15 research outputs found

    Additional file 1: of Millstone Exfoliation: a True Shear Exfoliation for Large-Size Few-Layer Graphene Oxide

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    Figure S1. SEM micrographs from MOG-30, MOG-60, MOG-90, and as-received graphite. Figure S2. TEM micrographs from MOG-30 and MOG-90. Figure S3. AFM micrographs from MOG-30 and MOG-90 (DOCX 2127 kb

    Additional file 1: Fig. S1. of The prognostic significance of KRAS and BRAF mutation status in Korean colorectal cancer patients

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    Kaplan-Meier curves for DFS and OS between KRAS mutation at codon 12 and 13. A. DFS between KRAS mutation at codon 12 and 13 and B. OS between KRAS mutation at codon 12 and 13. (PPTX 266 kb

    Additional file 1: of Extracellular vesicle-derived DNA for performing EGFR genotyping of NSCLC patients

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    Materials and methods. Table S1. Patient demographics and clinical characteristics. Table S2. Concentration and purity (260/280) of BALF EV DNA and BALF cfDNA. Table S3. Concentration of DNA larger than 1kb in EV DNA and cfDNA. Table S4. Ct value of EV DNA and cfDNA samples and their differences. Table S5. Comparison of the EGFR mutation status between tumor tissue and plasma in EGFR-TKIs naïve patients. Table S6. Clinical characteristics of patients who developed acquired resistance to 1st or 2nd generation EGFR-TKIs and underwent rebiopsy. Figure S1. Sizes of purified BALF EVs. Figure S2. Sizes of purified plasma EVs. Figure S3. EM image of BALF EVs. Figure S4. Immuno-EM images show detection of dsDNA in BALF EVs. Red arrows indicate gold particles. Figure S5. Gel-like images show the size and amount of EV DNA and cfDNA determined using the bioanalyzer. (DOCX 900 kb

    Additional file 1: Figure S1. of Low-FODMAP formula improves diarrhea and nutritional status in hospitalized patients receiving enteral nutrition: a randomized, multicenter, double-blind clinical trial

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    Improvement (%) of constipation and recurrent diarrhea/constipation according to EN types during the intervention. Table S1. Baseline distribution of major gastrointestinal intolerance in the study subjects. Table S2. Biochemical markers of nutritional status, lipid profiles, and inflammation, before and after the intervention. Table S3. Proportion of the low-, moderate-, and high-FODMAP EN consumption according to the subjects’ condition. (DOCX 488 kb

    Additional file 1: of Neoadjuvant radiotherapy of early-stage breast cancer and long-term disease-free survival

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    Relative survival and bootstrap analyses. Relative survival for ER-positive patients who underwent partial mastectomy (stratified by radiation sequencing) and bootstrap analyses for neoadjuvant and adjuvant RT cohorts matched for size and year of diagnosis. (DOCX 749 kb

    Identification of genome-wide targets of Olig2 in the adult mouse spinal cord using ChIP-Seq

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    <div><p>In jawed vertebrates, oligodendrocytes (OLs) are the myelin-producing glial cells responsible for ensheathment of axons within the central nervous system and are also crucial for remyelination following injury or disease. Olig2 is a crucial factor in the specification and differentiation of oligodendrocyte precursor cells (OPCs) that give rise to mature, myelin-producing OLs in the developing and postnatal CNS; however, its role in adulthood is less well understood. To investigate the role Olig2 plays in regulating gene expression in the adult OL lineage in a physiologically-relevant context, we performed chromatin immunoprecipitation followed by next generation sequencing analysis (ChIP-Seq) using whole spinal cord tissue harvested from adult mice.</p><p>We found that many of the Olig2-bound sites were associated with genes with biological processes corresponding to OL differentiation (Nkx2.2, Nkx6.2, and Sip1), myelination and ensheathment (Mbp, Cldn11, and Mobp), as well as cell cycle and cytoskeletal regulation. This suggests Olig2 continues to play a critical role in processes related to OL differentiation and myelination well into adulthood.</p></div

    Functional GO terms overrepresented in the Olig2 ChIP-Seq dataset.

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    <p>Shown are the highest ranking terms for (A) Biological Processes, (B) Protein Class, and (C) Pathways according to PANTHER (geneontology.org) and ranked according enrichment score (FE; red bars) and statistical significance (-log2p-val; black line) as indicated.</p
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