New Diagnostic Real-Time PCR for Specific Detection of Mycoplasma hominis DNA

Mycoplasma hominis is a fastidious micro-organism causing genital and extragenital infections. We developed a specific real-time PCR that exhibits high sensitivity and low intrarun and interrun variabilities. When applied to clinical samples, this quantitative PCR allowed to confirm the role of M. hominis in three patients with severe extragenital infections

Streptococcus sinensis Endocarditis outside Hong Kong

Streptococcus sinensis has been described as a causative organism for infective endocarditis in 3 Chinese patients from Hong Kong. We describe a closely related strain in an Italian patient with chronic rheumatic heart disease. The case illustrates that S. sinensis is a worldwide emerging pathogen

Prevalence and Associated Factors for Chlamydia trachomatis Infection Among Undocumented Immigrants in a Primary Care Facility in Geneva, Switzerland: A Cross-Sectional Study

Chlamydia trachomatis infection (CTI) is the most frequent sexually transmitted infection in western countries. Its prevalence in undocumented immigrants, a rapidly growing vulnerable population, remains unknown. We aimed to document the prevalence of CTI and associated factors at the primary health care level. This cross-sectional study included all undocumented immigrants attending a health care facility in Geneva, Switzerland. Participants completed a questionnaire and were tested for CTI by PCR assay. Three-hundred thirteen undocumented immigrants (68.4% female, mean age 32.4 (SD 8) years) agreed to participate. CTI prevalence was 5.8% (95% CI 3.3-8.4). Factors associated with higher prevalence were age ≤25 (OR 3.9, 95% CI 1.3-12.2) and having had two or more sexual partners during the precedent year (OR 4.5, 95% CI 1.5-13.7). Prevalence and associated factors for infection in this vulnerable population were comparable with other populations in Western countries. Our findings support the importance of facilitating access to existing screening opportunities in particular to individuals at higher ris

Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines

Community-acquired pneumonia (CAP) is a major cause of death in developing countries and of morbidity in developed countries. The objective of the study was to define the causative agents among children hospitalized for CAP defined by WHO guidelines and to correlate etiology with clinical severity and surrogate markers. Investigations included an extensive etiological workup. A potential causative agent was detected in 86% of the 99 enrolled patients, with evidence of bacterial (53%), viral (67%), and mixed (33%) infections. Streptococcus pneumoniae was accounted for in 46% of CAP. Dehydration was the only clinical sign associated with bacterial pneumonia. CRP and PCT were significantly higher in bacterial infections. Increasing the number of diagnostic tests identifies potential causes of CAP in up to 86% of children, indicating a high prevalence of viruses and frequent co-infections. The high proportion of pneumococcal infections re-emphasizes the importance of pneumococcal immunizatio

Chapitre 5. L’ISR 2.0 : plus qu’un relookage, une authentique refondation

La gravité des crises financières à répétition et les défis associés à la durabilité au plan mondial créent une vraie urgence pour la finance responsable. Malgré l’intérêt des investisseurs institutionnels, l’ISR est loin de devenir la norme et il a rencontré un succès très limité avec des investisseurs privés et des réseaux de distribution. Notre hypothèse est que cet échec découle d’une série de malentendus profonds, à propos du couple ISR / RSE, entre les différents acteurs, à savoir les entreprises « responsables », qui sont des praticiens de la RSE, les académiques, les sociétés de gestion et professionnels de la finance ISR, les agences de notation extra-financière et les analystes.Pour réconcilier vraiment la finance et de la durabilité, nous devons d’abord dépasser le dilemme classique entre l’éthique et la performance, qui considère les critères non-financiers comme une contrainte sévère et favoriser une conception contributive de la prospérité durable, pour les agents publics comme privés.Ce chapitre présente une approche « bottom-up » qui réintroduit l’horizon de long terme dans les décisions d’investissement et se concentre sur les capacités d’adaptabilité et d’innovation des entreprises (et des États) devant des défis sans précédent du siècle qui démarre.The severity of the repeated financial crises and the challenges associated with global sustainability call urgently for responsible finance. Despite praise from institutional investors, SRI is far from the norm and has met very limited success with private investors and retail networks.Our hypothesis is that this failure stems from a series of profound misunderstandings about CSR and SRI among the various stakeholders, i. e. “responsible” companies that are practitioners of CSR, academic theorists, asset management companies, SRI finance professionals, rating agencies and non-financial analysts.To truly reconcile finance and sustainability we first need to go beyond the traditional dilemma between ethics and performance which considers any non-financial criteria as a severe constraint and foster a contributive conception of sustainable prosperity, for public and private agent as well.This chapter thus presents a “bottom-up” approach that reintroduces the long-term horizon in investment decisions and focus on the adaptability and innovation capacities of the firms (and States) in front of the unprecedented challenges of the century

Introduction [au cahier « Finance & Société ». L’investissement d’impact]

International audienc

Dix ans après la chute de Lehman…: Pour un nouveau logiciel financier à l’ère de l’anthropocène

International audienceTen years after the crisis, the financial sphere has rebuilt confidence, but the carbon growth model has continued to grow along with the demographic boom and the rising standards of living. Whereas the ecological risk is still missing in the economic prospective, the next correction won’t stem from the banking system but from the inescapable entry of the economic-financial sphere into the Anthropocene era.Dix ans après la crise la sphère financière s’est rassurée sur sa solidité. Si peu a été entrepris pour s’attaquer aux causes économiques du phénomène, le modèle de croissance carbonée a continué à progresser avec l’accroissement démographique et l’élévation du niveau de vie. Le risque écologique reste absent de la prospective économique. La prochaine correction ne sera pas d’origine bancaire mais fruit de l’inévitable entrée de la sphère économico-financière dans l’ère de l’anthropocène

Apport de la biopsie ostéomédullaire dans le diagnostic des fièvres prolongées inexpliquées et des syndromes inflammatoires biologiques persistants de l'adulte (à propos de 180 observations vues en médecine interne)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Risque thrombotique lors des thrombopénies immunologiques en présence d'anticorps antiphospholipides

LYON1-BU Santé (693882101) / SudocSudocFranceF