1 research outputs found
Copper(II) Triflate As a Reusable Catalyst for the Synthesis of <i>trans</i>-4,5-Diamino-cyclopent-2-enones in Water
<i>trans</i>-4,5-Diamino-cyclopent-2-enones
(CP) are
usually prepared by Lewis acid-catalyzed condensation of furfural
and a secondary amine in an organic solvent. The reaction proceeds
through the formation of a Stenhouse salt (SS) intermediate followed
by an electrocyclization reaction to afford the desired CP. Herein,
we described the use of CuÂ(OTf)<sub>2</sub> as a very efficient catalyst
for the synthesis of CP in water at room temperature. Furthermore,
the mild reaction conditions, catalyst reusability, and outstanding
functional group tolerance suggest that this CP platform can be further
used in chemical biology