4 research outputs found
A case report of Thymolipoma
A 30 years old female presented with dyspenea, tachycardia and post sternal pain of one year ago in ECG and echocardiography pericardial effusion is suggested there was a large mass M.20×12×5 cm in mediastinum in thymic zone and thymus was not present. The mass was well circumbscribed and encapsulated without invasion to other viscera. The pathology reported as a thymolipom
Relationship between genetic polymorphism of <i>glutathione S-transferase-p1</i> and p53 protein accumulation in Iranian esophageal squamous cell carcinoma patients
Background: It has been reported that the activity of glutathione
S-transferase (GST) is over-expressed in plasma and esophagus biopsies
in Iranian patients suffering from esophageal squamous cell carcinoma
(SCC). The aim of this study was to find out the frequency of GST-P
genotypes in these patients. Moreover, the association of GST-P
genotypes with p53 protein accumulation in esophageal epithelium was
investigated. Materials and Methods: DNA isolated from
paraffin-embedded tissue biopsies from patients suffering from
esophageal SCC (n = 56) were collected. polymerase chain
reaction-restriction fragment length polymorphism (PCR-RFLP) using
Alw261 enzyme was applied to determine GST-P genotypes (Ile 105 Val).
All the samples were also subjected to immunohistochemistry (IHC) for
p53. Results: The frequency of GST-P genotypes in Iranian esophagus SCC
patients for Ile/Ile, Ile/Val and Val/Val was 73.2, 21.5 and 5.3%.
There was no association between GST-P polymorphism and p53
accumulation in esophageal epithelial cells. Conclusions: The frequency
of GST-P polymorphism was not associated with p53 protein accumulation
in esophagus epithelium. The frequency of polymorphic variants of
GST-P, Ile/Ile, Ile/Val and Val/Val in SCC patients may suggest that
Ile to Val substitution in GST-P gene dose not represent susceptibility
to SCC in high-risk Iranian population
Relationship between genetic polymorphism of glutathione S-transferase-p1 and p53 protein accumulation in Iranian esophageal squamous cell carcinoma patients
Background: It has been reported that the activity of glutathione
S-transferase (GST) is over-expressed in plasma and esophagus biopsies
in Iranian patients suffering from esophageal squamous cell carcinoma
(SCC). The aim of this study was to find out the frequency of GST-P
genotypes in these patients. Moreover, the association of GST-P
genotypes with p53 protein accumulation in esophageal epithelium was
investigated. Materials and Methods: DNA isolated from
paraffin-embedded tissue biopsies from patients suffering from
esophageal SCC (n = 56) were collected. polymerase chain
reaction-restriction fragment length polymorphism (PCR-RFLP) using
Alw261 enzyme was applied to determine GST-P genotypes (Ile 105 Val).
All the samples were also subjected to immunohistochemistry (IHC) for
p53. Results: The frequency of GST-P genotypes in Iranian esophagus SCC
patients for Ile/Ile, Ile/Val and Val/Val was 73.2, 21.5 and 5.3%.
There was no association between GST-P polymorphism and p53
accumulation in esophageal epithelial cells. Conclusions: The frequency
of GST-P polymorphism was not associated with p53 protein accumulation
in esophagus epithelium. The frequency of polymorphic variants of
GST-P, Ile/Ile, Ile/Val and Val/Val in SCC patients may suggest that
Ile to Val substitution in GST-P gene dose not represent susceptibility
to SCC in high-risk Iranian population
Relationship between genetic polymorphism of glutathione S-transferase-p1 and p53 protein accumulation in Iranian esophageal squamous cell carcinoma patients
Background: It has been reported that the activity of glutathione
S-transferase (GST) is over-expressed in plasma and esophagus biopsies
in Iranian patients suffering from esophageal squamous cell carcinoma
(SCC). The aim of this study was to find out the frequency of GST-P
genotypes in these patients. Moreover, the association of GST-P
genotypes with p53 protein accumulation in esophageal epithelium was
investigated. Materials and Methods: DNA isolated from
paraffin-embedded tissue biopsies from patients suffering from
esophageal SCC (n = 56) were collected. polymerase chain
reaction-restriction fragment length polymorphism (PCR-RFLP) using
Alw261 enzyme was applied to determine GST-P genotypes (Ile 105 Val).
All the samples were also subjected to immunohistochemistry (IHC) for
p53. Results: The frequency of GST-P genotypes in Iranian esophagus SCC
patients for Ile/Ile, Ile/Val and Val/Val was 73.2, 21.5 and 5.3%.
There was no association between GST-P polymorphism and p53
accumulation in esophageal epithelial cells. Conclusions: The frequency
of GST-P polymorphism was not associated with p53 protein accumulation
in esophagus epithelium. The frequency of polymorphic variants of
GST-P, Ile/Ile, Ile/Val and Val/Val in SCC patients may suggest that
Ile to Val substitution in GST-P gene dose not represent susceptibility
to SCC in high-risk Iranian population