3 research outputs found
Clinical Performance of Two Methods for Detecting Anti SARS-CoV-2 Antibodies
Evaluating the clinical performance of available methods to detect antibodies against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has become a primordial issue in clinical laboratories. The aim of this study was to evaluate the clinical performance of two methods for SARS-CoV-2 antibodies detection, an automated Chemiluminescent Immunoassay (CLIA) and an immunochromatographic Lateral-Flow Assay (LFA) in patients with positive reverse transcription polymerase chain reaction (RT-PCR). Performance for CLIA method was Positive Agreement (PA) 56.6% and Negative Agreement (NA) 96,6% for IgM and PA 85.8%/NA 90,2% for IgG. Performance for LFA method was PA 56.2% and NA 100% for IgM and PA 95.5% and NA 100 % for IgG. LFA general agreement IgG was better than CLIA. In both methods, significant differences in Kappa index are observed when IgG and IgM are compared. When evaluating the data from a clinical perspective, we found that both method performance for IgM detection may not meet the expected requirements for their clinical utility and could lead to an inappropriate medical decision. The findings of this study show that both immunoassay methods might be reliable for assessing immunological response in COVID-19 patients. Our results also confirm that IgG measurement could be helpful, especially for epidemiological studies in our population. These results provide evidence to justify epidemiological studies in our population.Fil: Jacobsen, Dario Gustavo. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Gonzalez, D.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de FisiopatologĂa y BioquĂmica ClĂnica; ArgentinaFil: Jamardo, J.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Ibar, C.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Pugliese, L.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Fortuna, F.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Carrizo, E.. Coordinadora de Salud Misionar; ArgentinaFil: Caro, E. M.. Laboratorio Biogenar; ArgentinaFil: Perazzi, Beatriz Elizabeth. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de FisiopatologĂa y BioquĂmica ClĂnica; ArgentinaFil: Repetto, Esteban MartĂn. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Reboredo, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Fabre, B.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de FisiopatologĂa y BioquĂmica ClĂnica; Argentin
The neurobiological hypothesis of neurotrophins in the pathophysiology of schizophrenia: A meta-analysis
Schizophrenia is associated with patterns of aberrant neurobiological circuitry. The disease complexity is mirrored by multiple biological interactions known to contribute to the disease pathology. One potential contributor is the family of neurotrophins which are proteins involved in multiple functional processes in the nervous system, with crucial roles in neurodevelopment, synaptogenesis and neuroplasticity. With these roles in mind, abnormal neurotrophin profiles have been hypothesized to contribute to the pathology of schizophrenia.CS is supported by the FundaciĂłn Tatiana PĂ©rez de Guzman el Bueno and Rede Galega de InvestigaciĂłn en DemenciasIN607C-2017/02, GAIN, Xunta de Galicia, JMO is supported by ISCIIIP16/00405, RCAB is funded by FEDER, a RamĂłn& Cajal grant (RYC-2014-15246) and the Galicia Innovation Agency - GAIN grant (IN607D-2016/003)info:eu-repo/semantics/publishedVersio