1,908 research outputs found
On the Origin of Gravity and the Laws of Newton
Starting from first principles and general assumptions Newton's law of
gravitation is shown to arise naturally and unavoidably in a theory in which
space is emergent through a holographic scenario. Gravity is explained as an
entropic force caused by changes in the information associated with the
positions of material bodies. A relativistic generalization of the presented
arguments directly leads to the Einstein equations. When space is emergent even
Newton's law of inertia needs to be explained. The equivalence principle leads
us to conclude that it is actually this law of inertia whose origin is
entropic.Comment: 29 pages, 6 figure
The holographic principle
There is strong evidence that the area of any surface limits the information
content of adjacent spacetime regions, at 10^(69) bits per square meter. We
review the developments that have led to the recognition of this entropy bound,
placing special emphasis on the quantum properties of black holes. The
construction of light-sheets, which associate relevant spacetime regions to any
given surface, is discussed in detail. We explain how the bound is tested and
demonstrate its validity in a wide range of examples.
A universal relation between geometry and information is thus uncovered. It
has yet to be explained. The holographic principle asserts that its origin must
lie in the number of fundamental degrees of freedom involved in a unified
description of spacetime and matter. It must be manifest in an underlying
quantum theory of gravity. We survey some successes and challenges in
implementing the holographic principle.Comment: 52 pages, 10 figures, invited review for Rev. Mod. Phys; v2:
reference adde
The hidden horizon and black hole unitarity
We motivate through a detailed analysis of the Hawking radiation in a
Schwarzschild background a scheme in accordance with quantum unitarity. In this
scheme the semi-classical approximation of the unitary quantum - horizonless -
black hole S-matrix leads to the conventional description of the Hawking
radiation from a classical black hole endowed with an event horizon. Unitarity
is borne out by the detailed exclusive S-matrix amplitudes. There, the fixing
of generic out-states, in addition to the in-state, yields in asymptotic
Minkowski space-time saddle-point contributions which are dominated by
Planckian metric fluctuations when approaching the Schwarzschild radius. We
argue that these prevent the corresponding macroscopic "exclusive backgrounds"
to develop an event horizon. However, if no out-state is selected, a distinct
saddle-point geometry can be defined, in which Planckian fluctuations are
tamed. Such "inclusive background" presents an event horizon and constitutes a
coarse-grained average over the aforementioned exclusive ones. The classical
event horizon appears as a coarse-grained structure, sustaining the
thermodynamic significance of the Bekenstein-Hawking entropy. This is
reminiscent of the tentative fuzzball description of extremal black holes: the
role of microstates is played here by a complete set of out-states. Although
the computations of unitary amplitudes would require a detailed theory of
quantum gravity, the proposed scheme itself, which appeals to the metric
description of gravity only in the vicinity of stationary points, does not.Comment: 29 pages, 4 figures. Typos corrected. Two footnotes added (footnotes
3 and 5
Photoswitchable diacylglycerols enable optical control of protein kinase C.
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs, which feature a photoswitchable acyl chain. The PhoDAGs are inactive in the dark and promote the translocation of proteins that feature C1 domains toward the plasma membrane upon a flash of UV-A light. This effect is quickly reversed after the termination of photostimulation or by irradiation with blue light, permitting the generation of oscillation patterns. Both protein kinase C and Munc13 can thus be put under optical control. PhoDAGs control vesicle release in excitable cells, such as mouse pancreatic islets and hippocampal neurons, and modulate synaptic transmission in Caenorhabditis elegans. As such, the PhoDAGs afford an unprecedented degree of spatiotemporal control and are broadly applicable tools to study DAG signaling
Higher Curvature Gravity and the Holographic fluid dual to flat spacetime
Recent works have demonstrated that one can construct a (d+2) dimensional
solution of the vacuum Einstein equations that is dual to a (d+1) dimensional
fluid satisfying the incompressible Navier-Stokes equations. In one important
example, the fluid lives on a fixed timelike surface in the flat Rindler
spacetime associated with an accelerated observer. In this paper, we show that
the shear viscosity to entropy density ratio of the fluid takes the universal
value 1/4\pi in a wide class of higher curvature generalizations to Einstein
gravity. Unlike the fluid dual to asymptotically anti-de Sitter spacetimes,
here the choice of gravitational dynamics only affects the second order
transport coefficients. We explicitly calculate these in five-dimensional
Einstein-Gauss-Bonnet gravity and discuss the implications of our results.Comment: 13 pages; v2: modified abstract, added references; v3: added
clarifying comments, modified discussio
Fungal Melanins Differ in Planar Stacking Distances
Melanins are notoriously difficult to study because they are amorphous, insoluble and often associated with other biological materials. Consequently, there is a dearth of structural techniques to study this enigmatic pigment. Current models of melanin structure envision the stacking of planar structures. X ray diffraction has historically been used to deduce stacking parameters. In this study we used X ray diffraction to analyze melanins derived from Cryptococcus neoformans, Aspergillus niger, Wangiella dermatitides and Coprinus comatus. Analysis of melanin in melanized C. neoformans encapsulated cells was precluded by the fortuitous finding that the capsular polysaccharide had a diffraction spectrum that was similar to that of isolated melanin. The capsular polysaccharide spectrum was dominated by a broad non-Bragg feature consistent with origin from a repeating structural motif that may arise from inter-molecular interactions and/or possibly gel organization. Hence, we isolated melanin from each fungal species and compared diffraction parameters. The results show that the inferred stacking distances of fungal melanins differ from that reported for synthetic melanin and neuromelanin, occupying intermediate position between these other melanins. These results suggest that all melanins have a fundamental diffracting unit composed of planar graphitic assemblies that can differ in stacking distance. The stacking peak appears to be a distinguishing universal feature of melanins that may be of use in characterizing these enigmatic pigments
