The Harlem Renaissance\u27s Hidden Figure

This project will seek to look at the Harlem Renaissance’s hidden figure, Jessie Fauset. Jessie Fauset was born to an A.M.E. minister and his wife as one of ten children in Camden County New Jersey and raised in Philadelphia. From there she got her college degree and began teaching all over the country. She has written four novels, There is Confusion, Plum Bun, The Chinaberry Tree, and Comedy: American Style, all of which I have read this summer. Each novel focuses on the early twentieth century black family. I will be analyzing these novels under the four themes of passing, acceptance, romance, and Paris/escape. I will also be mapping the characters in the novel on a QGIS system in order to indicate where the majority of the novel takes place and to see if certain characters have more movement than others. I will finally map Jessie Fauset’s life in order to see if her life parallels with the lives of her characters. Mapping consists of a close reading of the novel, identifying locations in the book, creating an excel spreadsheet, and plotting the spreadsheet onto an online map on QGIS

Violent or Non-Violent? What Difference Does it Make in 1960’s Civil Rights Activism and the State?

In this essay, I research the differences between violent and non-violent actors during the civil rights movement and how their methods changed their interactions with the state. For my case study, I chose two violent and two non-violent subjects, as well as two individuals, and two organizations. Those being Martin Luther King Jr. and the Student Nonviolent Coordinating Committee for my nonviolent actors, and Malcolm X and The Black Panther Party as my violent actors. I examine how their methods as individuals and groups changed the way they interacted with Police, The FBI, and the Federal Government such as presidents and congress

Racial Experience as an Alternative Operationalization of Race

The study of human variation is central to both social and biomedical sciences; however, despite agreeing that variation is integral to the human experience, social and biomedical scientists diverge in how variation is theorized and operationalized. Race becomes especially problematic because it is a cultural concept that contains implicit and explicit understandings of how collective bodies differ. In this paper, we propose an operationalization of race that is attentive to both racial experience and human biological diversity—placing them within the same ontological sphere. Furthermore, we argue that this approach can more effectively advance antiracist pedagogy and politics. We argue that human biological diversity does not have to be in opposition to constructivist notions of race. Rather, racial experience is emphasized as an embodied experience that is as real and as valid as biological variation. By focusing on both racial experience and biological diversity, it becomes more feasible to operationalize race and to more fruitfully inform the pedagogy and politics of anti-racism. In such an operationalization, racial experience must be more broadly conceived, that is, it should not always equate to negative outcomes. With the recognition that racial experience has the potential to be something other than damaging, an antiracist anthropology can more effectively address issues pertaining to racial health disparities

A clinical study on reconstruction of traumatic auricular defects

The auricle or external ear is an important aesthetic subunit of the face. The intricate anatomy due to multiple convolutions along with the thin integument poses a challenge to the reconstructive surgeon. The prominent position of the ear on either side of the face and over a bony prominence makes it more prone for injury. The objective of the study is to describe various traumatic auricular defects and their subsequent reconstructive methods. A retrospective analysis of 15 patients with traumatic auricular defects was carried out over a period of 2 years between the time period of January 2022 and December 2023. Various reconstructive methods such as Primary closure, use of chondral grafts and chondrocutaneous flaps, local flaps were employed depending on the size of the defect and according to the reconstructive ladder. Out of 15 patients, 12 were male and 3 were female, with traumatic ear defects secondary to road traffic accidents (12) and human bite (3). The site of the defect was upper 1/3d (8), upper+middle 1/3rd (3), lower+middle third (2), middle third (1) and lower 1/3rd (1) of the auricle. They were managed by debridement and primary closure in 5 cases, post auricular flap in 5 cases, preauricular flap in 2 cases, peninsular conchal island flap+postauricular flap in 1 case, and bilobed flap in 1 case. All the flaps settled well. 4 patients needed secondary procedures in the form of flap division and contour corrections. This study employed a variety of reconstruction methods of the auricle as per the reconstructive ladder. Some of the patients required secondary procedures. All patients in this study had a satisfactory end aesthetic outcome with no major complications

Soil Fertility Management, a Tool for Sustainable Disease and Weed Control in Sub-Saharan Africa: A Review

Agro-ecosystem health is built on habitat manipulation and fertility enhancement. Similarly, plant nutrient levels altered by fertilization practices can expose crop plants to pests. In addition, diseases, weeds and other pests are principal agricultural losses all over the world. This is particularly devastating particularly in the developing nations of Sub-Saharan Africa, especially Nigeria. Reduction in these losses will not only improve agricultural production but will enhance food security and economic well-being of society. Sole use of synthetic chemicals is economically not a viable option and does not encourage environmental sustainability while land expansion is equally elusive due to urbanization and different forms of development and not environmentally friendly. The most viable and practicable option is integration of different fertility management alternatives that could produce crops on a sustainable bases while ensuring the safety and sustainability of the environment. Integrated Soil fertility Management (ISFM) has proved to be a promising approach to fertility management and sustainable environment. It could be adopted as it provides the needed nutrients for plants, reduce weeds and disease incidences while safeguarding the environment

Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice

This is the publisher's version, also available electronically from "http://www.jneurosci.org".The microtubule-associated protein tau is highly soluble under physiological conditions. However, in tauopathies, tau protein aggregates into insoluble filaments and neurofibrillary tangles (NFTs). The mechanisms underlying the formation of tau filaments and NFTs in tauopathies remain unclear. Several lines of evidence suggest that transglutaminase may cross-link tau into stable, insoluble aggregates, leading to the formation of NFTs in Alzheimer's disease and progressive supranuclear palsy. To further determine the contribution of transglutaminase in the formation of NFTs, we compared the levels of cross-linked tau protein from P301L tau transgenic mice that develop NFTs to four-repeat wild-type (4RWT) tau transgenic and nontransgenic mice that do not develop NFT pathology. Immunoprecipitation and immunoblotting experiments show that transglutaminase cross-links phosphorylated tau in the hindbrain of P301L tau transgenic mice but not in mice overexpressing 4RWT tau and nontransgenic mice. Cross-linked, phosphorylated tau from P301L tau transgenic mice runs as high-molecular mass aggregates on Western blots, similar to cross-linked tau from paired helical filaments of Alzheimer's disease. We also used double-label immunofluorescence to demonstrate colocalization of PHF-1-immunoreactive tau and the transglutaminase-catalyzed cross-link in the hindbrain, spinal cord, and cortex of P301L tau transgenic mice. In the spinal cord, 87% of PHF-1-labeled cells colocalize with the transglutaminase-catalyzed cross-link. Additionally, transglutaminase enzymatic activity is significantly elevated in the spinal cord of P301L tau transgenic mice. These studies further implicate transglutaminase in the formation and/or stabilization of NFT and paired helical filaments and provide a model system to investigate the therapeutic potential of transglutaminase inhibitors in tauopathies

Ultrasound Orientation Sensor

Ultrasound (US) is a painless method of gaining a visual representation of the internal structures of a human body. It is used to look for diseases and other abnormalities. In effort to minimize and eliminate the amount of error generated by the operation of an US machine, a team of WPI students conducted research into the causes and reasons as to why these problems are not resolved. Ultimately, the team approached the problem through the use of an inertial measurement unit (IMU), and the development of a graphical user interface to track the orientation of an US probe. The results supported that feedback regarding probe orientation can increase the ability to reproduce ultrasound images

Modulation of the Fanconi anemia pathway \u3ci\u3evia\u3c/i\u3e chemically induced changes in chromatin structure

Fanconi anemia (FA) is a rare disease characterized by congenital defects, bone marrow failure, and atypically early-onset cancers. The FA proteins function cooperatively to repair DNA interstrand crosslinks. A major step in the activation of the pathway is the monoubiquitination of the FANCD2 and FANCI proteins, and their recruitment to chromatin-associated nuclear foci. The regulation and function of FANCD2 and FANCI, however, is poorly understood. In addition, how chromatin state impacts pathway activation is also unknown. In this study, we have examined the influence of chromatin state on the activation of the FA pathway. We describe potent activation of FANCD2 and FANCI monoubiquitination and nuclear foci formation following treatment of cells with the histone methyltransferase inhibitor BRD4770. BRD4770-induced activation of the pathway does not occur via the direct induction of DNA damage or via the inhibition of the G9a histone methyltransferase, a mechanism previously proposed for this molecule. Instead, we show that BRD4770-inducible FANCD2 and FANCI monoubiquitination and nuclear foci formation may be a consequence of inhibition of the PRC2/EZH2 chromatin-modifying complex. In addition, we show that inhibition of the class I and II histone deacetylases leads to attenuated FANCD2 and FANCI monoubiquitination and nuclear foci formation. Our studies establish that chromatin state is a major determinant of the activation of the FA pathway and suggest an important role for the PRC2/EZH2 complex in the regulation of this critical tumor suppressor pathway

The Grizzly, March 23, 2017

Immigration Panel Will Allow Students to Express Their Experience with Political Issues • International Perspective: Reflections on Adjusting to Campus Culture in the Fall • Important Housing Lottery Dates and Advice from Residence Life • Tech Support Updates Outdated Login Service • From Taxes to Spaghetti, Nerd Camp Helps Students Navigate the Real World • First-Person Perspective: Student Reflects on Class Trip to Chicago • Opinions: Does U.S. Happiness Affect UC Happiness?; Trappe Beer and Soda or Austin\u27s Beverages? • From Amateur Wrestler to College Professor: Nick Scoville Does it All • Fun in the Sun: Five Ursinus Teams Traveled Cross Country to Compete During Spring Breakhttps://digitalcommons.ursinus.edu/grizzlynews/1663/thumbnail.jp