Aging and the Detection of Visual Errors in Scenes

Young and older adults performed a visual error detection task in two experiments. In Experiment 1, errors and anomalies were embedded in large, complex visual scenes, and participants were to find them and describe the nature of the identified problems. Young adults found more errors than older adults, a finding unrelated to age differences in near visual acuity or time constraints. Experiment 2 replicated the age difference in error detection using simplified visual scenes containing fewer errors. Results are interpreted as reflecting older adults' decreased ability to form representations for novel information, even though the task did not require the creation of new episodic memories

Quality and Publication of Emergency Medicine Trials Registered in ClinicalTrials.gov

Introduction: Promoting emergency medicine (EM) clinical trials research remains a priority. To characterize the status of clinical EM research, this study assessed trial quality, funding source, and publication of EM clinical trials and compared EM and non-EM trials on these key metrics. We also examined the volume of EM trials and their subspecialty areas.Methods: We abstracted data from ClinicalTrials.gov (February 2000 - September 2013) and used individual study National Clinical Trial numbers to identify published trials (January 2007 - September 2016). We used descriptive statistics and chi-square tests to examine study characteristics by EM and non-EM status, and Kaplan-Meier curves and log-rank tests to compare time to publication of completed EM and non-EM studies.Results: We found 638 interventional EM trials and 59,512 non-EM interventional trials conducted in the United States between February 2000 and September 2013, registered on ClinicalTrials.gov. EM studies were significantly less likely than non-EM studies to be National Institutes of Health-funded or to evaluate a drug or biologic. However, EM studies had significantly larger sample sizes, and were significantly more likely to use randomization and blinding. Overall, 34.3% of EM and 26.0% of non-EM studies were published in peer-reviewed journals. By subspecialty, more EM trials concerned medical/surgical and psychiatric/neurological conditions than trauma.Conclusion: Although EM studies were less likely to have received federal or industry funding, and the EM portfolio consisted of only 638 trials over the 14-year study period, the quality of EM trials surpassed that of non-EM trials, based on indices such as randomization and blinding. This novel finding bodes well for the future of clinical EM research, as does the higher proportion of published EM than non-EM trials. Our study also revealed that trauma studies were under-represented among EM studies. Periodic assessment of EM trials with the metrics used here could provide an informative and valuable longitudinal view of progress in clinical EM research

Age-Related Increases in Verbal Knowledge Are Not Associated With Word Finding Problems in the Cam-CAN Cohort: What You Know Won't Hurt You.

Objective: We tested the claim that age-related increases in knowledge interfere with word retrieval, leading to word finding failures. We did this by relating a measure of crystallized intelligence to tip-of-the-tongue (TOT) states and picture naming accuracy. Method: Participants were from a large (N = 708), cross-sectional (aged 18-88 years), population-based sample from the Cambridge Centre for Ageing and Neuroscience cohort (Cam-CAN; www.cam-can.com). They completed (a) the Spot-the-Word Test (STW), a measure of crystallized intelligence in which participants circled the real word in word/nonword pairs, (b) a TOT-inducing task, and (c) a picture naming task. Results: Age and STW independently predicted TOTs, with higher TOTs for older adults and for participants with lower STW scores. Tests of a moderator model examining interactions between STW and age indicated that STW was a significant negative predictor of TOTs in younger adults, but with increasing age, the effect size gradually approached zero. Results using picture naming accuracy replicated these findings. Discussion: These results do not support the hypothesis that lifelong knowledge acquisition leads to interference that causes an age-related increase in TOTs. Instead, crystallized intelligence supports successful word retrieval, although this relationship weakens across adulthood

The NGC 7129 Young Stellar Cluster: A Combined Spitzer, MMT, and 2MASS Census of Disks, Protostars, and Outflows