Radiation-induced malignancies following radiotherapy for breast cancer
With advances in diagnosis and treatment, breast cancer is becoming an increasingly survivable disease resulting in a large population of long-term survivors. Factors affecting the quality of life of such patients include the consequences of breast cancer treatment, which may have involved radiotherapy. In this study, we compare the incidence of second primary cancers in women who received breast radiotherapy with that in those who did not (non-radiotherapy). All women studied received surgery for their first breast cancer. Second cancers of the lung, colon, oesophagus and thyroid gland, malignant melanomas, myeloid leukaemias and second primary breast cancers were studied. Comparing radiotherapy and non-radiotherapy cohorts, elevated relative risks (RR) were observed for lung cancer at 10-14 years and 15 or more (15+) years after initial breast cancer diagnosis (RR 1.62, 95% confidence interval [CI] 1.05-2.54 and RR 1.49, 95% CI 1.05-2.14, respectively), and for myeloid leukaemia at 1-5 years (RR 2.99, 95% CI 1.13-9.33), for second breast cancer at 5-10 years (RR 1.34, 95% CI 1.10-1.63) and 15+ years (RR 1.26, 95% CI 1.00-1.59) and oesophageal cancer at 15+ years (RR 2.19, 95% CI 1.10-4.62)
Lorentz violation and Crab synchrotron emission: a new constraint far beyond the Planck scale
Special relativity asserts that physical phenomena appear the same for all
inertially moving observers. This symmetry, called Lorentz symmetry, relates
long wavelengths to short ones: if the symmetry is exact it implies that
spacetime must look the same at all length scales. Several approaches to
quantum gravity, however, suggest that there may be a Lorentz violating
microscopic structure of spacetime, for example discreteness,
non-commutativity, or extra dimensions. Here we determine a very strong
constraint on a type of Lorentz violation that produces a maximum electron
speed less than the speed of light. We use the observation of 100 MeV
synchrotron radiation from the Crab nebula to improve the previous limits by a
factor of 40 million, ruling out this type of Lorentz violation, and thereby
providing an important constraint on theories of quantum gravity.Comment: 12 pages. Presentation shortened and revised for letter to Nature.
New title "A strong astrophysical constraint on the violation of special
relativity by quantum gravity". Maximum observed synchrotron frequency
lowered, resulting in weakening the constraint from E_QG>4.5*10^27 GeV to
E_QG>10^26 GeV. The role of the effective field theory assumptions underlying
the analysis is highlighte
Stringy Stability of Charged Dilaton Black Holes with Flat Event Horizon
Electrically charged black holes with flat event horizon in anti-de Sitter
space have received much attention due to various applications in Anti-de
Sitter/Conformal Field Theory (AdS/CFT) correspondence, from modeling the
behavior of quark-gluon plasma to superconductor. Crucial to the physics on the
dual field theory is the fact that when embedded in string theory, black holes
in the bulk may become vulnerable to instability caused by brane
pair-production. Since dilaton arises naturally in the context of string
theory, we study the effect of coupling dilaton to Maxwell field on the
stability of flat charged AdS black holes. In particular, we study the
stability of Gao-Zhang black holes, which are locally asymptotically anti-de
Sitter. We find that for dilaton coupling parameter > 1, flat black
holes are stable against brane pair production, however for 0 < < 1,
the black holes eventually become unstable as the amount of electrical charges
is increased. Such instability however, behaves somewhat differently from that
of flat Reissner-Nordstr\"om black holes. In addition, we prove that the
Seiberg-Witten action of charged dilaton AdS black hole of Gao-Zhang type with
flat event horizon (at least in 5-dimension) is always logarithmically
divergent at infinity for finite values of , and is finite and positive
in the case tends to infinity . We also comment on the robustness of
our result for other charged dilaton black holes that are not of Gao-Zhang
type.Comment: Fixed some confusions regarding whether part of the discussions
concern electrically charged hole or magnetically charged one. No changes to
the result
Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve beneficial metabolic effects later in life even after the resumption of ad libitum (AL) feeding. We examined a range of metabolic parameters (body mass, body composition (lean and fat mass), glucose tolerance, fed blood glucose, fasting plasma insulin and insulin-like growth factor 1 (IGF-1), insulin sensitivity) in male C57BL/6 mice dietary switched from DR to AL (DR-AL) at 11 months of age (mid life). The converse switch (AL-DR) was also undertaken at this time. We then compared metabolic parameters of the switched mice to one another and to age-matched mice maintained exclusively on an AL or DR diet from early life (3 months of age) at 1 month, 6 months or 10 months post switch.</p>
<p>Results: Male mice dietary switched from AL-DR in mid life adopted the metabolic phenotype of mice exposed to DR from early life, so by the 10-month timepoint the AL-DR mice overlapped significantly with the DR mice in terms of their metabolic phenotype. Those animals switched from DR-AL in mid life showed clear evidence of a glycemic memory, with significantly improved glucose tolerance relative to mice maintained exclusively on AL feeding from early life. This difference in glucose tolerance was still apparent 10 months after the dietary switch, despite body mass, fasting insulin levels and insulin sensitivity all being similar to AL mice at this time.</p>
<p>Conclusions: Male C57BL/6 mice retain a long-term glycemic memory of early-life DR, in that glucose tolerance is enhanced in mice switched from DR-AL in mid life, relative to AL mice, even 10 months following the dietary switch. These data therefore indicate that the phenotypic benefits of DR are not completely dissipated following a return to AL feeding. The challenge now is to understand the molecular mechanisms underlying these effects, the time course of these effects and whether similar interventions can confer comparable benefits in humans.</p>
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