Pathologies associées à des anomalies de la régulation post-transcriptionnelle

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

A propos de neuf cas de thrombocytopénies induites par les héparines

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

Le marché de la thrombose veineuse profonde (analyse et stratégie d'une héparine de bas poids moléculaire)

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

Deprotonation-alkylation of alkyl cyanides under sonochemical conditions

International audienceDeprotonation-alkylation of n-alkyl cyanides can be readily effected by an alkyl halide in the presence of sodium in a one pot procedure. Yields are generally better than in the usual methods, and the overall reaction conditions have important advantages in terms of ease and simplicity compatible with preparative scale-up

Déficits en facteur XI (aspects théoriques et pratiques)

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

New process for the synthesis of the 2-propyl pentane nitrile under ultrasonic irradiation

International audienceThe synthesis of 2-propyl pentane nitrile (DPAN) is a key step in the synthesis of a drug (valproic acid). The usual process is based on sodium-amide-mediated alkylation of valeronitrile. We describe a possible new process, which makes use of metallic sodium. The reaction has been carried out with ultrasound and the results compared with those obtained under “silent” conditions with different stirring systems. Under sonication, a several percentage improvement of the chemical yield and selectivity, and a low rate increase are observed. The optimum temperature (about 25 °C) and sodium particle size (about 2 mm) have been determined

Regards croisés sur la langue française : usages, pratiques, histoire

Ce livre rassemble des contributions de chercheurs internationaux qui réfléchissent sur les relations entre langue, discours et société. Il s’adresse à un public diversifié, spécialistes ou étudiants, intéressé aussi bien par l’histoire de la langue française que par la sociolinguistique, l’analyse du discours et la didactique du français. Dans un premier temps, est abordée la complexe et tumultueuse histoire de « la langue commune ». On y présente plusieurs approches théoriques du changement des usages à travers des études de cas, en diachronie et en synchronie. La deuxième partie réunit des articles qui relèvent de l’analyse du discours. Enfin, une section est consacrée à l’évolution de l’enseignement du français à l’école primaire ainsi qu’aux diverses pratiques pédagogiques passées et actuelles. Cet ouvrage est un hommage à Sonia Branca-Rosoff, dont la recherche a su articuler rigoureusement ces divers domaines

Characterization of beta(3)-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management

ObjectivesThe aim of the present study was to analyze whether beta3-adrenoceptors (β3-ARs) were effectively present and functional in the human internal mammary artery (IMA).BackgroundThe beta1- and beta2-adrenoceptors classically mediate the relaxant effects of catecholamines in the vessels. In vitro and in vivo studies performed in various animal species described vasodilating effects due to activation of a third beta-ARs subtype (β3).MethodsReverse transcription-polymerase chain reaction analysis, Western blot experiments, and pharmacological studies were carried out in human IMA samples harvested from 27 patients undergoing coronary bypass surgery.ResultsThe β3-ARs messenger ribonucleic acid and protein were detected in intact IMA, but were absent in endothelium-free samples. This finding was confirmed by immunohistochemical experiments. In organ baths, a β3-AR agonist, SR 58611A, induced an endothelium-dependent relaxation of phenylephrine-precontracted IMA rings. This vasodilation was not modified by β1/β2-AR antagonists, but was greatly altered in the presence of L-748,337, a selective human β3-AR antagonist. Moreover, the inhibition of nitric oxide (NO) synthases abolished the β3-adrenergic vasodilation, suggesting the involvement of a NO-signaling pathway.ConclusionsThose results demonstrated the presence of β3-ARs in the endothelial layer of human IMA. The present work highlights the role of β3-ARs in vasomotor control of IMA and opens new fields of investigation in coronary bypass graft management, heart failure, and hypertension