Deterministic Intracellular Modeling

The United States Air Force is interested in the potential side effects at the cellular level from exposure to mission-essential chemicals. Presently, Air Force toxicology studies are conducted to help shed light in identifying potential hazards to workers. However, it takes a considerable amount of money, resources, and time to obtain and analyze experimental results from toxicology studies. The necessity for innovative methods that enable researchers to more effectively generate and analyze data is apparent

International Migration, Population Change and the Labour Force, 1991-1996: An Overview

Between March 1991 and March 1996 the de facto population of New Zealand increased by around 225,000, the largest intercensal increase since the early 1970s. A short-lived surge in levels of natural increase in the early 1990s, coupled with some of the highest annual net migration gains since 1975, account for this substantial population growth. While there has been considerable comment in the media about the impact of this growth on the Auckland region in particular, the impacts which it has had on New Zealand's Labour force are less well known. This paper examines the components of change in labour force age groups between 1991 and 1996, isolating the impacts of immigration from those of structural change. The contrasting contributions to particular labour force age groups made by emigration of New Zealanders on the one hand, and immigration of citizens from other countries on the other, are then discussed. It is clear from the analysis that emigration and immigration are impacting quite differentially on the younger and older workforces. Some of the implications of these changes are explored with reference to the ageing labour force

Taming the Wilde: Collaborating with Expertise for Faster, Better, Smarter Collection Analysis

The importance of collection assessment and evaluation has been a hot topic due to increasing budget restrictions and the need to prove worth to stakeholders through evidence‐based evaluations. More robust collection analyses, like comparisons of holdings usage to ILL requests, and gap analyses, are increasingly embraced by the library community. Less thought, however, has been given to how to best conduct these analyses to ensure that the cleanest data is used and that the data tells the right story. The data to do these types of analyses often reside in complex systems and web‐environments, which may not be fully understood by the collection managers or subject librarians. The University of Houston Libraries embarked on a largescale gap analysis of the collection by subject area. The key component to success was quickly, accurately, and properly mining the data sources such as Sierra and the electronic resource management system. Our collection team contends that collaboration with expertise in the Resource Discovery Systems Department allowed the team to more quickly develop complete and accurate datasets, and helped to shape the analysis conducted. This paper discusses the challenges of defining project scope, the process of forming methodology, and the challenges of collecting the data. It will also review how experts were able to contribute to each step of this process. Finally it will outline some initial findings of the analysis, and how this research was accomplished in a realistic time frame

Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain

Mouse lines with behavioral phenotypes relevant to symptoms in neurodevelopmental disorders may provide models to test hypotheses about disease etiology and to evaluate potential treatments. The present studies were designed to confirm and expand earlier work on the intriguing behavioral profile of the C58/J inbred strain, including low social approach and aberrant repetitive movements. Additional tests were selected to reflect aspects of autism, a severe neurodevelopmental disorder characterized by emergence of symptoms early in life, higher prevalence in males, social deficits and abnormal repetitive behavior. Mice from the C57BL/6J inbred strain, which has a similar genetic lineage and physical appearance to C58/J, served as a comparison group. Our results revealed that C58/J mice display elevated activity levels by postnatal day 6, which persist into adulthood. Despite normal olfactory ability, young adult male C58/J mice showed deficits in social approach in the three-chambered choice assay and failed to demonstrate social transmission of food preference. In contrast, female C58/J mice performed similarly to female C57BL/6J mice in both social tests. C58/J mice of both sexes demonstrated abnormal repetitive behaviors, displaying excessive jumping and back flipping in both social and non-social situations. These stereotypies were clearly evident in C58/J pups by postnatal days 20–21, and were also observed in C58/J dams during a test for maternal behavior. Overall, the strain profile for C58/J, including spontaneously developing motor stereotypies emerging early in the developmental trajectory, and social deficits primarily in males, models multiple components of the autism phenotype

We know that our voices are valued, and that people are actually going to listen” : co-producing an evaluation of a young people’s research advisory group

Children and young people’s involvement is an increasing priority in healthcare and in heath research, alongside recognition that involving CYP in research requires different considerations to involving adults. Underpinned by children’s rights and a co-production ethos this poster and recorded presentation, from the 2023 Health Services Research UK conference, outlines the learning from a co-produced evaluation of eyeYPAG, a young persons’ research advisory group (YPAG) for eye and vision research based at Moorfields Eye Hospital, London.Peer reviewe

Attending a Demonstration School: Its Impact on Students\u27 Self-concept and School Motivation

Using mixed-methods, this study follows students as they transition from a two-year elementary demonstration school and are re-integrated into high school. This exploratory study examines the impact of assistive technology and the degree to which attending a demonstration school impacts students\u27 self-concept and school motivation

Regulation of signal transducers and activators of transcription (STATs) by effectors of adipogenesis: Coordinate regulation of STATs 1, 5A, and 5B with peroxisome proliferator-activated receptor-γ and C/AAAT enhancer binding protein-α

We have recently demonstrated that three signal transducers and activators of transcription (STAT) family members are induced during adipocyte differentiation (Stephens et al., J. Biol. Chem. 271 (1996) 10441- 10444). Since STATs 1, 5A, and 5B are induced during adipocyte differentiation, we have examined the ability of these proteins to be regulated by components of the differentiation cocktail. In addition, we have examined the effects of potent effectors of differentiation on STAT protein expression during adipogenesis. A negative effector, tumor necrosis factor-α (TNFα), and a positive effector, a thiazolidinedione, were used in these experiments. Our results demonstrate that the expression of STATs 1, 5A, and 5B is not dramatically influenced by individual components of the differentiation cocktail. However, the expression of these three STAT family members tightly correlates with lipid accumulation. Moreover, the expression of STATs 1, 5A, and 5B, but not STATs 3 and 6, are regulated in an identical fashion to both C/AAAT enhancer binding proteins α and peroxisome proliferator-activated receptor-γ by TNFα and a thiazolidinedione. Furthermore, the expression of adipocyte-expressed JAK kinases are unaffected by effectors of differentiation. These findings suggest that three STAT family members may play a role in the regulation of adipocyte gene expression