Characteristics of patients prescribed oral bisphosphonates compared with those prescribed only calcium and vitamin D.

<p>Characteristics of patients prescribed oral bisphosphonates compared with those prescribed only calcium and vitamin D.</p

Patient disposition.

<p>All patients with low trauma fractures were invited to attend the Fracture Liaison service clinics excluding those already on treatment, considered unsuitable for treatment and/or too frail and elderly and/or declined to attend. The data and analyses herein relate to those who attended and were fully assessed. Re-fx: Subsequent fracture.</p

Predictors of mortality.

<p>Multivariable Cox regression model; values are presented as hazard ratio’s (HR) with 95% confidence intervals (95%CI).</p

Predictors of subsequent fractures.

<p>Multivariable Cox regression model; values are presented as hazard ratios (HR) with 95% confidence intervals (95%CI).</p

Survival curves for subsequent fractures and mortality.

<p>The curves are based on multivariable Cox proportional hazard models for subsequent fractures and mortality expressed as (A) fracture-free probability and (B) cumulative survival. Results presented for vitamin D and calcium recommendation alone (dotted black) and for bisphosphonates plus calcium and vitamin D recommendation (solid grey).</p

Receiver Operating Characteristic (ROC) curves for model with BMD (continuous line) and model with weight (dashed line) for non-vertebral osteoporotic fracture (upper panel) and hip fracture (lower panel) in women and men based on (1A): 5-year predicted risk, and (1B): 10-year predicted risk.

<p>Receiver Operating Characteristic (ROC) curves for model with BMD (continuous line) and model with weight (dashed line) for non-vertebral osteoporotic fracture (upper panel) and hip fracture (lower panel) in women and men based on (1A): 5-year predicted risk, and (1B): 10-year predicted risk.</p

Concordance between the predicted and observed risk of non-vertebral osteoporotic fracture (upper panel) and hip fracture (lower panel) in the Tromsø Study cohort, according to the Garvan nomograms.

<p>(A): Quintile cut-offs for the predicted 10-year risk (%) of non-vertebral osteoporotic fracture in women were: 10.8, 15.3, 21.2 and 31.9 for model with BMD (M1); and 12.5, 16.3, 21.3 and 31.5 for model with weight (M2). Corresponding cut-offs in men were 5.3, 8.0, 11.7 and 18.3 for M1; and 5.9, 8.3, 12.1, 17.9 for M2. Quartile cut-offs for the predicted 10-year risk (%) of hip fracture in women were: 1.3, 2.6, 4.9 and 11.2 for M1 and 1.7, 2.9, 5.0 and 11.1 for M2; In men, 0.3, 0.8, 1.6 and 3.9 for M1; and 0.9, 1.5, 2.6 and 4.8 for M2. (B): Quintile cut-offs for the predicted 5-year risk (%) of non-vertebral osteoporotic fracture in women were: 5.2, 7.4, 10.5 and 16.4 for model with BMD (M1); and 6.2, 8.1, 10.8 and 16.5 for model with weight (M2). Corresponding cut-offs in men were 2.8, 4.2, 6.3 and 10.0 for M1; and 3.2, 4.5, 6.6, 10.1 for M2. Quartile cut-offs for the predicted 5-year risk (%) of hip fracture in women were: 0.7, 1.4, 2.7 and 5.8 for M1 and 0.9, 1.6, 2.8 and 6.3 for M2; In men, 0.2, 0.4, 0.8 and 2.1 for M1; and 0.5, 0.8, 1.4 and 2.7 for M2.</p

Baseline characteristics of women and men. The Tromsø Study.

<p>Values are mean (SD), unless otherwise specified.</p><p>* Compared with non-fracture group.</p><p>Baseline characteristics of women and men. The Tromsø Study.</p