Gisements naturels Pléistocenes et Holocènes des cavités des Pyrénées Occidentales Françaises: Inventaire et datages 14C.

Recientes descubrimientos fortuitos de espeleólogos permiten completar los datos proporcionados por los yacimientos paleontológicos clásicos. Se redacta un primer inventario de las cavidades de los Pirineos Atlánticos y de los Altos Pirineos franceses, donde han caído animales salvajes accidentalmente, sea en simas verticales o sea a lo largo de fuertes pendientes. Se da cuenta de dataciones 14 C sobre algunos de estos restos

Immunological Aspects of Psoriasis: V.T. Cell Subsets and Suppressor Cell Functions Regulating Immune Responses in Peripheral Blood

T cell subsets bearing Fc-receptors for either IgG (TG) or IgM (TM), and suppressor cell activity of peripheral blood mononuclear cells on in vitro lymphoproliferative response were studied in patients with untreated psoriasis. The proportions of TG and TM cells were unmodified in 15 patients compared to 15 control subjects studied in parallel experiments. The concanavalin A-induced suppressor cell activity, as well as the spontaneous suppressor cell function of in vitro short-lived adherent cells, were in the normal range for 7 out of 8 psoriatic patients investigated. The data argue against the possibility that a generalized suppressor cell defect occurs in psoriasis

Response to Treatment and Disease Progression Linked to CD4+ T Cell Surface CC Chemokine Receptor 5 Density in Human Immunodeficiency Virus Type 1 Vertical Infection

The factors governing interindividual variability in disease progression among children vertically infected with human immunodeficiency virus type 1 (HIV-1) remain unclear. Because it has recently been shown in infected adults that the density of CC chemokine receptor 5 (CCR5) molecules at the surface of nonactivated (human leukocyte antigen [HLA]-DR-) CD4+ T cells correlates with disease progression, the same correlation was sought in children. HLA-DR-CD4+ T cell surface CCR5 density was constant over time and correlated with the bioclinical stage and with the CD4 cell slope observed before antiretroviral treatment. In addition, CCR5 density was negatively correlated with the intensity of the decrease in viremia during antiretroviral therapy and was positively correlated with CD4 cell slope since birth. These results are compatible with the hypothesis that CCR5 density is a key factor governing disease progression in pediatric HIV-1 infection and, thereby, an indicator of prognosis. Moreover, they suggest that therapies aimed at reducing CCR5 accessibility should slow down HIV disease evolution in childre

Premiers datages radiocarbone du Magdalénien des Hautes-Pyrénées

Résumé — Les gisements magdaléniens, classiques ou inédits, des Hautes-Pyrénées sont inventoriés. Des travaux récents dans les grottes d'Espèche et des Espélugues ont fourni un matériel qui a pu être daté par C. 14. Des restes osseux des grottes d'Aurensan et de Labastide, fouillées anciennement, ont permis trois dates complémentaires. Ces datages mettent en évidence deux groupes, dont le plus ancien peut être rattaché au Magdalénien moyen.Clot André, Omnès Jacques. Premiers datages radiocarbone du Magdalénien des Hautes-Pyrénées. In: Bulletin de la Société préhistorique française, tome 76, n°10-12, 1979. Études et Travaux. pp. 324-339

Anomalies de l'immunité associées à une intoxication alcoolique chronique

MONTPELLIER-BU Médecine UPM (341722108) / SudocPARIS-BIUP (751062107) / SudocMONTPELLIER-BU Médecine (341722104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Travail, identités, métier : quelles métamorphoses ?

Colloque international organisé au Collège de France les 23, 24 et 25 juin 2009 par la chaire de Physiologie de la perception et de l’action (Pr Alain Berthoz) en collaboration avec la chaire de Psychologie du travail du Conservatoire national des arts et métiers (Pr Yves Clot

Intracytoplasmic Th1 and Th2 cytokines in rheumatoid arthritis blood and synovial tissue

In rheumatoid arthritis (RA), T cells have been proposed either as a main actor or as an epiphenomenon in such a primarily synoviocyte-driven disease. A major issue remains the remarkable paradox between the T cell infiltrate and the relative failure to detect definite markers of their activity. To determine the Th1/Th2 cytokine profile in RA synovium, we used a single cell flow cytometric assay for interleukin-2 (IL-2), interferon-γ (FN-γ), IL-4 and IL-10 in paired peripheral blood (PB) and synovial tissue (ST) lymphocytes from RA and osteoarthritis (OA) patients and PB lymphocytes from healthy controls. Cytokines were undetectable in unstimulated PB and ST lymphocytes. More stimulated PB arm ST CD4+ lymphocytes produced IFN-γ than IL-4, for all individuals tested. RA PB CD4+ lymphocytes showed the same Th1 cytokine pattern as normal controls. No increase of such a Th1 profile was observed for ST lymphocytes. A specific recruitment of T CD4+ lymphocytes in the rheumatoid inflamed synovium could not be concluded on the basis of these results