Incidence and geographic distribution of extensively drug-resistant tuberculosis in KwaZulu-Natal Province, South Africa

South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drugresistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/ 100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence.This work was supported by: R01 AI089349, National Institutes of Health, NRG NSS (http://www.nih.gov/); 2007071, Doris Duke Charitable Foundation Clinical Scientist Development Award, NSS (http://www.ddcf.org/); 2007070, Doris Duke Charitable Foundation Clinical Scientist Development Award, NRG (http://www.ddcf.org/); K24 114444, K24 Career Development Award from the National Institute of Allergy and Infectious Diseases, NRG (http://www.niaid.nih.gov/Pages/default.aspx); P30 AI050409, Emory University Center for AIDS Research, NRG (http://www.cfar.emory.edu/); K23 AI083088, National Institutes of Health, JCMB (http:// www.nih.gov/); and P30 AI051519, Einstein- Montefiore Center for AIDS Research, JCMB (http:// www.einstein.yu.edu/centers/center-for-aidsresearch/).http://www.plosone.orgam201

High Prevalence of Candida auris Colonization during Protracted Neonatal Unit Outbreak, South Africa

One third of patients were colonized by Candida auris during a point-prevalence survey in a neonatal unit during an outbreak in South Africa. The sensitivity of a direct PCR for rapid colonization detection was 44% compared with culture. The infection incidence rate decreased by 85% after the survey and implementation of isolation/cohorting

Change in incidence of XDR-TB in KwaZulu-Natal province, South Africa, 2007 to 2010–12.

<p>Panel A shows the XDR-TB incidence (per 100,000 population) in each district in 2007. Panel B shows the average XDR-TB incidence by district in 2010–2012. The size of the circles is proportional to the incidence rate. The colors in panel B represents the change in incidence compared to 2007 data: red, increase; green, decrease.</p

Cases of XDR-TB in KwaZulu-Natal province, South Africa, October 2010-December 2012.

<p>*Statistics Soth Africa, 2012. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132076#pone.0132076.ref014" target="_blank">14</a>]</p><p>^†Moodley et al. PLOS ONE 011. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132076#pone.0132076.ref006" target="_blank">6</a>]</p><p>Cases of XDR-TB in KwaZulu-Natal province, South Africa, October 2010-December 2012.</p