kg per ha of fertilizer N per year during these years. (ii) A grass-clover treatment (WC) stocked at the same rates as FN and received an average of 90 kg per ha of fertilizer N per year during the experiment. (iii) A grass-only treatment (CC) that was gradually converted over to grass-clover during the experiment and stocked at 2.0 cows per ha throughout the experiment. Fertilizer N input was gradually lowered from 150 kg per ha in 2003 to a target of 90 kg per ha in 2005 and 2006

Electromyography of the Mandibular Postural Position in the Rhesus Monkey (Macaca mulatta)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68000/2/10.1177_00220345740530043801.pd

The cervical vertebral maturation method: A user's guide

The cervical vertebral maturation (CVM) method is used to determine the craniofacial skeletal maturational stage of an individual at a specific time point during the growth process. This diagnostic approach uses data derived from the second (C2), third (C3), and fourth (C4) cervical vertebrae, as visualized in a two-dimensional lateral cephalogram. Six maturational stages of those three cervical vertebrae can be determined, based on the morphology of their bodies. The first step is to evaluate the inferior border of these vertebral bodies, determining whether they are flat or concave (ie, presence of a visible notch). The second step in the analysis is to evaluate the shape of C3 and C4. These vertebral bodies change in shape in a typical sequence, progressing from trapezoidal to rectangular horizontal, to square, and to rectangular vertical. Typically, cervical stages (CSs) 1 and CS 2 are considered prepubertal, CS 3 and CS 4 circumpubertal, and CS 5 and CS 6 postpubertal. Criticism has been rendered as to the reproducibility of the CVM method. Diminished reliability may be observed at least in part due to the lack of a definitive description of the staging procedure in the literature. Based on the now nearly 20 years of experience in staging cervical vertebrae, this article was prepared as a “user's guide” that describes the CVM stages in detail in attempt to help the reader use this approach in everyday clinical practice

Does Epileptiform Activity Contribute to Cognitive Impairment in Alzheimer's Disease?

Alzheimer's disease is a devastating neurological disorder. The role of hyperexcitability in the disease's cognitive decline is not completely understood. In this issue of Neuron, Palop et al. report both limbic seizures and presumed homeostatic responses to seizures in an animal model of Alzheimer's

Using Networks To Understand Medical Data: The Case of Class III Malocclusions

A system of elements that interact or regulate each other can be represented by a mathematical object called a network. While network analysis has been successfully applied to high-throughput biological systems, less has been done regarding their application in more applied fields of medicine; here we show an application based on standard medical diagnostic data. We apply network analysis to Class III malocclusion, one of the most difficult to understand and treat orofacial anomaly. We hypothesize that different interactions of the skeletal components can contribute to pathological disequilibrium; in order to test this hypothesis, we apply network analysis to 532 Class III young female patients. The topology of the Class III malocclusion obtained by network analysis shows a strong co-occurrence of abnormal skeletal features. The pattern of these occurrences influences the vertical and horizontal balance of disharmony in skeletal form and position. Patients with more unbalanced orthodontic phenotypes show preponderance of the pathological skeletal nodes and minor relevance of adaptive dentoalveolar equilibrating nodes. Furthermore, by applying Power Graphs analysis we identify some functional modules among orthodontic nodes. These modules correspond to groups of tightly inter-related features and presumably constitute the key regulators of plasticity and the sites of unbalance of the growing dentofacial Class III system. The data of the present study show that, in their most basic abstraction level, the orofacial characteristics can be represented as graphs using nodes to represent orthodontic characteristics, and edges to represent their various types of interactions. The applications of this mathematical model could improve the interpretation of the quantitative, patient-specific information, and help to better targeting therapy. Last but not least, the methodology we have applied in analyzing orthodontic features can be applied easily to other fields of the medical science.</p

Fabrication of the acrylic splint Herbst appliance

This article describes the fabrication of one type of Herbst appliance, a removable or fixed functional appliance that causes the posturing of the mandible in a forward position. The type of Herbst appliance described in this article consists of a wire framework to which are attached the various parts of the Herbst bite-jumping mechanism. The acrylic part of the appliance is fabricated from splint Biocryl or from methylmethacrylate. The steps of the fabrication of the appliance are described in detail.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27439/1/0000478.pd

An electromyographic study of mastication in the rhesus monkey (Macaca mulatta)

Twenty-eight monkeys (Macaca mulatta) were monitored during 84 electromyographic recording sessions to study the function of certain masticatory and facial muscles during mastication. During the period of closing muscle function, strong activity was noted in the temporal and masseter musculature and in the superior head of the lateral pterygoid muscle. The relative participation of the elevator muscles differed among the four age groups. During the period of opening muscle activity, the suprahyoids and the inferior head of the lateral pterygoid muscle functioned during the depression of the lower jaw. A comparison of the results of this study with the numerous human EMG studies of mastication indicate a basic similarity in muscle function during chewing in the two species, although age-related differences in specific muscle group activities do exist.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22292/1/0000732.pd

Diagnostic reliability of the cervical vertebral maturation method and standing height in the identification of the mandibular growth spurt

5siObjective: To evaluate the capability of both cervical vertebral maturation (CVM) stages 3 and 4 (CS3-4 interval) and the peak in standing height to identify the mandibular growth spurt throughout diagnostic reliability analysis. Materials and Methods: A previous longitudinal data set derived from 24 untreated growing subjects (15 females and nine males,) detailed elsewhere were reanalyzed. Mandibular growth was defined as annual increments in Condylion (Co)-Gnathion (Gn) (total mandibular length) and Co-Gonion Intersection (Goi) (ramus height) and their arithmetic mean (mean mandibular growth [mMG]). Subsequently, individual annual increments in standing height, Co-Gn, Co-Goi, and mMG were arranged according to annual age intervals, with the first and last intervals defined as 7-8 years and 15-16 years, respectively. An analysis was performed to establish the diagnostic reliability of the CS3-4 interval or the peak in standing height in the identification of the maximum individual increments of each Co-Gn, Co-Goi, and mMG measurement at each annual age interval. Results: CS3-4 and standing height peak show similar but variable accuracy across annual age intervals, registering values between 0.61 (standing height peak, Co-Gn) and 0.95 (standing height peak and CS3-4, mMG). Generally, satisfactory diagnostic reliability was seen when the mandibular growth spurt was identified on the basis of the Co-Goi and mMG increments. Conclusions: Both CVM interval CS3-4 and peak in standing height may be used in routine clinical practice to enhance efficiency of treatments requiring identification of the mandibular growth spurt.openopenPerinetti, Giuseppe; Contardo, Luca; Castaldo, Attilio; Mcnamara, James A.; Franchi, LorenzoPerinetti, Giuseppe; Contardo, Luca; Castaldo, Attilio; Mcnamara, James A.; Franchi, Lorenz