Some clinical aspects of diabetes with relation to insulin and tolbutamide

No Abstrac

Cancer and ectopic hormones

Tumours of non-endocrine organs may cause endocrine syndromes through the production of 'ectopic' hormones. Ectopic corticotrophin was probably responsible for the first published cases, and the clinical condition related to this hormone is described. It can be mimicked by ectopically-produced corticotrophin-releasing hormone. Tumorous hypercalcaemia is usually caused by an ectopic parathyroid hormone-like substance, while inappropriate antidiuresis may be due to an ectopic antidiuretic hormone. Hyperthyroidism can be induced by a thyroid-stimulating hormone derived from trophoblastic tumours, which probably differs from normal placental TSH. The possible mechanisms underlying these phenomena are 'de-repression' (most likely) and total breakdown of the genetic code in the tumour cells.S. Afr. Med. J., 48, 347 (1974)

Oral sulphonylureas in the management of diabetes

No Abstract

Diabetic embryopathy

No Abstract

Intersexual causes of primary amenorrhoea

No Abstract

Hyperglycaemic non-ketotic coma following surgically treated acromegaly in a non-diabetic

Extremely severe, hyperglybemic, hyperosmolar, nonketotic coma occurred in a   47-year-old, apparently nondiabetic, acromegalic woman shortly after having her pituitary adenoma removed. She was totally unconscious, shocked, anuric, grossly  dehydrated and in status pilepticus but she recovered, and has remained non-diabetic, with diminished adrenal response and growth hormone levels returning to normal. Her plasma insulin response to glucose is excellent. The factors that precipitated this  syndrome in this patient are obscure to us

Clinical trial of amino-methylbenzol-sulphonyl-cyclohexylurea (Metahexamide) in diabetics after failure of tolbutamide

No Abstract

Complete remission of diabetes mellitus during pregnancy

No Abstract

Studies in Rickets in the Cape Peninsula

No Abstrac

Preliminary trial of a powerful new sulphonylurea in maturity-onset diabetes-HB419 (Glibenclamide)

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