Three Rooted Maxillary Second Premolar: A Rare Clinical Finding

Endodontic failure can be due extra canals in the root morphology left untreated by the clinician. Careful assessment and modifications may be required in the cavity preparation for stress free entry to complex root anatomy. This case report depicts a 36- year old male with three roots in his maxillary second mola

Abnormal uterine bleeding: a critical analysis of two diagnostic methods

Background: Abnormal Uterine Bleeding (AUB) is one of the most common reasons for women to seek gynaecology   consultation. The underlying causes in AUB are many and identifying the exact cause can be a real challenge to the treating gynaecologists. Objectives of current study are to study the common etiology of AUB and to study and correlate the diagnoses of Trans Vaginal Sonography (TVS) and Diagnostic Hysteroscopy (DH) with histopathology diagnosis.Methods: One hundred and thirteen women with AUB were enrolled and evaluated by conventional TVS and DH. The findings were correlated with histopathology diagnosis. The sensitivity, specificity and positive and negative predictive value of TVS and DH were calculated after comparison with final histopathology diagnosis.Results: Fibroids and polyps were the two commonest structural lesions in AUB. For submucosal fibroids, the sensitivity and specificity of DH was found to be 92% and 99% respectively while that of TVS was found to be 85 % and 100 % respectively. For polyps, the sensitivity and specificity of DH was found to be 91% and 98 % respectively and that of TVS was 68% and 93 % respectively. The coefficient of correlation for DH was better than that of TVS.Conclusions: Fibroids and polyps are the two commonest structural lesions causing AUB in the women of reproductive age group.  TVS has a role as primary screening method for the initial work-up AUB before resorting to invasive procedure such as hysteroscopy

Recommendations for evaluation of computational methods

The field of computational chemistry, particularly as applied to drug design, has become increasingly important in terms of the practical application of predictive modeling to pharmaceutical research and development. Tools for exploiting protein structures or sets of ligands known to bind particular targets can be used for binding-mode prediction, virtual screening, and prediction of activity. A serious weakness within the field is a lack of standards with respect to quantitative evaluation of methods, data set preparation, and data set sharing. Our goal should be to report new methods or comparative evaluations of methods in a manner that supports decision making for practical applications. Here we propose a modest beginning, with recommendations for requirements on statistical reporting, requirements for data sharing, and best practices for benchmark preparation and usage

Hair tourniquet syndrome of labia minora in 14 year teen: a rare case report

Hair tourniquet syndrome (HTS) is rare clinical phenomenon in which body appendage is circumferentially entangled by string of hair leading to ischemia and necrosis or even autoamputation of the appendage. HTS commonly affects toes, finger or genitalia. Early diagnosis and prompt intervention lead to good outcome.  This article presents a case of hair tourniquet syndrome of labia minora, a rare presentation in 14 year child

Change in spin-down rate and detection of emission line in HMXB 4U 2206+54 with AstroSat observation

This work presents timing and spectral analysis of 4U 2206+54 using data obtained from LAXPC instrument onboard India's AstroSat mission. This source was observed with AstroSat in September 2016 and October 2016. We report detection of $5648 (4)$ s pulsations at MJD 57669 in the latter observation of 4U 2206+54. The pulse profile is sinusoidal and the inherent shape is independent of energy up to 30 keV. The pulse fraction increases with energy from $\sim 0.5$% to $\sim 0.8$%. We report an updated spin down rate of $2.95 (14) \times 10^{-7}$ s s$^{-1}$. This is about 0.40 times smaller than the previously reported long term value. The energy spectrum is best modelled with an absorbed power-law with high energy exponential cut-off. We have detected presence of broad emission line in 4U 2206+54 at an energy of $7$ keV with equivalent width of $\sim 0.4$ keV.Comment: Accepted in Journal of Astrophysics and Astronom