Inhomogeneous Einstein-Rosen String Cosmology

Families of anisotropic and inhomogeneous string cosmologies containing non-trivial dilaton and axion fields are derived by applying the global symmetries of the string effective action to a generalized Einstein-Rosen metric. The models exhibit a two-dimensional group of Abelian isometries. In particular, two classes of exact solutions are found that represent inhomogeneous generalizations of the Bianchi type VI_h cosmology. The asymptotic behaviour of the solutions is investigated and further applications are briefly discussed.Comment: Minor extension of concluding section; 18 pages, to appear in Phys.Rev.

Moving Five-Branes in Low-Energy Heterotic M-Theory

We construct cosmological solutions of four-dimensional effective heterotic M-theory with a moving five-brane and evolving dilaton and T modulus. It is shown that the five-brane generates a transition between two asymptotic rolling-radii solutions. Moreover, the five-brane motion always drives the solutions towards strong coupling asymptotically. We present an explicit example of a negative-time branch solution which ends in a brane collision accompanied by a small-instanton transition. The five-dimensional origin of some of our solutions is also discussed.Comment: 16 pages, Latex, 3 eps figure

Defining childhood severe falciparum malaria for intervention studies.

Background Clinical trials of interventions designed to prevent severe falciparum malaria in children require a clear endpoint. The internationally accepted definition of severe malaria is sensitive, and appropriate for clinical purposes. However, this definition includes individuals with severe nonmalarial disease and coincident parasitaemia, so may lack specificity in vaccine trials. Although there is no “gold standard” individual test for severe malaria, malaria-attributable fractions (MAFs) can be estimated among groups of children using a logistic model, which we use to test the suitability of various case definitions as trial endpoints. Methods and Findings A total of 4,583 blood samples were taken from well children in cross-sectional surveys and from 1,361 children admitted to a Kenyan District hospital with severe disease. Among children under 2 y old with severe disease and over 2,500 parasites per microliter of blood, the MAFs were above 85% in moderate- and low-transmission areas, but only 61% in a high-transmission area. HIV and malnutrition were not associated with reduced MAFs, but gastroenteritis with severe dehydration (defined by reduced skin turgor), lower respiratory tract infection (clinician's final diagnosis), meningitis (on cerebrospinal fluid [CSF] examination), and bacteraemia were associated with reduced MAFs. The overall MAF was 85% (95% confidence interval [CI] 83.8%–86.1%) without excluding these conditions, 89% (95% CI 88.4%–90.2%) after exclusions, and 95% (95% CI 94.0%–95.5%) when a threshold of 2,500 parasites/μl was also applied. Applying a threshold and exclusion criteria reduced sensitivity to 80% (95% CI 77%–83%). Conclusions The specificity of a case definition for severe malaria is improved by applying a parasite density threshold and by excluding children with meningitis, lower respiratory tract infection (clinician's diagnosis), bacteraemia, and gastroenteritis with severe dehydration, but not by excluding children with HIV or malnutrition

Embeddings in Non-Vacuum Spacetimes

A scheme is discussed for embedding n-dimensional, Riemannian manifolds in an (n+1)-dimensional Einstein space. Criteria for embedding a given manifold in a spacetime that represents a solution to Einstein's equations sourced by a massless scalar field are also discussed. The embedding procedures are illustrated with a number of examples.Comment: 17 pages, Plain Latex. Extended discussion on embeddings with scalar fields and further examples included. In press, Classical and Quantum Gravit

Supersymmetric Quantization of Anisotropic Scalar-Tensor Cosmologies

In this paper we show that the spatially homogeneous Bianchi type I and Kantowski-Sachs cosmologies derived from the Brans-Dicke theory of gravity admit a supersymmetric extension at the quantum level. Global symmetries in the effective one-dimensional actions characterize both classical and quantum solutions. A wide family of exact wavefunctions satisfying the supersymmetric constraints are found. A connection with quantum wormholes is briefly discussed.Comment: In Press, Class. Quantum Grav. 20 pages, Late

