DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF IGURATIMOD IN BULK AND PHARMACEUTICAL DOSAGE FORM

Objective: The objective of the work was to develop and validate stability indicating HPTLC method for the estimation of Iguratimod. Methods: The method employed HPTLC aluminium pre-covered silica gel 60 GF254 plates (10 cm × 10 cm with 250 μm layer thickness) as stationary phase while the solvent system was n-Hexane: Ethyl Acetate (5:5 v/v) with densitometric scanning at 256 nm. Sample was applied as a band of 8 mm width using Camag 100 μl sample syringe (Hamilton, Switzerland) using a linomat 5 applicator (Camag, Switzerland). Migration distance was 80 mm. Further the sample was subjected for stress conditions under acid and base hydrolysis, oxidation, thermal, neutral and photolytic conditions. Method validation done according to ICH Q2 (R1) guidelines. Results: Retention factor (Rf) of the drug was 0.41±0.02. The linearity of the method was found to be within the concentration range of 200-1200 ng/band with R2= 0.983. Limit of detection and limit of quantification were found to be 34.69 and 105.12 ng/band respectively. The % mean recovery was found to be 100.38±0.83. Stress results showed that there is degradation in acid and base conditions but two degradant peaks were observed only under alkaline stress condition Conclusion: The developed method found to be accurate, simple and precise. Method is successfully employed for quantification of the drug under various stress conditions

Impact and Usage of Social Media in Business Sector during Covid-19 Pandemic

The Impact of covid-19 faced by whole world. The economic growth of all the countries is going down because of covid-19. In India, the covid-19 affected all the sectors but it mostly affected business sector. Social media is used in business sector, but during covid-19 pandemic situation social media is widely used in business sector for work effectively. The purpose of study is to determine the impact of social media on startup and growing business. The researcher wish to investigate how social Media influence on the growth of business and also to analyze which social media tools and application are used for effective work of business. Experiment were done on research data collected from the internet, Journal, Articles and personal prior knowledge. The result showed business sector are work or run effectively during pandemic situation. Most of business are used social media platform for example- Facebook, twitter, Instagram LinkedIn etc. Business sector are use social media platform for improving business both in quality and quantity. So, we conclude that, Business sector widely used social Media platform for effective and continuous work. This study is significant for Business Entrepreneur, Society, stakeholders, Government people and competitors. &nbsp