Spin-Forbidden Excitation Enables Infrared Photoredox Catalysis

We describe a new family of catalysts that undergo direct ground state singlet to excited state triplet excitation with IR light, leading to photoredox catalysis without the energy waste associated with intersystem crossing. The finding allows a mole scale reaction in batch using infrared irradiation

Zinc Acetate-Promoted Buchwald–Hartwig Couplings of Heteroaromatic Amines

Zinc salts have been shown to promote the Buchwald–Hartwig coupling of azaindoles and azaindazoles with heteroaryl chlorides to provide the corresponding 1-aryl-1<i>H</i>-azaindoles and 1-aryl-1<i>H</i>-azaindazoles. The substrate scope and mechanistic aspects of this reaction were explored

Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation

Zinc Acetate-Promoted Buchwald–Hartwig Couplings of Heteroaromatic Amines

Zinc salts have been shown to promote the Buchwald–Hartwig coupling of azaindoles and azaindazoles with heteroaryl chlorides to provide the corresponding 1-aryl-1<i>H</i>-azaindoles and 1-aryl-1<i>H</i>-azaindazoles. The substrate scope and mechanistic aspects of this reaction were explored

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound <b>1A</b> with complete stereocontrol, is reported