Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake

© The Royal Society of Chemistry 2015. Selenoproteins play important roles in antioxidant mechanisms, and are thus hypothesised to have some involvement in the pathology of certain types of dementia. Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are both thought to involve impaired biological activity of certain selenoproteins. Previously, supplementation with a selenium-rich Brazil nut (Bertholletia excelsa) has shown potential in reducing cognitive decline in MCI patients, and could prove to be a safe and effective nutritional approach early in the disease process to slow decline. Here, we have conducted a pilot study that examined the effects of a range of single nucleotide polymorphisms (SNPs) in genes encoding the selenoproteins glutathione peroxidase (GPX1) and selenoprotein P (SEPP) in response to selenium supplementation via dietary Brazil nuts, including selenium status, oxidative stress parameters and GPX1 and SEPP gene expression. Our data suggest that GPX1 Pro198Leu rs1050450 genotypes may differentially affect the selenium status and GPx activity. Moreover, rs7579 and rs3877899 SNPs in SEPP gene, as well as GPX1 rs1050450 genotypes can influence the expression of GPX1 and SEPP mRNA in response to Brazil nuts intake. This small study gives cause for larger investigations into the role of these SNPs in both the selenium status and response to selenium dietary intake, especially in chronic degenerative conditions like MCI and AD

Serotonin receptor inhibitor is associated with falls independent of frailty in older adults

Objectives: To evaluate whether fall risk in older adults is associated with the use of selective serotonin receptor inhibitor (SSRI) monotherapy among geriatric outpatients, and whether this association is moderated by the presence of depressive disorder and/or frailty. Methods: Prospective cohort study with a 12-month follow-up and including 811 community-dwelling adults aged 60 or older from a university-based Geriatric Outpatient Unit. Major depressive disorder (MDD) was diagnosed according to DSM-5 criteria; subsyndromal depression as not meeting MDD criteria, but a Geriatric Depression Scale 15-item score ? 6 points. Frailty was evaluated with the FRAIL questionnaire. The association between SSRI use, depression, or both as well as the association between SSRI use, frailty, or both with falls were estimated through a generalized estimating equation (GEE) adjusted for relevant confounders. Results: At baseline, 297 patients (36.6%) used a SSRI (82 without remitted depression) and 306 (37.7%) were classified as physically frail. Frailty was more prevalent among SSRI users (44.8% versus 33.7%, p =.004). After 12 months, 179 participants had at least one fall (22.1%). SSRI use, depression as well as frailty were all independently associated with falls during follow-up. Nonetheless, patients with concurrent of SSRI usage and non-remitted depression had no higher risk compared to either remitted SSRI users or depressed patients without SSRIs. In contrast, concurrence of SSRI use and frailty increases the risk of falling substantially above those by SSRI usage or frailty alone. Conclusion: SSRI usage was independently associated with falls. Especially in frail-depressed patients, treatment strategies for depression other than SSRIs should be considered

STUDY ON THE DISPOSAL OF WASTE FROM THE HYDROGEN GENERATION BY ALUMINUM OXIDATION IN ALKALINE SOLUTION

In face of the current high energy consumption and demand worldwide, a change to a sustainable energy matrix became one of the pillars for global sustainability. The use of renewable energy has been one of the most attractive subjects in recent years. Several public policies in this matter have been suggested and there are ongoing efforts toward their implementation. The United Nations (UN) proposed what is called the 2030 Agenda, which considers 17 Sustainable Development Goals (SDG) to be achieved by the year 2030. In support of the 2030 Agenda, research on the production of fuels from clean and sustainable sources is being conducted by the scientific community around the world. Fossil fuels are finite and also a major source of environmental pollutants, therefore the choice of using renewable sources of energy tends to be an increasingly growing and attractive alternative. Hydrogen is a fuel with a high heating value and is known as the most abundant gaseous element and simplest in chemical structure. The scientific community researching fuel cells has given much attention to the generation and storage of hydrogen. Besides the electrolytic hydrogen production and the reforming of fossil fuels (e.g., natural gas), hydrogen can be generated by metallic means, for example, by oxidation of aluminum in an alkaline solution. The use of recyclable metals, such as aluminum in this study, is an option for sustainable hydrogen generation processes. Nevertheless, like any chemical reaction, part of the products generated are waste, and some are even harmful to the environment, which makes the production of sustainable fuels unfeasible in case of not finding an appropriate technological industrial destination for such waste. The herein study comprises the investigation of the industrial and technological applications of the products of the hydrogen generation reaction from aluminum. Mastering the chemical reaction parameters of that reaction is paramount for the optimal design of a hydrogen generation system. The disposal of the waste is relevant since it makes the energy supply chain complete and sustainable