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Molecular origins of surfactant stabilization of a human recombinant factor VIII
The project objective was to characterize stabilization of human recombinant Factor VIII (FVIII) with two surfactants, Pluronic® F-68 (F68) and Polysorbate 80 (PS80). Factor VIII is an essential blood clotting protein manufactured for treatment of Hemophilia A. Factor VIII has multiple hydrophobic regions requiring the use of amphiphilic molecules, such as surfactants, to stabilize the protein in aqueous solutions. Over half of FVIII produced is lost due to adsorption and aggregation during current downstream processing using PS80. Du Nouy ring interfacial tensiometry was used to measure surface tension depression of surfactant samples ranging from 10-150 ppm with and without 60-70 IU/mL FVIII injected into KG-2 buffer at temperatures ranging from 4 to 60 °C. Addition of FVIII caused the rate of surface tension depression to increase by 15% in PS80 and decrease by 26% in F68. Surface tension depression data indicates that PS80 preferentially binds to the air-water interface while F68 prefers to associate with FVIII, helping to stabilize the protein in solution and prevent adsorptive and aggregative losses. The results suggest that FVIII yield could be substantially improved by the replacement of PS80 with F68 in commercial production
Testing CPT- and Lorentz-odd electrodynamics with waveguides
We study CPT- and Lorentz-odd electrodynamics described by the Standard Model
Extension. Its radiation is confined to the geometry of hollow conductor
waveguide, open along . In a special class of reference frames, with
vanishing both 0-th and components of the background field, , we realize a number of {\em huge and macroscopically detectable}
effects on the confined waves spectra, compared to standard results.
Particularly, if points along (or ) direction only
transverse electric modes, with , should be observed propagating
throughout the guide, while all the transverse magnetic, , are absent.
Such a strong mode suppression makes waveguides quite suitable to probe these
symmetry violations using a simple and easily reproducible apparatus.Comment: 11pages, double-spacing, tex forma
The Eighteenth Data Release of the Sloan Digital Sky Surveys: Targeting and First Spectra from SDSS-V
The eighteenth data release of the Sloan Digital Sky Surveys (SDSS) is the
first one for SDSS-V, the fifth generation of the survey. SDSS-V comprises
three primary scientific programs, or "Mappers": Milky Way Mapper (MWM), Black
Hole Mapper (BHM), and Local Volume Mapper (LVM). This data release contains
extensive targeting information for the two multi-object spectroscopy programs
(MWM and BHM), including input catalogs and selection functions for their
numerous scientific objectives. We describe the production of the targeting
databases and their calibration- and scientifically-focused components. DR18
also includes ~25,000 new SDSS spectra and supplemental information for X-ray
sources identified by eROSITA in its eFEDS field. We present updates to some of
the SDSS software pipelines and preview changes anticipated for DR19. We also
describe three value-added catalogs (VACs) based on SDSS-IV data that have been
published since DR17, and one VAC based on the SDSS-V data in the eFEDS field.Comment: Accepted to ApJ
The eighteenth data release of the Sloan Digital Sky Surveys : targeting and first spectra from SDSS-V
The eighteenth data release of the Sloan Digital Sky Surveys (SDSS) is the first one for SDSS-V, the fifth generation of the survey. SDSS-V comprises three primary scientific programs, or "Mappers": Milky Way Mapper (MWM), Black Hole Mapper (BHM), and Local Volume Mapper (LVM). This data release contains extensive targeting information for the two multi-object spectroscopy programs (MWM and BHM), including input catalogs and selection functions for their numerous scientific objectives. We describe the production of the targeting databases and their calibration- and scientifically-focused components. DR18 also includes ~25,000 new SDSS spectra and supplemental information for X-ray sources identified by eROSITA in its eFEDS field. We present updates to some of the SDSS software pipelines and preview changes anticipated for DR19. We also describe three value-added catalogs (VACs) based on SDSS-IV data that have been published since DR17, and one VAC based on the SDSS-V data in the eFEDS field.Publisher PDFPeer reviewe