Chronic granulomatous disease: a review of the infectious and inflammatory complications

Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formation of granulomas in tissue. The disease is the result of a disorder of the NADPH oxidase system, culminating in an inability of the phagocyte to generate superoxide, leading to the defective killing of pathogenic organisms. This can lead to infections with Staphylococcus aureus, Psedomonas species, Nocardia species, and fungi (such as Aspergillus species and Candida albicans). Involvement of vital or large organs can contribute to morbidity and/or mortality in the affected patients. Major advances have occurred in the diagnosis and treatment of this disease, with the potential for gene therapy or stem cell transplantation looming on the horizon

Juice Consumption among Children Aged 9 to 24 Months Participating in Women, Infant, Children (WIC) Program

Abstract is available in Pediatrics

Juice Consumption among Children Aged 9 to 24 Months Participating in Women, Infant, Children (WIC) Program

Abstract is available in Pediatrics

Improving the Provision of Health Information and Support to Parents and Caregivers through Online Data Collection

As part of the ReadNPlay for a Bright Future initiative, an online survey was conducted to determine the preferences of parents and caregivers in regards to receiving health information and support and to identify opportunities to improve existing support groups in Northeast Tennessee. An anonymous online survey with ten closed-ended questions was designed on Survey Monkey and posted on social media sites of the ReadNPlay project, BABE Regional Breastfeeding Coalition, and local mothers’ support groups. After a two-week period, during which a reminder of the survey was posted, the results of the survey were summarized using Survey Monkey and Excel. A total of 39 surveys were collected. Of the 39 participants, all identified themselves as either a mother (97.44%) or other female caregiver (2.56%). Sixty three percent of mothers and caregivers wanted to receive support or health information through face-to-face support group meetings compared to 78.95% who wanted to receive the same information through social media and 68.42% who wanted to receive information via email. Less popular options for receiving health information and support include community events (60.53%), classes (44.74%), text messages (36.84%), childcare centers/schools (34.21%), handouts from healthcare providers (28.95%), and snail mail (21.05%). Forty six percent of respondents have attended support group meetings several times, 41.03% have never attended a support group meeting, and 15.38% have only attended a support group meeting once. Mothers and other caregivers identified the greatest barriers to participation in a support group as inconvenient timing (47.22%), lack of time (50%), inconvenient locations (47.22%), and lack of information about time and location (25%). Respondents were interested in receiving the following health and parenting information: learning/development (83.78%) breastfeeding (75.68%), active play (75.68%), behavior (72.97%), nutrition (64.86%), safety (45.95%), and prevention (40.54%). Mothers and other caregivers were interested in receiving the following types of support when they attend group meetings: socialization with other parents (81.58%), activities sponsored by community organization (78.95%), information about community resources (65.79%), parenting tips (63.16%), health information (44.74%), and food and supplies (34.21%).Additionally, when respondents were asked to identify preferred locations for support group meetings, the most popular option was a kid-friendly location (97.37%) followed by a community center (57.89%). The results obtained above are being used to improve existing support groups by providing parents and caregivers with child-friendly environments in which to socialize and receive a variety of parenting information, including information on learning and development

Juice Consumption among Children Aged 9 to 24 Months Participating in Women, Infants, and Children (WIC) Program

INTRODUCTION: One out of every 100 deaths from an obesity-related disease is caused by sugary drink consumption. The National Center for Health Statistics reported in 2010, sugary beverages like soda, fruit drinks, sports drinks, sweet tea, and energy drinks accounted for 46% of all added sugars in the American diet. According to the Youth Risk Behavior Surveillance in 2013, 27% of teens drank one or more soda per day, 19% drank two or more, and 11% drank three or more. Research has shown each additional 12 ounce soda a child consumes each day, attributes to an increased 60% chance of becoming obese during one and a half years of follow up time. Sugary drink consumption, childhood obesity, and low socio-economic status have been linked to increased likelihood of obesity during adulthood. Woman, Infants, and Children (WIC) is a special supplemental nutrition program hoping to improve the health of low income pregnant, postpartum, and breastfeeding mothers and their infants and children up to the age of 5. WIC provides food, nutrition education, breastfeeding promotion and referrals to health services at no charge. The WIC program is designed to supplement the participant’s diet. According to food packages in Tennessee, mothers are allowed to buy 100% fruit juice in the form of two 64 ounce bottles, 48 ounces shelf stable or frozen reconstitute, three 48 ounce bottles, or one 96 ounce bottle. This study compares sugary drink consumption of WIC-participating infants and mothers to non WIC participants and aims to identify any disparities. METHODS: Data were obtained through ReadNPlay for a Bright Future, a program advocating for healthy active living among families with young children. Surveys were generated to assess the health and demographics of mothers and their children living in the area. A convenience sample was utilized by voluntary and anonymous submission of surveys by mothers with babies aged 9-24 months, who visited a local pediatric clinic. Collection of 320 surveys was achieved during four separate time frames within 2013-2015. The association between sugary drink consumption in children and WIC is being examined using linear regression. RESULTS: Preliminary data analysis revealed 69.3% of the total sample (n=226) was enrolled in WIC. 89% of mothers reported having a high school degree during the most recent data collection. Mothers reported their infants consumed an average of 4.6 ounces of sugary drinks daily (range 1-15 ounces). 66.4% of mothers reported consuming at least one sugary drink daily, while 27.1% reported consuming 3 or more daily. CONCLUSION: The American Academy of Pediatrics recommends infants and children should be given milk or water instead of 100% fruit juice to reduce the amount of unneeded calories and sugar. If juice is given it is recommended to limit consumption to 4-6 ounces per day. Some types of 100% fruit juice, such as grape juice, have more sugar per ounce than soda. The results of this analysis may help to evaluate the healthfulness of the current WIC food package and identify high risk groups for counseling on sugary drink consumption

Identifying Parental Perspectives on Healthy Eating and Mobile Application Usage

Purpose ReadNPlay for a Bright Future develops a variety of projects aimed at promoting healthy living in families with young children in Appalachian Tennessee. The purposes of this research are to collect parents’ and caregivers’ perspectives on healthy eating for the purpose of designing a new book in the ReadNPlay children\u27s book series to be entitled A Farmers Market Adventure and to collect the preferences of parents and guardians related to website and mobile application (app) usage to help shape the development of a new ReadNPlay My Baby Book app. Methods Anonymous clipboard surveys were administered to attendees of regional community events during July of 2014. Survey items asked parents about healthy eating in the context of their families and the role of parenting websites and mobile apps in their families. The results from these surveys were summarized using Excel. A total of 100 surveys were collected. Results It was found that when parents were asked to identify barriers to healthy eating, the most common responses were picky eaters in the household (30%) followed by lack of time (22%). When asked to identify things that have helped parents to encourage healthy eating in their families, the three most common responses were good recipes (20%), good role models (16%), and farmers markets (16%). Twenty-eight percent of parents surveyed do not use websites or apps for parenting, while those who do use parenting websites or apps identified advice from experts (20%) and advice from other parents (18%) to be the two features most commonly desired in such a resource. When asked what they do not like about website and app usage, 20% of parents indicated that these tools are “too complicated.” However, when parents are told that our group of pediatricians was developing a free mobile application for families designed to help them keep track of their baby’s growth, development, and eating habits, 75% of parents said such an app would be very helpful to them (25% said a little helpful). Conclusion These results will inform a new ReadNPlay children\u27s book themed around healthy eating behaviors, overcoming pickiness, and shopping with families at farmers markets and a new ReadNPlay mobile app for families to use in conjunction with infant-toddler well child visits