Stable Non-Supersymmetric Supergravity Solutions from Deformations of the Maldacena-Nunez Background

We study a deformation of the type IIB Maldacena-Nunez background which arises as the near-horizon limit of NS5 branes wrapped on a two-cycle. This background is dual to a "little string theory" compactified on a two-sphere, a theory which at low energies includes four-dimensional N = 1 super Yang-Mills theory. The deformation we study corresponds to a mass term for some of the scalar fields in this theory, and it breaks supersymmetry completely. In the language of seven-dimensional SO(4) gauged supergravity the deformation involves (at leading order) giving a VEV, depending only on the radial coordinate, to a particular scalar field. We explicitly construct the corresponding solution at leading order in the deformation, both in seven-dimensional and in ten-dimensional supergravity, and we verify that it completely breaks supersymmetry. Since the original background had a mass gap and we are performing a small deformation, the deformed background is guaranteed to be stable even though it is not supersymmetric.Comment: 1+31 pages, one figure. v2: minor clarifications, refs adde

Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes

Insulin action initiates a series of phosphorylation events regulating cellular differentiation, growth and metabolism. We have previously discovered, in a mass spectrometry-based phosphoproteomic study, that insulin/IGF-1 signalling induces phosphorylation of retinoid x receptor alpha (RXRα) at S22 in mouse brown pre-adipocytes. Here, we show that insulin induces the phosphorylation of RXRα at S22 in both brown precursor and mature adipocytes through a pathway involving ERK, downstream of IRS-1 and −2. We also found that RXRα S22 phosphorylation is promoted by insulin and upon re-feeding in brown adipose tissue in vivo, and that insulin-stimulated S22 phosphorylation of RXRα is dampened by diet-induced obesity. We used Rxra knockout cells re-expressing wild type (WT) or S22A non-phosphorylatable forms of RXRα to further characterize the role of S22 in brown adipocytes. Knockout of Rxra in brown pre-adipocytes resulted in decreased lipid accumulation and adipogenic gene expression during differentiation, and re-expression of RxraWT alleviated these effects. However, we observed no significant difference in cells re-expressing the RxraS22A mutant as compared with the cells re-expressing RxraWT. Furthermore, comparison of gene expression during adipogenesis in the WT and S22A re-expressing cells by RNA sequencing revealed similar transcriptomic profiles. Thus, our data propose a dispensable role for RXRα S22 phosphorylation in adipogenesis and transcription in differentiating brown pre-adipocytes

Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes

Insulin action initiates a series of phosphorylation events regulating cellular differentiation, growth and metabolism. We have previously discovered, in a mass spectrometry-based phosphoproteomic study, that insulin/IGF-1 signalling induces phosphorylation of retinoid x receptor alpha (RXRα) at S22 in mouse brown pre-adipocytes. Here, we show that insulin induces the phosphorylation of RXRα at S22 in both brown precursor and mature adipocytes through a pathway involving ERK, downstream of IRS-1 and −2. We also found that RXRα S22 phosphorylation is promoted by insulin and upon re-feeding in brown adipose tissue in vivo, and that insulin-stimulated S22 phosphorylation of RXRα is dampened by diet-induced obesity. We used Rxra knockout cells re-expressing wild type (WT) or S22A non-phosphorylatable forms of RXRα to further characterize the role of S22 in brown adipocytes. Knockout of Rxra in brown pre-adipocytes resulted in decreased lipid accumulation and adipogenic gene expression during differentiation, and re-expression of RxraWT alleviated these effects. However, we observed no significant difference in cells re-expressing the RxraS22A mutant as compared with the cells re-expressing RxraWT. Furthermore, comparison of gene expression during adipogenesis in the WT and S22A re-expressing cells by RNA sequencing revealed similar transcriptomic profiles. Thus, our data propose a dispensable role for RXRα S22 phosphorylation in adipogenesis and transcription in differentiating brown pre-adipocytes

On Penrose Limits and Gauge Theories

We discuss various Penrose limits of conformal and nonconformal backgrounds. In AdS_5 x T^{1,1}, for a particular choice of the angular coordinate in T^{1,1} the resulting Penrose limit coincides with the similar limit for AdS_5 x S^5. In this case an identification of a subset of field theory operators with the string zero modes creation operators is possible. For another limit we obtain a light-cone string action that resembles a particle in a magnetic field. We also consider three different types of backgrounds that are dual to nonconformal field theories: The Schwarzschild black hole in AdS_5, D3-branes on the small resolution of the conifold and the Klebanov-Tseytlin background. We find that in all three cases the introduction of nonconformality renders a theory that is no longer exactly solvable and that the form of the deformation is universal. The corresponding world sheet theory in the light-cone gauge has a \tau=x^+ dependent mass term.Comment: 17pp, late

