Incidence of Behçet’s disease by sex and age group from 2013 to 2014.

<p>Incidence of Behçet’s disease by sex and age group from 2013 to 2014.</p

Baseline characteristics of the study population.

<p>Baseline characteristics of the study population.</p

Flow chart of the study process.

<p>Flow chart of the study process.</p

Overall colonoscopic outcomes of fellowship trainees.

<p>Overall colonoscopic outcomes of fellowship trainees.</p

Factors associated with higher adenoma detection rate in the last half of the year^a.

<p>Factors associated with higher adenoma detection rate in the last half of the year<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0164360#t003fn001" target="_blank">^a</a>.</p

Comparison of colonoscopic quality indicators of fellowship trainees between the first half of the year and last half of the year.

<p>Comparison of colonoscopic quality indicators of fellowship trainees between the first half of the year and last half of the year.</p

Comparison of outcome variation over time between pre-trained and not pre-trained groups.

<p>Comparison of outcome variation over time between pre-trained and not pre-trained groups.</p

Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence

<div><p>Background and aim</p><p>High heart rate is an independent predictor of total cancer incidence and all-cause mortality in patients with cancer. We aimed to evaluate the impact of resting heart rate on the recurrence of colorectal polyp, using long-term surveillance follow-up data of colorectal cancer survivors.</p><p>Methods</p><p>Three hundred patients were selected from the colorectal cancer survivor cohort of Severance Hospital, Seoul, Korea. Resting heart rate, physical activity, and body composition analysis at the time of 5-year survival, and clinical data including colonoscopy surveillance results were collected for mean follow-up duration of 8 years.</p><p>Results</p><p>Patients with a high resting heart rate showed a significantly higher recurrence rate of advanced adenoma than those with a low resting heart rate (quartile 1, 45–66 beats per minute (b.p.m.); quartile 2, 67–73 b.p.m.; quartile 3, 74–80 b.p.m.; quartile 4, 81–120 b.p.m.; 3.8% vs. 7.9% vs. 10.0% vs. 14.7%, <i>p</i> for trend = 0.018). After adjustment for various risk factors, patients in the highest quartile of resting heart rate (≥ 81 b.p.m.) had a significantly higher risk of advanced adenoma recurrence (hazard ratio [HR]: 6.183, 95% confidence interval [CI]: 1.181–32.373, <i>p</i> = 0.031), compared to those in the lowest quartile (≤ 66 b.p.m.). In subgroup analysis, the association of resting heart rate with advanced adenoma recurrence appeared to be stronger among patients who had more than normal body fat mass or sedentary life style.</p><p>Conclusions</p><p>Elevated resting heart rate was independently associated with a higher rate of advanced adenoma recurrence in colorectal cancer survivors.</p></div

Colorectal polyp recurrence rates according to resting heart rates.

<p>Colorectal polyp recurrence rates according to resting heart rates.</p

Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence - Fig 1

<p>Kaplan-Meier analysis (log-rank tests) to compare the cumulative rate of development of advanced adenoma between low resting heart rate group (quartile 1 and 2, < 74 b.p.m.) and high resting heart rate group (quartile 3 and 4, ≥ 74 b.p.m.) (A), and between high resting heart rate group (≥ 70 b.p.m.) and low resting heart rate group (< 70 b.p.m.) (B).</p