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury

Proximal tubule cells (PTCs), which are the primary site of kidney injury associated with ischemia or nephrotoxicity, are the site of oligonucleotide reabsorption within the kidney. We exploited this property to test the efficacy of siRNA targeted to p53, a pivotal protein in the apoptotic pathway, to prevent kidney injury. Naked synthetic siRNA to p53 injected intravenously 4 h after ischemic injury maximally protected both PTCs and kidney function. PTCs were the primary site for siRNA uptake within the kidney and body. Following glomerular filtration, endocytic uptake of Cy3-siRNA by PTCs was rapid and extensive, and significantly reduced ischemia-induced p53 upregulation. The duration of the siRNA effect in PTCs was 24 to 48 h, determined by levels of p53 mRNA and protein expression. Both Cy3 fluorescence and in situ hybridization of siRNA corroborated a short t½ for siRNA. The extent of renoprotection, decrease in cellular p53 and attenuation of p53-mediated apoptosis by siRNA were dose- and time-dependent. Analysis of renal histology and apoptosis revealed improved injury scores in both cortical and corticomedullary regions. siRNA to p53 was also effective in a model of cisplatin-induced kidney injury. Taken together, these data indicate that rapid delivery of siRNA to proximal tubule cells follows intravenous administration. Targeting siRNA to p53 leads to a dose-dependent attenuation of apoptotic signaling, suggesting potential therapeutic benefit for ischemic and nephrotoxic kidney injury

Symmetries for generating string cosmologies

We discuss the symmetry properties of the low-energy effective action of the type IIB superstring that may be employed to derive four-dimensional solutions. A truncated effective action, compactified on a six-torus, but including both Neveu/Schwarz-Neveu/Schwarz and Ramond-Ramond field strengths, can be expressed as a non-linear sigma model which is invariant under global SL(3,R) transformations. This group contains as a sub-group the SL(2,R) symmetry of the ten-dimensional theory and a discrete Z2 reflection symmetry which leads to a further SL(2,R) sub-group. The symmetries are employed to analyse a general class of spatially homogeneous cosmological solutions with non-trivial Ramond-Ramond fields.Comment: Substantially extended version with new sections on further symmetries and anisotropic cosmological solutions. New title. To appear in Physical Review D. 13 pages, LaTeX, no figure

Effects of anisotropy and spatial curvature on the pre-big bang scenario

A class of exact, anisotropic cosmological solutions to the vacuum Brans-Dicke theory of gravity is considered within the context of the pre-big bang scenario. Included in this class are the Bianchi type III, V and VI_h models and the spatially isotropic, negatively curved Friedmann-Robertson-Walker universe. The effects of large anisotropy and spatial curvature are determined. In contrast to negatively curved Friedmann-Robertson-Walker model, there exist regions of the parameter space in which the combined effects of curvature and anisotropy prevent the occurrence of inflation. When inflation is possible, the necessary and sufficient conditions for successful pre-big bang inflation are more stringent than in the isotropic models. The initial state for these models is established and corresponds in general to a gravitational plane wave.Comment: 15 pages, including 2 eps figure

The McKenna Rule and U.K. World War I Finance

The United Kingdom employed the McKenna rule to conduct fiscal policy during World War I (WWI) and the interwar period. Named for Reginald McKenna, Chancellor of the Exchequer (1915–16), the McKenna rule committed the United Kingdom to a path of debt retirement, which we show was forward-looking and smoothed in response to shocks to the real economy and tax rates. The McKenna rule was in the tradition of the English method of war finance because the United Kingdom taxed capital to finance WWI. Higher rates of capital taxation also paid for debt retirement during and subsequent to WWI. The United Kingdom was motivated to implement the McKenna rule because of a desire to achieve a balance between fairness and equity. However, the McKenna rule adversely affected the real economy, according to a permanent income model. WWI and interwar U.K. data support the prediction that real activity is lower in response to higher past debt retirement rates