We present the analysis of seven band (1.2 to 8 micron) ground and space-based imaging of the NGC 7129 young stellar cluster from FLAMINGOS on MMT, 2MASS, and the Infrared Array Camera (IRAC) on the Spitzer Space Telescope. An analysis of the H-[4.5] vs. J-H colors reveals 84 objects with circumstellar disks. Of these, 42 are located within the cluster core, a 0.5 pc (100'') radius region of enhanced stellar surface density. From a luminosity and extinction limited sample of the stars within the cluster core boundary we have determined that 54% +/- 14% have circumstellar disks. Finally, we report the detection of several resolved outflows in the IRAC 4.5 micron mosaic.Comment: 13 pages, 4 figures. Accepted to the Spitzer special issue of ApJS. The full-resolution preprint can be obtained from http://astro.pas.rochester.edu/~rguter/preprints/gutermuth_ngc7129_a.tar.g

Mad Is Required for Wingless Signaling in Wing Development and Segment Patterning in Drosophila

A key question in developmental biology is how growth factor signals are integrated to generate pattern. In this study we investigated the integration of the Drosophila BMP and Wingless/GSK3 signaling pathways via phosphorylations of the transcription factor Mad. Wingless was found to regulate the phosphorylation of Mad by GSK3 in vivo. In epistatic experiments, the effects of Wingless on wing disc molecular markers (senseless, distalless and vestigial) were suppressed by depletion of Mad with RNAi. Wingless overexpression phenotypes, such as formation of ectopic wing margins, were induced by Mad GSK3 phosphorylation-resistant mutant protein. Unexpectedly, we found that Mad phosphorylation by GSK3 and MAPK occurred in segmental patterns. Mad depletion or overexpression produced Wingless-like embryonic segmentation phenotypes. In Xenopus embryos, segmental border formation was disrupted by Smad8 depletion. The results show that Mad is required for Wingless signaling and for the integration of gradients of positional information

Report on the State of Available Data for the Study of International Trade and Foreign Direct Investment

This report, prepared for the Committee on Economic Statistics of the American Economic Association, examines the state of available data for the study of international trade and foreign direct investment. Data on values of imports and exports of goods are of high quality and coverage, but price data suffer from insufficient detail. It would be desirable to have more data measuring value-added in trade as well as prices of comparable domestic and imported inputs. Value data for imports and exports of services are too aggregated and valuations are questionable, while price data for service exports and imports are almost non-existent. Foreign direct investment data are of high quality but quality has suffered from budget cuts. Data on trade in intellectual property are fragmentary. The intangibility of the trade makes measurement difficult, but budget cuts have added to the difficulties. Modest funding increases would result in data more useful for research and policy analysis.

The Spitzer c2d Survey of Nearby Dense Cores: III: Low Mass Star Formation in a Small Group, L1251B

We present a comprehensive study of a low-mass star-forming region,L1251B, at wavelengths from the near-infrared to the millimeter. L1251B, where only one protostar, IRAS 22376+7455, was known previously, is confirmed to be a small group of protostars based on observations with the Spitzer Space Telescope. The most luminous source of L1251B is located 5" north of the IRAS position. A near-infrared bipolar nebula, which is not associated with the brightest object and is located at the southeast corner of L1251B, has been detected in the IRAC bands. OVRO and SMA interferometric observations indicate that the brightest source and the bipolar nebula source in the IRAC bands are deeply embedded disk sources.Submillimeter continuum observations with single-dish telescopes and the SMA interferometric observations suggest two possible prestellar objects with very high column densities. Outside of the small group, many young stellar object candidates have been detected over a larger region of 12' x 12'. Extended emission to the east of L1251B has been detected at 850 micron; this "east core" may be a site for future star formation since no point source has been detected with IRAC or MIPS. This region is therefore a possible example of low-mass cluster formation, where a small group of pre- and protostellar objects (L1251B) is currently forming, alongside a large starless core (the east core).Comment: 35 pages, 15 figures, accepted for publication in ApJ, for the full resolution paper, visit "http://peggysue.as.utexas.edu/SIRTF/PAPERS/pap27.pub.pdf