Self-organization in a phonon laser

We make an adaptation of laser modelling equations to describe the behavior of a phonon laser (saser). Our saser consists of an AlGaAs/GaAs double barrier heterostructure designed to generate an intense beam of transversal acoustic (TA) phonons. To study our system, we begin with a Hamiltonian that describes the decay of primary longitudinal optical phonons (LO_1) into secondary (LO_2) and TA (LO_1 -> LO_2 + TA) and its inverse process (recombination). Using this Hamiltonian, a set of coupled equations of motion for the phonons is obtained. We also consider the interaction between the phonons and its reservoirs. These interactions are introduced in the equations of motion leading to a set of coupled Langevin equations. In order to obtain an expression to describe our saser we apply, in the Langevin equations, an adiabatic elimination of some variables of the subsystem. Following the method above we obtain the value of the injection threshold for the operation of our phonon laser. At this threshold occurs a phase transition from a disordered to a coherent state. It is shown that it is not necessary a big "optical" pumping to get a sasing region.Comment: 4 figure

MACS J0553.4-3342: a young merging galaxy cluster caught through the eyes of Chandra and HST

FWN – Publicaties zonder aanstelling Universiteit Leide

Possible origins of macroscopic left-right asymmetry in organisms

I consider the microscopic mechanisms by which a particular left-right (L/R) asymmetry is generated at the organism level from the microscopic handedness of cytoskeletal molecules. In light of a fundamental symmetry principle, the typical pattern-formation mechanisms of diffusion plus regulation cannot implement the "right-hand rule"; at the microscopic level, the cell's cytoskeleton of chiral filaments seems always to be involved, usually in collective states driven by polymerization forces or molecular motors. It seems particularly easy for handedness to emerge in a shear or rotation in the background of an effectively two-dimensional system, such as the cell membrane or a layer of cells, as this requires no pre-existing axis apart from the layer normal. I detail a scenario involving actin/myosin layers in snails and in C. elegans, and also one about the microtubule layer in plant cells. I also survey the other examples that I am aware of, such as the emergence of handedness such as the emergence of handedness in neurons, in eukaryote cell motility, and in non-flagellated bacteria.Comment: 42 pages, 6 figures, resubmitted to J. Stat. Phys. special issue. Major rewrite, rearranged sections/subsections, new Fig 3 + 6, new physics in Sec 2.4 and 3.4.1, added Sec 5 and subsections of Sec

Evidence for a narrow dip structure at 1.9 GeV/c2^2 in 3π+3π−3\pi^+ 3\pi^- diffractive photoproduction

A narrow dip structure has been observed at 1.9 GeV/c$^2$ in a study of diffractive photoproduction of the $~3\pi^+3\pi^-$ final state performed by the Fermilab experiment E687.Comment: The data of Figure 6 can be obtained by downloading the raw data file e687_6pi.txt. v5 (2nov2018): added Fig. 7, the 6 pion energy distribution as requested by a reade

Citizenship status and career self-efficacy: An intersectional study of biomedical trainees in the United States

This study examines the intersectional role of citizenship and gender with career self-efficacy amongst 10,803 doctoral and postdoctoral trainees in US universities. These biomedical trainees completed surveys administered by 17 US institutions that participated in the National Institutes of Health Broadening Experiences in Scientific Training (NIH BEST) Programs. Findings indicate that career self-efficacy of non-citizen trainees is significantly lower than that of US citizen trainees. While lower career efficacy was observed in women compared with men, it was even lower for non-citizen female trainees. Results suggest that specific career interests may be related to career self-efficacy. Relative to US citizen trainees, both male and female non-citizen trainees showed higher interest in pursuing a career as an academic research investigator. In comparison with non-citizen female trainees and citizen trainees of all genders, non-citizen male trainees expressed the highest interest in research-intensive (and especially principal investigator) careers. The authors discuss potential causes for these results and offer recommendations for increasing trainee career self-efficacy which can be incorporated into graduate and postdoctoral training

Career self-efficacy disparities in underrepresented biomedical scientist trainees

The present study examines racial, ethnic, and gender disparities in career self-efficacy amongst 6077 US citizens and US naturalized graduate and postdoctoral trainees. Respondents from biomedical fields completed surveys administered by the National Institutes of Health Broadening Experiences in Scientific Training (NIH BEST) programs across 17 US institutional sites. Graduate and postdoctoral demographic and survey response data were examined to evaluate the impact of intersectional identities on trainee career self-efficacy. The study hypothesized that race, ethnicity and gender, and the relations between these identities, would impact trainee career self-efficacy. The analysis demonstrated that racial and ethnic group, gender, specific career interests (academic principal investigator vs. other careers), and seniority (junior vs. senior trainee level) were, to various degrees, all associated with trainee career self-efficacy and the effects were consistent across graduate and postdoctoral respondents. Implications for differing levels of self-efficacy are discussed, including factors and events during training that may contribute to (or undermine) career self-efficacy. The importance of mentorship for building research and career self-efficacy of trainees is discussed, especially with respect to those identifying as women and belonging to racial/ethnic populations underrepresented in biomedical sciences. The results underscore the need for change in the biomedical academic research community in order to retain a diverse biomedical workforce