Additional file 2: Table S1. of Modeling the energetic cost of cancer as a result of altered energy metabolism: implications for cachexia

Percent of increased measured tumor energy expenditure, P cost  = P Cori   + P aerobic , due to different metabolic pathways, according to our model, at various percentages of ATP supplied by glycolysis, X anaerobic . (PDF 58 kb

Additional file 2: Figure S5. of A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models

Non-reactive PAC profiles across the lobule without diffusion in 3D – block view. (a) PAC at 0.01 min, (b) PAC at 0.05 min, (c) PAC at 0.1 min (d) PAC at 1 min. Color bar is in molfrac. (PPTX 613 kb

Additional file 5: of Modeling the energetic cost of cancer as a result of altered energy metabolism: implications for cachexia

Recurrence relation g(p cancer , p anaerobic ). Additional explanation is given to the recurrence relation g(p cancer , p anaerobic ) and how it is used to calculate p lost . (PDF 70 kb

Additional file 1: Figure S1. of A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models

Non-reactive PAC profiles across the lobule with diffusion. (a) PAC at 0.01 min, (b) PAC at 0.1 min, (c) PAC at 0.2 min (d) PAC at 0.5 min. Color bar is in molfrac. (PPTX 206 kb

Additional file 6: Figure S4. of A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models

Reactive (6 × 10-3 min-1) PAC and PAC-OH profiles across the lobule with diffusion effects and base case metabolism in 3D – sliced view. (a) PAC at 0.1 min, (b) PAC at 0.5 min, (c) PAC at 1 min, (d) PAC-OH at 0.1 min, (e) PAC-OH at 0.5 min, (f) PAC-OH at 1 min. Color bar is in molfrac. (PPTX 378 kb

Additional file 3: of Modeling the energetic cost of cancer as a result of altered energy metabolism: implications for cachexia

Tumor cost from oxygen consumption increase. Additional details of the calculation of tumor cost from oxygen consumption increase in Study B are given. (PDF 72 kb

Additional file 1: Table S1. of A strategy to identify housekeeping genes suitable for analysis in breast cancer diseases

Primer sequences for gene expression measure by qRT-PCR. (DOC 44 kb

Non-reactive PAC drug propagation across the hepatic root.

<p>Non-reactive PAC drug propagation across the hepatic root.</p

Color bar representing concentration of drug (or metabolite).

<p>Color bar representing concentration of drug (or metabolite).</p

Injected flow (PAC) steady-state flow across the liver structure with short-time flow transient.

<p>Injected flow (PAC) steady-state flow across the liver structure with short-time flow transient.</p