3,894 research outputs found
Precise Experimental Investigation of Eigenmodes in a Planar Ion Crystal
The accurate characterization of eigenmodes and eigenfrequencies of
two-dimensional ion crystals provides the foundation for the use of such
structures for quantum simulation purposes. We present a combined experimental
and theoretical study of two-dimensional ion crystals. We demonstrate that
standard pseudopotential theory accurately predicts the positions of the ions
and the location of structural transitions between different crystal
configurations. However, pseudopotential theory is insufficient to determine
eigenfrequencies of the two-dimensional ion crystals accurately but shows
significant deviations from the experimental data obtained from resolved
sideband spectroscopy. Agreement at the level of 2.5 x 10^(-3) is found with
the full time-dependent Coulomb theory using the Floquet-Lyapunov approach and
the effect is understood from the dynamics of two-dimensional ion crystals in
the Paul trap. The results represent initial steps towards an exploitation of
these structures for quantum simulation schemes.Comment: 5 pages, 4 figures, supplemental material (mathematica and matlab
files) available upon reques
Hydrogen-atom Attack on Phenol and Toluene is \u3cem\u3eortho\u3c/em\u3e-directed
The reaction of H + phenol and H/D + toluene has been studied in a supersonic expansion after electric discharge. The (1 + 1′) resonance-enhanced multiphoton ionization (REMPI) spectra of the reaction products, at m/z = parent + 1, or parent + 2 amu, were measured by scanning the first (resonance) laser. The resulting spectra are highly structured. Ionization energies were measured by scanning the second (ionization) laser, while the first laser was tuned to a specific transition. Theoretical calculations, benchmarked to the well-studied H + benzene → cyclohexadienyl radical reaction, were performed. The spectrum arising from the reaction of H + phenol is attributed solely to the ortho-hydroxy-cyclohexadienyl radical, which was found in two conformers (syn and anti). Similarly, the reaction of H/D + toluene formed solely the ortho isomer. The preference for the ortho isomer at 100–200 K in the molecular beam is attributed to kinetic, not thermodynamic effects, caused by an entrance channel barrier that is ∼5 kJ mol−1 lower for ortho than for other isomers. Based on these results, we predict that the reaction of H + phenol and H + toluene should still favour the ortho isomer under elevated temperature conditions in the early stages of combustion (200–400 °C)
Scaling Behavior of Cyclical Surface Growth
The scaling behavior of cyclical surface growth (e.g. deposition/desorption),
with the number of cycles n, is investigated. The roughness of surfaces grown
by two linear primary processes follows a scaling behavior with asymptotic
exponents inherited from the dominant process while the effective amplitudes
are determined by both. Relevant non-linear effects in the primary processes
may remain so or be rendered irrelevant. Numerical simulations for several
pairs of generic primary processes confirm these conclusions. Experimental
results for the surface roughness during cyclical electrodeposition/dissolution
of silver show a power-law dependence on n, consistent with the scaling
description.Comment: 2 figures adde
Multiscale Random-Walk Algorithm for Simulating Interfacial Pattern Formation
We present a novel computational method to simulate accurately a wide range
of interfacial patterns whose growth is limited by a large scale diffusion
field. To illustrate the computational power of this method, we demonstrate
that it can be used to simulate three-dimensional dendritic growth in a
previously unreachable range of low undercoolings that is of direct
experimental relevance.Comment: 4 pages RevTex, 6 eps figures; substantial changes in presentation,
but results and conclusions remain the sam
The critical window for the classical Ramsey-Tur\'an problem
The first application of Szemer\'edi's powerful regularity method was the
following celebrated Ramsey-Tur\'an result proved by Szemer\'edi in 1972: any
K_4-free graph on N vertices with independence number o(N) has at most (1/8 +
o(1)) N^2 edges. Four years later, Bollob\'as and Erd\H{o}s gave a surprising
geometric construction, utilizing the isoperimetric inequality for the high
dimensional sphere, of a K_4-free graph on N vertices with independence number
o(N) and (1/8 - o(1)) N^2 edges. Starting with Bollob\'as and Erd\H{o}s in
1976, several problems have been asked on estimating the minimum possible
independence number in the critical window, when the number of edges is about
N^2 / 8. These problems have received considerable attention and remained one
of the main open problems in this area. In this paper, we give nearly
best-possible bounds, solving the various open problems concerning this
critical window.Comment: 34 page
BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity
Interferon (IFN) induction of IFN-stimulated genes (ISGs) creates a formidable protective antiviral state. However, loss of appropriate control mechanisms can result in constitutive pathogenic ISG upregulation. Here, we used genome-scale loss-of-function screening to establish genes critical for IFN-induced transcription, identifying all expected members of the JAK-STAT signaling pathway and a previously unappreciated epigenetic reader, bromodomain-containing protein 9 (BRD9), the defining subunit of non-canonical BAF (ncBAF) chromatin-remodeling complexes. Genetic knockout or small-molecule-mediated degradation of BRD9 limits IFN-induced expression of a subset of ISGs in multiple cell types and prevents IFN from exerting full antiviral activity against several RNA and DNA viruses, including influenza virus, human immunodeficiency virus (HIV1), and herpes simplex virus (HSV1). Mechanistically, BRD9 acts at the level of transcription, and its IFN-triggered proximal association with the ISG transcriptional activator, STAT2, suggests a functional localization at selected ISG promoters. Furthermore, BRD9 relies on its intact acetyl-binding bromodomain and unique ncBAF scaffolding interaction with GLTSCR1/1L to promote IFN action. Given its druggability, BRD9 is an attractive target for dampening ISG expression under certain autoinflammatory conditions
Roughness Scaling in Cyclical Surface Growth
The scaling behavior of cyclical growth (e.g. cycles of alternating
deposition and desorption primary processes) is investigated theoretically and
probed experimentally. The scaling approach to kinetic roughening is
generalized to cyclical processes by substituting the time by the number of
cycles . The roughness is predicted to grow as where is
the cyclical growth exponent. The roughness saturates to a value which scales
with the system size as , where is the cyclical
roughness exponent. The relations between the cyclical exponents and the
corresponding exponents of the primary processes are studied. Exact relations
are found for cycles composed of primary linear processes. An approximate
renormalization group approach is introduced to analyze non-linear effects in
the primary processes. The analytical results are backed by extensive numerical
simulations of different pairs of primary processes, both linear and
non-linear. Experimentally, silver surfaces are grown by a cyclical process
composed of electrodeposition followed by 50% electrodissolution. The roughness
is found to increase as a power-law of , consistent with the scaling
behavior anticipated theoretically. Potential applications of cyclical scaling
include accelerated testing of rechargeable batteries, and improved
chemotherapeutic treatment of cancerous tumors
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